[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100564431":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":32,"centralContacts":37,"locations":43,"responsibleParty":63,"collaborators":22,"id":65,"slug":22,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":22,"eligibilityCriteria":70,"healthyVolunteers":71,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":22,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":85,"overallStatus":46,"whyStopped":22,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"University of Wisconsin, Madison","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Young Adults","EXPERIMENTAL","Young Adults between 20-40 years of age.",[13,14,15],"Device: MRI","Drug: Prazosin","Drug: Placebo",[17,23,28],{"type":18,"name":19,"description":20,"armGroupLabels":21,"otherNames":22},"DEVICE","MRI","Participants will undergo an MRI scan while performing breathing and simulated postural change tasks.",[9],null,{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":22},"DRUG","Prazosin","A dose of prazosin will be administered based on body weight",[9],{"type":24,"name":29,"description":30,"armGroupLabels":31,"otherNames":22},"Placebo","Oral placebo",[9],[33],{"name":34,"affiliation":35,"role":36},"Jill Barnes, PhD","UW Madison","PRINCIPAL_INVESTIGATOR",[38],{"name":39,"role":40,"phone":41,"phoneExt":22,"email":42},"Anna Howery","CONTACT","608-262-9572","ahowery@wisc.edu",[44],{"facility":45,"status":46,"city":47,"state":48,"zip":49,"country":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"University of Wisconsin","RECRUITING","Madison","Wisconsin","53705","United States",{"type":52,"coordinates":53},"Point",[54,55],-89.40123,43.07305,{"lat":55,"lon":54},[58,61],{"name":59,"role":40,"phone":41,"phoneExt":22,"email":60},"Anna J Howery, MS","barneslab@education.wisc.edu",{"name":62,"role":36,"phone":22,"phoneExt":22,"email":22},"Jill N Barnes, PhD",{"type":64,"investigatorFullName":22,"investigatorTitle":22,"investigatorAffiliation":22,"oldNameTitle":22,"oldOrganization":22},"SPONSOR","100564431",false,"NCT06629090","Brain Blood Vessel Responses to Changes in Blood Flow: Younger Cohort","Cerebrovascular Responses to Acute Hypoperfusion","Inclusion Criteria:\n\n* Between the ages of 20-40 years\n* Have a BMI ≤34.5 kg\u002Fm2\n* are less than 72 in (182.88 cm) height\n* Nonsmoker\n\nExclusion Criteria:\n\n* Diagnosis of Mild Cognitive Impairment (MCI) or Alzheimer's disease (AD)\n* History or evidence of hepatic disease, hematological disease, or peripheral vascular disease; severe kidney injury requiring hemodialysis\n* History of cardiovascular disease including: severe congestive heart failure, coronary artery disease, ischemic heart disease (stents, coronary artery bypass grafts) and tachycardia\n* Uncontrolled hypertension\n* History of clinically significant ischemic or hemorrhagic stroke, or significant cerebrovascular disease\n* Severe untreated obstructive sleep apnea\n* History of diabetes with HbA1c greater than 9.5 percent\n* Major neurologic disorders other than dementia (e.g., MS, ALS, brain surgery, etc.)\n* Current or recent (less than1 year) major psychiatric condition (Axis I) or addictive disorders\n* Significant surgical history\n* Other significant medical conditions at investigators' discretion\n* Contraindications to MRI\n* Prescribed medications that interfere with prazosin\n* Lactose allergy\n* lower body will not fit in lower body negative pressure (LBNP) chamber (regardless of overall height and BMI)",true,"ALL","20 Years","40 Years",{"count":76,"type":77},36,"ESTIMATED","INTERVENTIONAL",[80],"PHASE2","Brain blood flow will be measured during a simulated postural change test and while breathing increased levels of carbon dioxide using magnetic resonance imaging.",[83,84],"Magnetic Resonance Imaging","Cerebrovascular Circulation",[83,86,87,88],"Brain Blood Flow","Lower Body Negative Pressure","Carbon Dioxide","2025-12-17",{"date":91,"type":92},"2025-12-18","ACTUAL",{"date":89,"type":92},{"date":95,"type":77},"2026-12",{"name":5,"class":6},1]