[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100519985":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":26,"centralContacts":30,"locations":39,"responsibleParty":71,"collaborators":75,"id":81,"slug":18,"hasResults":82,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":18,"eligibilityCriteria":86,"healthyVolunteers":82,"sex":87,"minAge":88,"maxAge":18,"enrollmentInfo":89,"targetDuration":18,"studyType":92,"phases":93,"briefSummary":95,"conditions":96,"keywords":18,"overallStatus":42,"whyStopped":18,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"University of Iowa","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Essential Amino Acid Supplementation","EXPERIMENTAL","Subjects randomized to intervention arm of this study will receive essential amino acid (EAA)-based oral nutrition supplementation in addition to standard of care postoperative nutrition. Subjects will take 1 scoop (26.7g) of supplement twice daily for 4 weeks after injury. Supplementation will begin within 72 hours of surgical fixation. The EAA-based supplement used in this clinical trial is MEND™ Repair and Recover®.",[13],"Combination Product: Essential Amino Acid Supplementation",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard of Care Postoperative Nutrition","NO_INTERVENTION","Subjects randomized to the control arm of this study will receive no intervention. They will receive standard of care postoperative nutrition.",null,[20],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"COMBINATION_PRODUCT","Powdered supplement that can be mixed into beverage of choice. Ingredients: Zinc, Vitamin A, Vitamin C, Whey Protein, Leucine, Calcium, Vitamin D, Glutamine, Boron, Turmeric, Bioperine, Iron, β-hydroxy β-methylbutyrate (HMB)",[9],[25],"MEND Repair & Recover",[27],{"name":28,"affiliation":5,"role":29},"Michael C Willey, MD","PRINCIPAL_INVESTIGATOR",[31,35],{"name":28,"role":32,"phone":33,"phoneExt":18,"email":34},"CONTACT","319-384-8452","michael-willey@uiowa.edu",{"name":36,"role":32,"phone":37,"phoneExt":18,"email":38},"Ashley S Kochuyt, BS","319-929-3559","ashley-kochuyt@uiowa.edu",[40,55],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"University of Iowa Health Care","RECRUITING","Iowa City","Iowa","52242","United States",{"type":48,"coordinates":49},"Point",[50,51],-91.53017,41.66113,{"lat":51,"lon":50},[54],{"name":36,"role":32,"phone":18,"phoneExt":18,"email":38},{"facility":56,"status":57,"city":58,"state":59,"zip":60,"country":46,"cosmosGeoPoint":61,"geoPoint":65,"contacts":66},"Slocum Center for Orthopedics & Sports Medicine","NOT_YET_RECRUITING","Eugene","Oregon","97401",{"type":48,"coordinates":62},[63,64],-123.08675,44.05207,{"lat":64,"lon":63},[67],{"name":68,"role":32,"phone":69,"phoneExt":18,"email":70},"Tessa Kirkpatrick","5418680658","tessa.kirkpatrick@slocumfoundation.org",{"type":72,"investigatorFullName":73,"investigatorTitle":74,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"SPONSOR_INVESTIGATOR","Michael C Willey","Assistant Professor",[76,79],{"name":77,"class":78},"MEND","UNKNOWN",{"name":80,"class":6},"Slocum Research & Education Foundation","100519985",false,"NCT06050668","Essential Amino Acid Supplementation for Femoral Fragility Fractures","MEND Repair & Recover Clinical Trial","Inclusion Criteria:\n\n* Hospital inpatient\n* Age ≥ 65 years old on admission\n* Low-energy mechanism of injury\n* Diagnosis of femur fracture (OTA 31, 32, or 33 fracture)\n* Indicated for surgical fixation\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Part of a vulnerable population (ex: Incarcerated, Non-English speaking)\n* Cognitive impairment (MMSE score ≤ 17)\n* Electrical medical implant (ex: Pacemaker\u002FDefibrillator, Left Ventricular Assist Device, Cochlear implant, Insulin pump, Pain medication pumps, Spinal cord stimulator)\n* Non-ambulatory prior to injury\n* Inability to consume an oral diet or allergy to supplement ingredients (ex: milk allergy)\n* Concern for inability to complete follow-up\n* Hemi or total arthroplasty (joint replacement)\n* Patients with a historical diagnosis of chronic kidney disease (CKD)","ALL","65 Years",{"count":90,"type":91},60,"ESTIMATED","INTERVENTIONAL",[94],"PHASE2","This trial will evaluate the impact of 4 weeks of postoperative essential amino acid (EAA)-based supplementation on muscle morphology after femoral fragility fracture. This trial will assess the ability of EAA-based to increase skeletal muscle metabolic activity, reduce inflammation, and induce muscle fiber hypertrophy, as well as preserve skeletal muscle mass and physical performance up to 6 months after injury. Participants will be randomized in a 1:1 ratio to 1) standard of care (no dietary intervention) or 2) EAA-based supplementation.",[97,98,99],"Femoral Fracture","Fragility Fracture","Muscle Atrophy","2026-04-14",{"date":102,"type":103},"2026-04-15","ACTUAL",{"date":105,"type":103},"2024-06-17",{"date":107,"type":91},"2026-12",{"name":73,"class":6},2]