[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100610668":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":29,"locations":18,"responsibleParty":40,"collaborators":42,"id":53,"slug":18,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":18,"eligibilityCriteria":58,"healthyVolunteers":54,"sex":59,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":18,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":73,"overallStatus":78,"whyStopped":18,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":18},{"fullName":5,"class":6},"The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"NK cell perfusion group","EXPERIMENTAL","Accepting NK cell therapy",[13],"Biological: NK cell perfusion group",{"label":15,"type":16,"description":17,"interventionNames":18},"Control group","NO_INTERVENTION","Not accepting NK cell therapy",null,[20],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":18},"BIOLOGICAL","Completing two rounds of NK cell therapy",[9],[25],{"name":26,"affiliation":27,"role":28},"Yali Hu","The Affiliated Drum Tower Hospital of Nanjing University","PRINCIPAL_INVESTIGATOR",[30,35],{"name":26,"role":31,"phone":32,"phoneExt":33,"email":34},"CONTACT","86-025-83106666","11201","glyyhuyali@163.com",{"name":36,"role":31,"phone":37,"phoneExt":38,"email":39},"Hui Zhu","86-025-8310666","54330","zhuhui1231@126.com",{"type":28,"investigatorFullName":26,"investigatorTitle":41,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"M.D., Ph.D.",[43,45,47,49,51],{"name":44,"class":6},"The University of Science and Technology of China",{"name":46,"class":6},"Sir Run Run Shaw Hospital",{"name":48,"class":6},"Second Affiliated Hospital of Soochow University",{"name":50,"class":6},"The First Affiliated Hospital of Anhui Medical University",{"name":52,"class":6},"The First Affiliated Hospital of University of Science and Technology of China","100610668",false,"NCT07230574","Autologous Decidual-like Natural Killer Cells Therapy for Reproductive Failure","A Prospective, Multicenter, Randomized Controlled Clinical Study on Autologous Decidual-like NK Cells Therapy for Reproductive Failure Associated With Abnormal Uterine Natural Killer Cells","Inclusion Criteria:\n\n* Reproductive failure with abnormal endometrial natural killer (NK) cells in menstrual blood;\n* With a clear intention to conceive;\n* Normal ovarian function, or premature ovarian insufficiency with ≥2 high-quality cryopreserved embryos available for transfer;\n* Endometrial thickness measured by transvaginal ultrasound during the periovulatory period ≥7 mm;\n* Body mass index (BMI) between 18 kg\u002Fm² and 28 kg\u002Fm²;\n* Willing to comply with the follow-up plan of this study.\n\nExclusion Criteria:\n\n* Use of progesterone receptor modulators;\n* One of the couple's chromosomal karyotype abnormalities, with no euploid embryo identified via preimplantation genetic testing for aneuploidy;\n* Severe endometriosis or adenomyosis, uterine fibroids affecting uterine cavity morphology, uterine malformations, intrauterine adhesions, or thin endometrium;\n* Uncontrolled autoimmune or endocrine disorders;\n* Contraindications to pregnancy;\n* History of malignant tumors;\n* Participating in other clinical studies;\n* Allergy to blood products.","FEMALE","22 Years","38 Years",{"count":63,"type":64},159,"ESTIMATED","INTERVENTIONAL",[67],"PHASE2","The aim of this study is to verify the efficacy of in vitro induction of autologous decidual-like NK cells therapy for reproductive failure associated with uterine NK cells abnormalities.",[70,71,72],"Abortion, Missed","Infertility Unexplained","Reproductive Disorder",[74,75,76,77],"Recurrent Pregnancy Loss","Repeated Implantation Failure","Unexplained Infertility","Decidual Natural Killer Cells","NOT_YET_RECRUITING","2025-11-13",{"date":81,"type":82},"2025-11-17","ACTUAL",{"date":84,"type":64},"2025-11",{"date":86,"type":64},"2028-09",{"name":5,"class":6}]