[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100640253":3},{"organization":4,"outcomesModule":7,"designInfo":21,"detailedDescription":30,"studyPopulation":20,"armGroups":31,"interventions":42,"overallOfficials":20,"centralContacts":51,"locations":57,"responsibleParty":71,"collaborators":20,"id":75,"slug":20,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":76,"sex":82,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":20,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":94,"overallStatus":96,"whyStopped":20,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"Liaquat National Hospital & Medical College","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":20},[9],{"measure":10,"description":11,"timeFrame":12},"Mean Arterial Pressure","Difference in mean arterial pressure between Group B and Group F","Baseline and up to 120 minutes",[14,17],{"measure":15,"description":16,"timeFrame":12},"Hypotension and bradycardia","Incidence of hypotension and bradycardia after spinal Anesthesia between Group B and Group F",{"measure":18,"description":19,"timeFrame":12},"Requirement of vasopressors","Requirements of vasopressors if mean arterial pressure falls below 60mmHg during the procedure and up to 120 minutes",null,{"allocation":22,"interventionModel":23,"interventionModelDescription":20,"primaryPurpose":24,"observationalModel":20,"timePerspective":20,"maskingInfo":25},"RANDOMIZED","CROSSOVER","PREVENTION",{"masking":26,"maskingDescription":20,"whoMasked":27},"DOUBLE",[28,29],"PARTICIPANT","INVESTIGATOR","Assesment of hemodynamic changes like heart rate and blood pressure with hyperbaric bupivacaine in spinal anesthesia when given in fractionanted versus bolus dose manner",[32,38],{"label":33,"type":34,"description":35,"interventionNames":36},"Group B (Bolus)","ACTIVE_COMPARATOR","Group B patients will be given a bolus dose of hyperbaric bupivacaine in a bolus fashion mean all of calculated drug will be given in one shot",[37],"Drug: Spinal Anesthesia (bupivacaine)",{"label":39,"type":34,"description":40,"interventionNames":41},"Group F (Fractionated)","In group F Spinal Anesthesia will be given as 2\u002F3 of the initial dose will be give and then after 90 seconds remaining 1\u002F3 dose will be given of hyperbaric bupivacaine.",[37],[43,48],{"type":44,"name":45,"description":46,"armGroupLabels":47,"otherNames":20},"DRUG","Spinal Anesthesia (bupivacaine)","In this group B spinal Anesthesia will be given in one single shot",[33],{"type":44,"name":45,"description":49,"armGroupLabels":50,"otherNames":20},"In this intervention spinal Anesthesia of bupivacaine will be given in a fractionated manner that is 2\u002F3 of dose initially and then 1\u002F3 after 90 seconds",[39],[52],{"name":53,"role":54,"phone":55,"phoneExt":20,"email":56},"Usama, MBBS","CONTACT","+923008978791","bhurgriusama@gmail.com",[58],{"facility":59,"status":20,"city":60,"state":61,"zip":62,"country":63,"countryCode":64,"cosmosGeoPoint":65,"geoPoint":70,"contacts":20},"Liaquat National Hospital","Karachi","Sindh","74000","Pakistan","PK",{"type":66,"coordinates":67},"Point",[68,69],67.0104,24.8608,{"lat":69,"lon":68},{"type":72,"investigatorFullName":73,"investigatorTitle":74,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"PRINCIPAL_INVESTIGATOR","Usama Bhurgri","Principal Investigator","100640253",false,"NCT07616882","Comparison of Hemodynamic Effects of Bupivacaine in Spinal Anesthesia","Comparison of Hemodynamic Effects of Fractionated Dose Versus Bolus Dose of Hyperbaric Bupivacaine (0.5%) in Spinal Anesthesia for Lower Limb Surgery","Nill","Inclusion Criteria:\n\n* ASA I and II\n* Adults 18 to 60 years of age of either gender\n* height from 160 to 182cm and BMI from 15 to 29.9kg\u002Fm2\n\nExclusion Criteria:\n\n* ASA III and IV\n* Refusal of consent\n* any known renal, hepatic, cardiac or cerebrovascular disease\n* hypersensitivity to local anaesthetics drug\n* spinal deformity or any contra indications to spinal anesthesia","ALL","18 Years","60 Years",{"count":86,"type":87},100,"ESTIMATED","INTERVENTIONAL",[90],"PHASE2","To assess hemodynamic changes with hyperbaric bupivacaine with spinal anesthesia",[93],"Hemondynamic Changes in Spinal Anesthesia",[95],"Spinal ansethesia, Fractionated, Bolus","NOT_YET_RECRUITING","2026-05-26",{"date":99,"type":100},"2026-06-01","ACTUAL",{"date":102,"type":87},"2027-04-01",{"date":104,"type":87},"2027-10-01",{"name":5,"class":6},1]