[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100614449":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":31,"centralContacts":25,"locations":36,"responsibleParty":56,"collaborators":58,"id":64,"slug":25,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":65,"sex":71,"minAge":25,"maxAge":25,"enrollmentInfo":72,"targetDuration":25,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":86,"overallStatus":38,"whyStopped":25,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Sunnybrook Health Sciences Centre","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Methylphenidate + iTBS","EXPERIMENTAL","Participants are currently receiving methylphenidate and receive iTBS in this study.",[13,14],"Device: intermittent theta burst stimulation (iTBS)","Drug: Methylphenidate (MPH)",{"label":16,"type":10,"description":17,"interventionNames":18},"iTBS only","iTBS only, no medication for apathy",[13],[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","intermittent theta burst stimulation (iTBS)","iTBS is a form of repetitive transcranial magnetic simulation (rTMS), a non-invasive form of brain stimulation.",[9,16],null,{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":25},"DRUG","Methylphenidate (MPH)","Participants will be on methylphenidate clinically prior to the trial",[9],[32],{"name":33,"affiliation":34,"role":35},"Krista Lanctot, PhD","Sunnybrook Research Institute","PRINCIPAL_INVESTIGATOR",[37],{"facility":34,"status":38,"city":39,"state":40,"zip":41,"country":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"RECRUITING","Toronto","Ontario","M4N 3M5","Canada",{"type":44,"coordinates":45},"Point",[46,47],-79.39864,43.70643,{"lat":47,"lon":46},[50],{"name":51,"role":52,"phone":53,"phoneExt":54,"email":55},"Study Coordinator","CONTACT","416-480-6100","63185","memoryresearch@sunnybrook.ca",{"type":57,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[59,61,62],{"name":60,"class":6},"Alzheimer Society of Canada",{"name":34,"class":6},{"name":63,"class":6},"Brain Canada","100614449",false,"NCT07279740","Combined Brain Stimulation and Methylphenidate Treatment for Apathy in Dementia","Methylphenidate Primed iTBS for Apathy in Neurocognitive Disorders","PRIME","Inclusion Criteria:\n\n* Alzheimer's disease or mixed Alzheimer's disease and vascular disease\n* MMSE score 10-28 inclusive\n* Clinically significant apathy\n* Stable dose of psychotropic medication\n* Care partner must spend at least 10hrs\u002Fweek with the participant\n\nExclusion Criteria:\n\n* Major Depressive Episode\n* Clinically significant agitation, delusions, hallucinations\n* Currently talking a dopaminergic agent other than methylphenidate\n* Failure to clear the TMS adult safety scale (e.g. unapproved pacemakers, metallic implants, history of epilepsy)\n* Central nervous system abnormalities (other than Alzheimer's disease) deemed clinically significant by study physician or seizures\n* Any condition that in the opinion of the study physician, makes it medically unsafe for the patient to enroll in the trial","ALL",{"count":73,"type":74},12,"ESTIMATED","INTERVENTIONAL",[77],"PHASE2","This study evaluates whether the combined treatment of methylphenidate and non-invasive brain stimulation, called intermittent theta burst stimulation, can effectively treat apathy in individuals with Alzheimer's disease or mixed AD\u002Fvascular dementia",[80,81,82,83,84,85],"Alzheimer s Disease","Alzheimer Dementia (AD)","Alzheimer Dementia","Alzheimer Disease","Apathy","Apathy in Dementia",[87,88,89,90,91,92,93,94],"apathy","dementia","Alzheimer's disease","methylphenidate","rTMS","iTBS","repetitive transcranial magnetic stimulation","intermittent theta burst stimulation","2025-12-11",{"date":97,"type":98},"2025-12-12","ACTUAL",{"date":100,"type":74},"2026-01",{"date":102,"type":74},"2027-10-01",{"name":5,"class":6},1]