[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100509109":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":29,"centralContacts":34,"locations":43,"responsibleParty":57,"collaborators":11,"id":61,"slug":11,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":68,"sex":69,"minAge":70,"maxAge":11,"enrollmentInfo":71,"targetDuration":11,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":11,"overallStatus":46,"whyStopped":11,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"University of Sao Paulo General Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Hypertonic Saline Solution 3,5% (HSS)","ACTIVE_COMPARATOR",null,[13],"Drug: Sodium chloride solution 3,5%",{"label":15,"type":16,"description":11,"interventionNames":17},"Normal Saline Solution (NS)","PLACEBO_COMPARATOR",[18],"Drug: Sodium chloride solution 0,9%",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"DRUG","Sodium chloride solution 3,5%","Patients will receive 150 mL HSS 3,5% intravenous twice daily for 3 days after heart transplantation.",[9],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"Sodium chloride solution 0,9%","Patients will receive 150 mL NS 0,9% intravenous twice daily for 3 days after heart transplantation.",[15],[30],{"name":31,"affiliation":32,"role":33},"Fernando Bacal, PhD","University of Sao Paulo","STUDY_DIRECTOR",[35,40],{"name":36,"role":37,"phone":38,"phoneExt":11,"email":39},"Ciro M Murad, MD","CONTACT","+55 31988988843","ciromurad@hotmail.com",{"name":41,"role":37,"phone":42,"phoneExt":11,"email":11},"Núcleo Transplante Heart Institute \u002F University of Sao Paulo","+55 1126615720",[44],{"facility":45,"status":46,"city":47,"state":11,"zip":11,"country":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Heart Institute, University of São Paulo.","RECRUITING","São Paulo","Brazil",{"type":50,"coordinates":51},"Point",[52,53],-46.63611,-23.5475,{"lat":53,"lon":52},[56],{"name":36,"role":37,"phone":11,"phoneExt":11,"email":39},{"type":58,"investigatorFullName":59,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"SPONSOR_INVESTIGATOR","Fernando Bacal","Director of Heart Transplant Unit (Heart Institute).","100509109",false,"NCT05909150","Hypertonic Saline Solution to Prevent Acute Kidney Injury After Heart Transplantation","Use of Hypertonic Saline Solution to Prevent Acute Kidney Injury After Heart Transplantation","HSS-HTx","Inclusion Criteria:\n\n* Hospitalized patients submitted to orthotopic heart transplantation (HT)\n\nExclusion Criteria:\n\n* Requirement of renal replacement therapy at the time of HT\n* Requirement of extracorporeal membrane oxygenation (ECMO) before or immediately after HT\n* Severe peri-operative mechanical complications\n* Double transplant (e.g. heart-kidney or heart-lung)\n* Hypernatremia (Na ≥ 145)\n* Severe hyponatremia (Na ≤ 120)",true,"ALL","18 Years",{"count":72,"type":73},74,"ESTIMATED","INTERVENTIONAL",[76],"PHASE2","The goal of this study is to evaluate if hypertonic saline solution can prevent or attenuate acute kidney injury after heart transplantation in the early postoperative phase.",[79,80],"Heart Transplantation","Acute Kidney Injury","2026-04-29",{"date":83,"type":84},"2026-05-06","ACTUAL",{"date":86,"type":84},"2023-11-08",{"date":88,"type":73},"2027-03",{"name":59,"class":6},1]