Gout is a systemic disease that results from the deposition of monosodium urate crystals (MSU) in tissues. Increased serum uric acid (SUA) above a specific threshold (\>6.8 mg/dl) is a requirement for the formation of uric acid crystals. MSU crystals can be deposited in all tissues mainly in and around the joints forming tophi. Early presentation of gout is an acute joint inflammation that is quickly relieved by non-steroidal anti-inflammatory drugs (NSAIDs) or colchicine. Lowering SUA levels below deposition threshold either by dietary modification or using serum uric acid lowering drugs is the main goal in management of gout. This results in dissolution of MSU crystals preventing further attacks
Males or females aged < 18 years.
All patients are diagnosed to have gout with serum uric acid < 7 mg/dl.
All patients are diagnosed to have obesity with body mass index (BMI) ≥ 30 kg/m2.
The presence of any type of diabetes mellitus.
Patients with drug-induced hyperuriceamia (those taking anti-TB agents, low dose aspirin, cytotoxic chemotherapy, diuretics, immunosuppressants, fructose, lactate infusion, testosterone or xylitol).
Non-obese patients with BMI >30 kg/m2.
Pregnant or lactating women.
Mostafa Bahaa
Lead sponsor
Tanta University
Sponsor institution
Dalia Naser Abdel-Sadek Safa , Faculty of Pharmacy, Tanta University
Collaborator
Sahar Mohamed Elhaggar, Faculty of Pharmacy, Tanta University
Collaborator
Tarek Mohamed Abd-Elazez Nasr-Allah, Faculty of Medicine - Al-Azhar University
Collaborator