Comparative Efficacy Of Intraductal Antibiotic During ERCP In Acute Cholangitis

ConditionsAcute Cholangitis Biliary Tract Infection Biliary Obstruction Choledocholithiasis Malignant Biliary Stricture

Trial statusRecruiting

Trial phasePhase 2

Trial typeInterventional

Biological sexAll

Age18+

SponsorNational University of Malaysia

About this trial

Does intraductal administration of antibiotics during endoscopic retrograde cholangiopancreatography (ERCP), in addition to standard systemic antibiotic therapy, improve clinical outcomes in patients with acute cholangitis compared with standard systemic antibiotic therapy alone?

Eligibility criteria

Qualifiers

The patients diagnosed with mild and moderate acute cholangitis based on TG 18

Planned for ERCP within 48 hours

18 years old and above

Disqualifiers

Severe acute cholangitis

History of antibiotic hypersensitivity

Receiving cancer chemotherapy, steroids, or immunosuppressive agents

Concomitant infections

Trial design

Treatments tested in this trial

Gentamicin - single dose
Distilled water

Treatment groups

172 Participants

are divided into 2 treatment groups

Locations

Hospital Canselor Tuanku Muhriz UKM56000, CherasKuala Lumpur, Malaysia

Sponsors and collaborators

National University of Malaysia

Lead sponsor

Source ClinicalTrials.gov