[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100576473":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":23,"studyPopulation":13,"armGroups":24,"interventions":35,"overallOfficials":43,"centralContacts":48,"locations":57,"responsibleParty":74,"collaborators":13,"id":77,"slug":13,"hasResults":78,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":84,"sex":85,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":13,"studyType":91,"phases":92,"briefSummary":94,"conditions":95,"keywords":13,"overallStatus":60,"whyStopped":13,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"Armed Forces Institute of Dentistry, Pakistan","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"post operative pain after root canal treatment","post operative pain will be assessed using visual analogue scale ( VAS) from 0-10 each patient will be given instruction to access the post operative pain . it will be carried out using a questionnaire.\n\nVAS 0-1 = No pain 2-3 = mild pain 4-6 = moderate pain 7-10 = severe pain pain recording will be done at 6 hrs , 24 hrs, 48hrs and 72 hrs. ( participants to be contacted by investigator at each point to check on them and remind them to record their pain ). The given questionnaire shall be collected when the participant comes for final restoration after 1 week","1 week",null,{"allocation":15,"interventionModel":16,"interventionModelDescription":13,"primaryPurpose":17,"observationalModel":13,"timePerspective":13,"maskingInfo":18},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":19,"maskingDescription":13,"whoMasked":20},"DOUBLE",[21,22],"PARTICIPANT","INVESTIGATOR","Diagnostic procedures to include patients history taking , clinical and radiographic with all findings being recorded in patients .\n\npatients diagnosed with symptomatic irreversible pulpitis with symptomatic apical periodontitis.\n\npatients will be asked to rate their pre treatment pain on visual analogue scale from 0-10\n\npatients with pain score \\\u003C8 will be considered\n\nAnesthesia and isolation : after administration of local anesthesia , rubber dam application will be done\n\nAcess cavity : acess will be gained with round bur using air turbune handpiece with copious water cooling\n\nWorking length : a size 10k file will be inserted into the canal to determine the working length with the help of radiograph\n\nCleaning and shaping : Extirpation of pulp will be done followed by canal preparation with manual and endodontic motor using naocl and EDTA .\n\nfinal irrigation will be performed using 17% EDTA and 5.25% NaOCl\n\nPatients will be divided into 2 group in control group : final irrigation will be done using 5ml of saline at room temperature in cold group : final irrigation will be done using 5ml of cold saline at 2.5°C\n\nthe solution will be stored in the refrigerator until use irrigation will be performed for 5 min in both groups using 27 G beveled needle tip inserted 2mm short of WL.\n\nObturation ; In both groups , canals will be dried with paper points and obturated using gutta percha cones with zinc oxide eugenol sealer\n\nRestoration : acces cavity will be restroed with direct composite restoration or high viscosity glass ionomer cement\n\neach patient will be given instruction to acess the post operative pain .",[25,31],{"label":26,"type":27,"description":28,"interventionNames":29},"normal saline group","EXPERIMENTAL","In control group , canals will be irrigated with 5ml of normal saline at room temperature",[30],"Drug: Irrigation Solution",{"label":32,"type":27,"description":33,"interventionNames":34},"cryotherapy (cold saline group)","in cold saline group , canals will be irrigated with 5 ml of cold saline at a temperature of 2.5° C",[30],[36],{"type":37,"name":38,"description":39,"armGroupLabels":40,"otherNames":41},"DRUG","Irrigation Solution","normal saline will be used as irrigation solution",[32,26],[42],"normal saline irrigant",[44],{"name":45,"affiliation":46,"role":47},"Hira Amjad, BDS","Armed Forces Institude Of Dentistry","PRINCIPAL_INVESTIGATOR",[49,53],{"name":45,"role":50,"phone":51,"phoneExt":13,"email":52},"CONTACT","03345294071","anmolamjad03@gmail.com",{"name":54,"role":50,"phone":55,"phoneExt":13,"email":56},"Kanza Zafar, BDS","03337808809","kanzazafar6@gmail.com",[58],{"facility":59,"status":60,"city":61,"state":62,"zip":63,"country":64,"countryCode":65,"cosmosGeoPoint":66,"geoPoint":71,"contacts":72},"Armed Forces Institute of Dentistry","RECRUITING","Rawalpindi","Punjab Province","46000","Pakistan","PK",{"type":67,"coordinates":68},"Point",[69,70],73.0479,33.59733,{"lat":70,"lon":69},[73],{"name":45,"role":50,"phone":51,"phoneExt":13,"email":52},{"type":47,"investigatorFullName":75,"investigatorTitle":76,"investigatorAffiliation":5,"oldNameTitle":13,"oldOrganization":13},"Hira Amjad","Dr. Hira Amjad , Principal investigator and Resident Operative Dentistry and Endodontics","100576473",false,"NCT06785753","Effectiveness of Cryotherapy on Endodontic Pain","Effectiveness of Intracanal Cryotherapy on Post Operative Pain After Root Canal Therapy in Patients with Symptomatic Apical Periodontitis","Cy","Inclusion Criteria:\n\n* patients with symptomatic irreversible pulpitis and symptomatic apical periodontitis\n* maxillary or mandibular single rooted teeth\n* systemically healthy patients\n* patients having pain score \\\u003C 8\n\nExclusion Criteria:\n\n* patients on preoperative analgesics or antibiotics within past 12 hours\n* teeth with calcified canals and previously treated teeth\n* tooth with immature apices or resorption\n* patients allergic to local anesthesia\n* pregnant or lactating mothers\n* patients who are immunocompromised .",true,"ALL","20 Years","40 Years",{"count":89,"type":90},60,"ESTIMATED","INTERVENTIONAL",[93],"PHASE2","This is a randomized , prospective , control trial to assess the effectiveness of intracanal cryotherapy on post operative pain after root canal treatment in patients with symptomatic apical periodontitis",[96],"Post Operative Pain","2025-01-19",{"date":99,"type":100},"2025-01-21","ACTUAL",{"date":102,"type":100},"2024-11-07",{"date":104,"type":90},"2025-05-08",{"name":5,"class":6},1]