[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100592431":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":30,"centralContacts":30,"locations":30,"responsibleParty":37,"collaborators":30,"id":41,"slug":30,"hasResults":42,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":30,"eligibilityCriteria":46,"healthyVolunteers":42,"sex":47,"minAge":48,"maxAge":49,"enrollmentInfo":50,"targetDuration":30,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":30,"overallStatus":59,"whyStopped":30,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":30},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"35% Topical Bromelain in Orabase","EXPERIMENTAL","Participants in this group will receive 35% bromelain gel incorporated into an orabase adhesive medium.",[13],"Dietary Supplement: 35% Topical Bromelain in Orabase",{"label":15,"type":10,"description":16,"interventionNames":17},"50% Topical Bromelain in Orabase","Participants assigned to this group will be treated with 50% bromelain gel formulated in orabase.",[18],"Dietary Supplement: 50% Topical Bromelain in Orabase",{"label":20,"type":21,"description":22,"interventionNames":23},"0.1% Topical Triamcinolone Acetonide in Orabase","ACTIVE_COMPARATOR","This group will receive the standard treatment of 0.1% triamcinolone acetonide in orabase, commonly used for managing Recurrent Aphthous Stomatitis.",[24],"Drug: 0.1% Topical Triamcinolone Acetonide in Orabase",[26,31,33],{"type":27,"name":9,"description":28,"armGroupLabels":29,"otherNames":30},"DIETARY_SUPPLEMENT","Bromelain is a natural proteolytic enzyme derived from pineapple, recognized for its broad range of pharmacological properties. It exhibits significant anti-inflammatory effects by reducing edema. In addition to its anti-inflammatory activity, bromelain possesses antioxidant and analgesic properties.",[9],null,{"type":27,"name":15,"description":28,"armGroupLabels":32,"otherNames":30},[15],{"type":34,"name":20,"description":35,"armGroupLabels":36,"otherNames":30},"DRUG","Triamcinolone acetonide in orabase, a corticosteroid-based standard treatment for Recurrent Aphthous Stomatitis (RAS), is used for its strong anti-inflammatory and immunosuppressive effects. In this study, it serves as the conventional treatment against the novel therapy",[20],{"type":38,"investigatorFullName":39,"investigatorTitle":40,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"PRINCIPAL_INVESTIGATOR","Omnia Ahmed Ayoub Mohamed","Master's Student in Oral Medicine","100592431",false,"NCT06993337","Effect of Topical Bromelain Versus Topical Corticosteroids in the Management of Recurrent Aphthous Stomatitis","Evaluation of Topical Bromelain Versus Topical Corticosteroids in Management of Recurrent Aphthous Stomatitis: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults aged 18-60 years.\n* Diagnosed with RAS.\n* Onset of ulcer within the last 48 hours.\n* Willingness to participate and provide informed consent.\n\nExclusion Criteria:\n\n* History of hematological deficiencies, GIT disorders, Behcet's disease and major systemic diseases.\n* Pregnant or breastfeeding patients.\n* Previous treatment for the current ulcer episode.","ALL","18 Years","60 Years",{"count":51,"type":52},63,"ESTIMATED","INTERVENTIONAL",[55],"PHASE2","Bromelain, a natural product, exhibits anti-inflammatory, immunomodulatory, and wound-healing properties. However, its efficacy in treating oral mucosal ulcers remains unexplored. This study aims to evaluate the effect of bromelain as a safe alternate for management of RAS.",[58],"Recurrent Aphthous Stomatitis","NOT_YET_RECRUITING","2025-05-25",{"date":62,"type":63},"2025-05-28","ACTUAL",{"date":65,"type":52},"2025-06-15",{"date":67,"type":52},"2026-06-15",{"name":5,"class":6}]