The aim is to conduct a randomized controlled trial (RCT) with a high dose arm (1mg/kg) vs a low dose (8mg in total) of steroid (Dexamethasone) given intravenous (IV) after the induction of anesthesia to "High-pain-responders" in patients undergoing VATS lobectomy/segmentectomy.
The hypothesis is that a high dose of Dexamethasone can lower pain when coughing in the morning after VATS lobectomy/segmentectomy, in patients scoring as "High-pain-responders" on the Pain-Catastrophizing-Scale
Age ≥ 18 year
Able to understand written and spoken Danish language
PCS ≥20
Signed written informed consent form.
Patients undergoing systemic glucocorticoid or other immunosuppressive therapies, ex-cluding inhaled steroids.
Individuals with diabetes requiring insulin treatment.
Pregnant or breastfeeding patients.
Patients with known allergies to the study drug.
Rigshospitalet, Denmark
Lead sponsor