[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100564430":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":32,"centralContacts":37,"locations":43,"responsibleParty":63,"collaborators":65,"id":69,"slug":22,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":22,"eligibilityCriteria":74,"healthyVolunteers":75,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":22,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":89,"overallStatus":46,"whyStopped":22,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"University of Wisconsin, Madison","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Middle-Aged Adults","EXPERIMENTAL","Middle-Aged Adults between 55-69 years of age.",[13,14,15],"Device: MRI","Drug: Prazosin","Drug: Placebo",[17,23,28],{"type":18,"name":19,"description":20,"armGroupLabels":21,"otherNames":22},"DEVICE","MRI","Participants will undergo an MRI scan while performing breathing and a simulated postural change task.",[9],null,{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":22},"DRUG","Prazosin","A dose of prazosin will be administered based on body weight.",[9],{"type":24,"name":29,"description":30,"armGroupLabels":31,"otherNames":22},"Placebo","Oral placebo",[9],[33],{"name":34,"affiliation":35,"role":36},"Jill Barnes, PhD","UW Madison","PRINCIPAL_INVESTIGATOR",[38],{"name":39,"role":40,"phone":41,"phoneExt":22,"email":42},"Anna Howery","CONTACT","608-262-9572","ahowery@wisc.edu",[44],{"facility":45,"status":46,"city":47,"state":48,"zip":49,"country":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"University of Wisconsin","RECRUITING","Madison","Wisconsin","53705","United States",{"type":52,"coordinates":53},"Point",[54,55],-89.40123,43.07305,{"lat":55,"lon":54},[58,61],{"name":59,"role":40,"phone":41,"phoneExt":22,"email":60},"Anna J Howery, MS","barneslab@education.wisc.edu",{"name":62,"role":36,"phone":22,"phoneExt":22,"email":22},"Jill N Barnes, PhD",{"type":64,"investigatorFullName":22,"investigatorTitle":22,"investigatorAffiliation":22,"oldNameTitle":22,"oldOrganization":22},"SPONSOR",[66],{"name":67,"class":68},"National Institute of Neurological Disorders and Stroke (NINDS)","NIH","100564430",false,"NCT06629077","Brain Blood Vessel Responses to Changes in Blood Flow","Cerebrovascular Responses to Acute Hypoperfusion","Inclusion Criteria:\n\n* Between the ages of 55-69 years\n* Have a BMI less than or equal to 34.5 kg\u002Fm2\n* Nonsmoker\n* are less than 72 in (182.88 cm) height\n* Females must be postmenopausal\n\nExclusion Criteria:\n\n* Diagnosis of Mild Cognitive Impairment (MCI) or Alzheimer's disease (AD)\n* History or evidence of hepatic disease, hematological disease, or peripheral vascular disease; severe kidney injury requiring hemodialysis\n* History of cardiovascular disease including: severe congestive heart failure, coronary artery disease, ischemic heart disease (stents, coronary artery bypass grafts) and tachycardia\n* Uncontrolled hypertension\n* History of clinically significant ischemic or hemorrhagic stroke, or significant cerebrovascular disease\n* Severe untreated obstructive sleep apnea\n* History of diabetes with HbA1c greater than 9.5%\n* Major neurologic disorders other than dementia (e.g., MS, ALS, brain surgery, etc.)\n* Current or recent (\\<1 year) major psychiatric condition (Axis I) or addictive disorders\n* Significant surgical history\n* Other significant medical conditions at investigators' discretion\n* Contraindications to MRI\n* Prescribed medications that interfere with prazosin\n* Lactose allergy\n* lower body will not fit in lower body negative pressure (LBNP) chamber (regardless of overall height and BMI).",true,"ALL","55 Years","69 Years",{"count":80,"type":81},36,"ESTIMATED","INTERVENTIONAL",[84],"PHASE2","Brain blood flow will be measured during a simulated postural change test and while breathing increased levels of carbon dioxide using magnetic resonance imaging.",[87,88],"Magnetic Resonance Imaging","Cerebrovascular Circulation",[87,90,91,92],"Brain Blood Flow","Lower Body Negative Pressure","Carbon Dioxide","2026-02-27",{"date":95,"type":96},"2026-03-02","ACTUAL",{"date":98,"type":96},"2026-02-26",{"date":100,"type":81},"2027-01",{"name":5,"class":6},1]