[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100629247":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":13,"studyPopulation":13,"armGroups":25,"interventions":38,"overallOfficials":13,"centralContacts":51,"locations":58,"responsibleParty":78,"collaborators":13,"id":80,"slug":13,"hasResults":81,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":81,"sex":87,"minAge":88,"maxAge":89,"enrollmentInfo":90,"targetDuration":13,"studyType":93,"phases":94,"briefSummary":96,"conditions":97,"keywords":13,"overallStatus":60,"whyStopped":13,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"Misr University for Science and Technology","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"Vancouver Scar Scale","The study used the standard Vancouver Scar Scale, which evaluates four characteristics of scars:\n\nTotal Score Range: 0 (normal skin) to 13 (severe hypertrophic scar)","4 months",null,{"allocation":15,"interventionModel":16,"interventionModelDescription":13,"primaryPurpose":17,"observationalModel":13,"timePerspective":13,"maskingInfo":18},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":19,"maskingDescription":20,"whoMasked":21},"TRIPLE","Masking Description",[22,23,24],"PARTICIPANT","CARE_PROVIDER","OUTCOMES_ASSESSOR",[26,33],{"label":27,"type":28,"description":29,"interventionNames":30},"Fractional Carbon Dioxide Laser Combined with Polydeoxyribonucleotide (PDRN)","ACTIVE_COMPARATOR","includes patients who will be enrolled for PDRN injection into the surgical scar",[31,32],"Drug: Polydeoxyribonucleotide","Device: Fractional CO2 laser assisted PDT",{"label":34,"type":35,"description":36,"interventionNames":37},"Fractional CO₂ laser therapy with placebo saline injection","PLACEBO_COMPARATOR","includes patients who will be enrolled for placebo saline injection into the surgical scar",[32],[39,44],{"type":40,"name":41,"description":42,"armGroupLabels":43,"otherNames":13},"DRUG","Polydeoxyribonucleotide","intralesional PDRN injections",[27],{"type":45,"name":46,"description":47,"armGroupLabels":48,"otherNames":49},"DEVICE","Fractional CO2 laser assisted PDT","Fractional carbon dioxide (CO₂) laser therapy for facial scars",[34,27],[50],"co2 laser",[52],{"name":53,"role":54,"phone":55,"phoneExt":56,"email":57},"Omnia Tarek Hosni","CONTACT","01117196173","002","200048686@must.edu.eg",[59],{"facility":5,"status":60,"city":61,"state":13,"zip":13,"country":62,"countryCode":63,"cosmosGeoPoint":64,"geoPoint":69,"contacts":70},"RECRUITING","Giza","Egypt","EG",{"type":65,"coordinates":66},"Point",[67,68],31.20861,30.00944,{"lat":68,"lon":67},[71,75],{"name":72,"role":54,"phone":73,"phoneExt":56,"email":74},"Abeer Mohamed Kamal, Phd of OMFS","01005168009","abeer.kamal@must.edu.eg",{"name":76,"role":77,"phone":13,"phoneExt":13,"email":13},"Omnia Tarek Hosni, Bachelor Degree","PRINCIPAL_INVESTIGATOR",{"type":77,"investigatorFullName":53,"investigatorTitle":79,"investigatorAffiliation":5,"oldNameTitle":13,"oldOrganization":13},"Demonstrator in Oral & Maxillofacial Surgery Department, MUST","100629247",false,"NCT07472192","Comparative Study for Facial Scar Remodeling Using Fractional Carbon Dioxide Laser Combined With PDRN Versus Fractional CO₂ Laser","Comparative Study for Facial Scar Remodeling Using Fractional Carbon Dioxide Laser Combined With Polydeoxyribonucleotide (PDRN) Versus Fractional CO₂ Laser: A Randomized Controlled Clinical Study","PDRN CO2 LASER","Inclusion Criteria:\n\n* Age Limitations: Participants must be between 18 and 50 years of age.\n* Recently cut wounds or surgical scars from about (1-6 months).\n* Consent to Participate: Willingness to provide informed consent and engage in all aspects of the study.\n\nExclusion Criteria:\n\n* Pregnancy or breastfeeding at the time of study.\n* Known allergy to PDRN.\n* Medication use that could affect wound healing or inflammation, such as:\n\n  * Isotretinoin.\n  * Anticancer drugs.\n  * High-dose corticosteroids.\n  * Anticoagulants.\n* Uncontrolled medical diseases (e.g., unstable diabetes, cardiac conditions).","ALL","18 Years","50 Years",{"count":91,"type":92},36,"ESTIMATED","INTERVENTIONAL",[95],"PHASE2","Facial scars are frequently deemed unpleasant and can profoundly impact a patient's psychological health. This study compares the effectiveness, safety, and capacity to speed up scar healing in the maxillofacial region between fractional carbon dioxide (CO₂) laser therapy alone and polydeoxyribonucleotide (PDRN) combined with CO₂ laser therapy.",[98],"Facial Scarring","2026-03-11",{"date":101,"type":102},"2026-03-16","ACTUAL",{"date":104,"type":102},"2026-03-01",{"date":106,"type":92},"2026-07-01",{"name":5,"class":6},1]