[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100616297":3},{"organization":4,"armGroups":7,"interventions":27,"overallOfficials":32,"centralContacts":43,"locations":49,"responsibleParty":413,"collaborators":32,"id":415,"slug":32,"hasResults":416,"nctId":417,"briefTitle":418,"officialTitle":419,"acronym":32,"eligibilityCriteria":420,"healthyVolunteers":416,"sex":421,"minAge":422,"maxAge":423,"enrollmentInfo":424,"targetDuration":32,"studyType":427,"phases":428,"briefSummary":430,"conditions":431,"keywords":435,"overallStatus":324,"whyStopped":32,"lastUpdateSubmitDate":437,"lastUpdatePostDateStruct":438,"startDateStruct":441,"completionDateStruct":442,"leadSponsor":444,"locationsCount":445},{"fullName":5,"class":6},"Atom Therapeutics Co., Ltd","INDUSTRY",[8,14,19,23],{"label":9,"type":10,"description":11,"interventionNames":12},"Placebo group","PLACEBO_COMPARATOR","Existing lipid-lowering maintenance medications unchanged.",[13],"Drug: Placebo",{"label":15,"type":16,"description":11,"interventionNames":17},"ABP-745 Dose A","EXPERIMENTAL",[18],"Drug: ABP-745 Dose A",{"label":20,"type":16,"description":11,"interventionNames":21},"ABP-745 Dose B",[22],"Drug: ABP-745 Dose B",{"label":24,"type":16,"description":11,"interventionNames":25},"ABP-745 Dose C",[26],"Drug: ABP-745 Dose C",[28,33,37,40],{"type":29,"name":15,"description":30,"armGroupLabels":31,"otherNames":32},"DRUG","ABP-745 Dose A - tablets (PO), low dose , QD",[15],null,{"type":29,"name":34,"description":35,"armGroupLabels":36,"otherNames":32},"Placebo","ABP-745 placebo - tablets (PO), non-active,QD",[9],{"type":29,"name":20,"description":38,"armGroupLabels":39,"otherNames":32},"ABP-745 Dose B - tablets (PO), Midum dose, QD",[20],{"type":29,"name":24,"description":41,"armGroupLabels":42,"otherNames":32},"ABP-745 Dose C - tablets (PO), High dose, QD",[24],[44],{"name":45,"role":46,"phone":47,"phoneExt":32,"email":48},"Qiang Shi","CONTACT","86+ 19117302212","qiang.shi@atombp.com",[50,70,86,101,117,134,148,159,169,180,192,200,208,216,227,238,249,257,265,276,287,295,306,314,322,331,342,353,364,375,386,394,402],{"facility":51,"status":52,"city":53,"state":54,"zip":55,"country":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"Cardiovascular Research Foundation of Southern California","NOT_YET_RECRUITING","Beverly Hills","California","90210","United States",{"type":58,"coordinates":59},"Point",[60,61],-118.40036,34.07362,{"lat":61,"lon":60},[64,68],{"name":65,"role":46,"phone":66,"phoneExt":32,"email":67},"Ronald P. Karlsberg","(310) 278-3400","Karlsberg@cvmg.com",{"name":65,"role":69,"phone":32,"phoneExt":32,"email":32},"PRINCIPAL_INVESTIGATOR",{"facility":71,"status":52,"city":72,"state":54,"zip":73,"country":56,"cosmosGeoPoint":74,"geoPoint":78,"contacts":79},"Cardiovascular Institute of San Diego INC","San Diego","91911",{"type":58,"coordinates":75},[76,77],-117.16472,32.71571,{"lat":77,"lon":76},[80,84],{"name":81,"role":46,"phone":82,"phoneExt":32,"email":83},"Milind M. Parikh, M.D.","619-616-2100","Milind.Parikh@cvisd.com",{"name":85,"role":69,"phone":32,"phoneExt":32,"email":32},"Milind Parikh, M.D.",{"facility":87,"status":52,"city":88,"state":54,"zip":89,"country":56,"cosmosGeoPoint":90,"geoPoint":94,"contacts":95},"The Lundquist Institute","Torrance","90502",{"type":58,"coordinates":91},[92,93],-118.34063,33.83585,{"lat":93,"lon":92},[96,100],{"name":97,"role":46,"phone":98,"phoneExt":32,"email":99},"Matthew Budoff, M.D.","(424) 201-3000","mbudoff@lundquist.org",{"name":97,"role":69,"phone":32,"phoneExt":32,"email":32},{"facility":102,"status":52,"city":103,"state":104,"zip":105,"country":56,"cosmosGeoPoint":106,"geoPoint":110,"contacts":111},"Washington University School of Medicine, St.louis","St Louis","Missouri","63130",{"type":58,"coordinates":107},[108,109],-90.19789,38.62727,{"lat":109,"lon":108},[112,116],{"name":113,"role":46,"phone":114,"phoneExt":32,"email":115},"Farhan M. Katchi, M.D.","314-362-1291","katchif@wustl.edu",{"name":113,"role":69,"phone":32,"phoneExt":32,"email":32},{"facility":118,"status":52,"city":119,"state":120,"zip":121,"country":122,"cosmosGeoPoint":123,"geoPoint":127,"contacts":128},"NovaTrails","Newcastle","New South Wales","2290","Australia",{"type":58,"coordinates":124},[125,126],151.7801,-32.92953,{"lat":126,"lon":125},[129,132],{"name":130,"role":46,"phone":32,"phoneExt":32,"email":131},"Oscar Cumming, M.D.","Renata.fuljahn@novatrials.com.au",{"name":133,"role":69,"phone":32,"phoneExt":32,"email":32},"Oscar Cumming",{"facility":135,"status":52,"city":136,"state":137,"zip":138,"country":122,"cosmosGeoPoint":139,"geoPoint":143,"contacts":144},"University of the Sunshine Coast Clinical Trials Unit - Morayfield","Morayfield","Queensland","4506",{"type":58,"coordinates":140},[141,142],152.94907,-27.10876,{"lat":142,"lon":141},[145,147],{"name":146,"role":46,"phone":32,"phoneExt":32,"email":32},"Chris Moller, M.D.",{"name":146,"role":69,"phone":32,"phoneExt":32,"email":32},{"facility":149,"status":52,"city":150,"state":32,"zip":32,"country":122,"cosmosGeoPoint":151,"geoPoint":155,"contacts":156},"Core Research Group Pty Ltd","Brisbane",{"type":58,"coordinates":152},[153,154],153.02809,-27.46794,{"lat":154,"lon":153},[157],{"name":158,"role":69,"phone":32,"phoneExt":32,"email":32},"Colquhoun David, M.D.",{"facility":160,"status":52,"city":150,"state":32,"zip":32,"country":122,"cosmosGeoPoint":161,"geoPoint":163,"contacts":164},"UniSC Clinical Trials (Brisbane)",{"type":58,"coordinates":162},[153,154],{"lat":154,"lon":153},[165,168],{"name":166,"role":46,"phone":32,"phoneExt":32,"email":167},"Nsahai Sahai, M.D.","nsahai@usc.edu.au",{"name":166,"role":69,"phone":32,"phoneExt":32,"email":32},{"facility":170,"status":52,"city":171,"state":32,"zip":32,"country":122,"cosmosGeoPoint":172,"geoPoint":176,"contacts":177},"Cognivus","Wahroonga",{"type":58,"coordinates":173},[174,175],151.11561,-33.71816,{"lat":175,"lon":174},[178],{"name":179,"role":69,"phone":32,"phoneExt":32,"email":32},"Elizabeth Shaw, MBBS",{"facility":181,"status":52,"city":182,"state":32,"zip":32,"country":183,"cosmosGeoPoint":184,"geoPoint":188,"contacts":189},"Beijing Friendship Hospital, Capital Medical University","Beijing","China",{"type":58,"coordinates":185},[186,187],116.39723,39.9075,{"lat":187,"lon":186},[190],{"name":191,"role":69,"phone":32,"phoneExt":32,"email":32},"Ping Wang",{"facility":193,"status":52,"city":182,"state":32,"zip":32,"country":183,"cosmosGeoPoint":194,"geoPoint":196,"contacts":197},"Peking Union Medical College Hospital",{"type":58,"coordinates":195},[186,187],{"lat":187,"lon":186},[198],{"name":199,"role":69,"phone":32,"phoneExt":32,"email":32},"Zhenyu Liu",{"facility":201,"status":52,"city":182,"state":32,"zip":32,"country":183,"cosmosGeoPoint":202,"geoPoint":204,"contacts":205},"Peking University First Hospital",{"type":58,"coordinates":203},[186,187],{"lat":187,"lon":186},[206],{"name":207,"role":69,"phone":32,"phoneExt":32,"email":32},"Yan Zhang",{"facility":209,"status":52,"city":182,"state":32,"zip":32,"country":183,"cosmosGeoPoint":210,"geoPoint":212,"contacts":213},"Xuanwu Hospital Capital Medical University",{"type":58,"coordinates":211},[186,187],{"lat":187,"lon":186},[214],{"name":215,"role":69,"phone":32,"phoneExt":32,"email":32},"Chunlin Yin",{"facility":217,"status":52,"city":218,"state":32,"zip":32,"country":183,"cosmosGeoPoint":219,"geoPoint":223,"contacts":224},"Dalian Second Hospital","Dalian",{"type":58,"coordinates":220},[221,222],121.60222,38.91222,{"lat":222,"lon":221},[225],{"name":226,"role":69,"phone":32,"phoneExt":32,"email":32},"Xin Zhao",{"facility":228,"status":52,"city":229,"state":32,"zip":32,"country":183,"cosmosGeoPoint":230,"geoPoint":234,"contacts":235},"Guangdong Province Hospital","Guangzhou",{"type":58,"coordinates":231},[232,233],113.25,23.11667,{"lat":233,"lon":232},[236],{"name":237,"role":69,"phone":32,"phoneExt":32,"email":32},"Jiyan Chen",{"facility":239,"status":52,"city":240,"state":32,"zip":32,"country":183,"cosmosGeoPoint":241,"geoPoint":245,"contacts":246},"Sir Run Run Shaw Hospital of Zhejiang University School of Medicine","Hangzhou",{"type":58,"coordinates":242},[243,244],120.16142,30.29365,{"lat":244,"lon":243},[247],{"name":248,"role":69,"phone":32,"phoneExt":32,"email":32},"Guosheng Fu",{"facility":250,"status":52,"city":240,"state":32,"zip":32,"country":183,"cosmosGeoPoint":251,"geoPoint":253,"contacts":254},"The First Affiliated Hospital of Zhejiang University school of medicine",{"type":58,"coordinates":252},[243,244],{"lat":244,"lon":243},[255],{"name":256,"role":69,"phone":32,"phoneExt":32,"email":32},"Xiaogang Guo",{"facility":258,"status":52,"city":240,"state":32,"zip":32,"country":183,"cosmosGeoPoint":259,"geoPoint":261,"contacts":262},"Zhejiang Provincial People's Hospital",{"type":58,"coordinates":260},[243,244],{"lat":244,"lon":243},[263],{"name":264,"role":69,"phone":32,"phoneExt":32,"email":32},"Lihong Wang",{"facility":266,"status":52,"city":267,"state":32,"zip":32,"country":183,"cosmosGeoPoint":268,"geoPoint":272,"contacts":273},"Jinan Central Hospital","Jinan",{"type":58,"coordinates":269},[270,271],116.99722,36.66833,{"lat":271,"lon":270},[274],{"name":275,"role":69,"phone":32,"phoneExt":32,"email":32},"Guohai Su",{"facility":277,"status":52,"city":278,"state":32,"zip":32,"country":183,"cosmosGeoPoint":279,"geoPoint":283,"contacts":284},"Jiangsu Province Hospital","Nanjing",{"type":58,"coordinates":280},[281,282],118.77778,32.06167,{"lat":282,"lon":281},[285],{"name":286,"role":69,"phone":32,"phoneExt":32,"email":32},"Chunjian Li",{"facility":288,"status":52,"city":278,"state":32,"zip":32,"country":183,"cosmosGeoPoint":289,"geoPoint":291,"contacts":292},"Nanjing Drum Tower Hospital",{"type":58,"coordinates":290},[281,282],{"lat":282,"lon":281},[293],{"name":294,"role":69,"phone":32,"phoneExt":32,"email":32},"Biao Xu",{"facility":296,"status":52,"city":297,"state":32,"zip":32,"country":183,"cosmosGeoPoint":298,"geoPoint":302,"contacts":303},"Huashan Hospital Fudan University","Shanghai",{"type":58,"coordinates":299},[300,301],121.45806,31.22222,{"lat":301,"lon":300},[304],{"name":305,"role":69,"phone":32,"phoneExt":32,"email":32},"Jian Li",{"facility":307,"status":52,"city":297,"state":32,"zip":32,"country":183,"cosmosGeoPoint":308,"geoPoint":310,"contacts":311},"Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine",{"type":58,"coordinates":309},[300,301],{"lat":301,"lon":300},[312],{"name":313,"role":69,"phone":32,"phoneExt":32,"email":32},"Jun Bu",{"facility":315,"status":52,"city":297,"state":32,"zip":32,"country":183,"cosmosGeoPoint":316,"geoPoint":318,"contacts":319},"Shanghai General Hospital",{"type":58,"coordinates":317},[300,301],{"lat":301,"lon":300},[320],{"name":321,"role":69,"phone":32,"phoneExt":32,"email":32},"Shaowen Liu",{"facility":323,"status":324,"city":297,"state":32,"zip":32,"country":183,"cosmosGeoPoint":325,"geoPoint":327,"contacts":328},"The Zhongshan Hospital Affiliated to Fudan University","RECRUITING",{"type":58,"coordinates":326},[300,301],{"lat":301,"lon":300},[329],{"name":330,"role":69,"phone":32,"phoneExt":32,"email":32},"Junbo Ge, M.D.",{"facility":332,"status":52,"city":333,"state":32,"zip":32,"country":183,"cosmosGeoPoint":334,"geoPoint":338,"contacts":339},"The First Affiliated Hospital of Soochow University","Suzhou",{"type":58,"coordinates":335},[336,337],120.59538,31.30408,{"lat":337,"lon":336},[340],{"name":341,"role":69,"phone":32,"phoneExt":32,"email":32},"Tingbo Jiang",{"facility":343,"status":52,"city":344,"state":32,"zip":32,"country":183,"cosmosGeoPoint":345,"geoPoint":349,"contacts":350},"Tianjin General Hospital","Tianjin",{"type":58,"coordinates":346},[347,348],117.17667,39.14222,{"lat":348,"lon":347},[351],{"name":352,"role":69,"phone":32,"phoneExt":32,"email":32},"Qing Yang",{"facility":354,"status":52,"city":355,"state":32,"zip":32,"country":183,"cosmosGeoPoint":356,"geoPoint":360,"contacts":361},"Renmin Hospital of Wuhan University","Wuhan",{"type":58,"coordinates":357},[358,359],114.26667,30.58333,{"lat":359,"lon":358},[362],{"name":363,"role":69,"phone":32,"phoneExt":32,"email":32},"Xiaoyan Li",{"facility":365,"status":52,"city":366,"state":32,"zip":32,"country":183,"cosmosGeoPoint":367,"geoPoint":371,"contacts":372},"Wuxi People's Hospital","Wuxi",{"type":58,"coordinates":368},[369,370],120.28857,31.56887,{"lat":370,"lon":369},[373],{"name":374,"role":69,"phone":32,"phoneExt":32,"email":32},"Ruxing Wang",{"facility":376,"status":52,"city":377,"state":32,"zip":32,"country":183,"cosmosGeoPoint":378,"geoPoint":382,"contacts":383},"Shaanxi Provincial People's Hospital","Xi'an",{"type":58,"coordinates":379},[380,381],108.92861,34.25833,{"lat":381,"lon":380},[384],{"name":385,"role":69,"phone":32,"phoneExt":32,"email":32},"Junkui Wang",{"facility":387,"status":52,"city":377,"state":32,"zip":32,"country":183,"cosmosGeoPoint":388,"geoPoint":390,"contacts":391},"The First Affiliated Hospital of Xian Jiaotong University",{"type":58,"coordinates":389},[380,381],{"lat":381,"lon":380},[392],{"name":393,"role":69,"phone":32,"phoneExt":32,"email":32},"Zuyi Yuan",{"facility":395,"status":52,"city":377,"state":32,"zip":32,"country":183,"cosmosGeoPoint":396,"geoPoint":398,"contacts":399},"The Second Affiliated Hospital of Xi'an Jiaotong University",{"type":58,"coordinates":397},[380,381],{"lat":381,"lon":380},[400],{"name":401,"role":69,"phone":32,"phoneExt":32,"email":32},"Jie Deng",{"facility":403,"status":52,"city":404,"state":32,"zip":32,"country":183,"cosmosGeoPoint":405,"geoPoint":409,"contacts":410},"The Affiliated Hospital of Xuzhou Medical College","Xuzhou",{"type":58,"coordinates":406},[407,408],117.28386,34.20442,{"lat":408,"lon":407},[411],{"name":412,"role":69,"phone":32,"phoneExt":32,"email":32},"Dengfeng Pan",{"type":414,"investigatorFullName":32,"investigatorTitle":32,"investigatorAffiliation":32,"oldNameTitle":32,"oldOrganization":32},"SPONSOR","100616297",false,"NCT07303777","Efficacy, Safety, and PopPK Profile of ABP-745 in Patients With Atherosclerosis","A Multicenter, Randomized, Double-blind, Placebo-controlled Phase II Study to Evaluate the Efficacy, Safety, and Population Pharmacokinetics (PopPK) Profile of ABP-745 in Patients With Atherosclerosis","Inclusion Criteria:\n\nUnless otherwise specified, subjects must meet all of the following criteria at screening:\n\n* Diagnosed with coronary at herosclerosis, and coronary angiography.\n* Male or female at 18-75 years of age (inclusive).\n* Weight ≥40 kg.\n* Currently using any oral lipid-lowering therapy.\n* Able to understand and willing to sign an ICF and comply with study requirements.\n* A woman or man of childbearing potential agreeing to use medically approved contraceptive methods from the screening until 3 months after the last study dose.\n\nExclusion Criteria:\n\nUnless otherwise specified, subjects are excluded from the study if any of the following criteria is met:\n\n* History of stroke within the past 6 months.\n* Uncontrolled arrhythmia within 3 months prior to screening.\n* Evidence of any active or suspected cancer within 3 years prior to the screening.\n* Having undergone any major surgery within 3 months prior to the screening or planning to undergo any major surgery during the study.\n* Presence or suspicion of ongoing of any serious infection.\n* Human immunodeficiency virus (HIV) infection.","ALL","18 Years","75 Years",{"count":425,"type":426},200,"ESTIMATED","INTERVENTIONAL",[429],"PHASE2","This is a multicenter, randomized, double-blind, placebo parallel controlled study to evaluate the preliminary efficacy, safety, and PopPK profile of ABP-745 in patients with ASCVD. Efficacy of ABP-745 in reducing atherosclerotic plaque compared with placebo will be evaluated in participants with ASCVD. The primary efficacy measurement will be assessed at 52W of treatment.",[432,433,434],"Atherosclerosis Cardiovascular Disease","ASCVD","ASCVD Management",[433,436],"ABP-745","2026-04-23",{"date":439,"type":440},"2026-04-28","ACTUAL",{"date":437,"type":440},{"date":443,"type":426},"2028-04",{"name":5,"class":6},33]