[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637394":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":45,"responsibleParty":66,"collaborators":26,"id":69,"slug":26,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":26,"eligibilityCriteria":74,"healthyVolunteers":70,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":26,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":89,"overallStatus":48,"whyStopped":26,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Beni-Suef University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"L-Citrulline Plus Tamsulosin Placebo","EXPERIMENTAL","Participants will receive oral L-citrulline 750 mg twice daily plus a matched tamsulosin placebo once daily. Treatment will continue until documented stone passage or completion of 4 weeks of therapy, whichever occurs first. Standard supportive care will be provided as needed.",[13],"Drug: L-Citrulline",{"label":15,"type":16,"description":17,"interventionNames":18},"Tamsulosin Plus L-Citrulline Placebo","ACTIVE_COMPARATOR","Participants will receive oral tamsulosin 0.4 mg once daily plus a matched L-citrulline placebo twice daily. Treatment will continue until documented stone passage or completion of 4 weeks of therapy, whichever occurs first. Standard supportive care will be provided as needed.",[19],"Drug: Tamsulosin",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","L-Citrulline","Oral L-citrulline 750 mg twice daily will be administered until documented stone passage or completion of 4 weeks of therapy, whichever occurs first.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Tamsulosin","Oral tamsulosin 0.4 mg once daily will be administered until documented stone passage or completion of 4 weeks of therapy, whichever occurs first.",[15],[32],{"name":33,"affiliation":34,"role":35},"Hany F Badawy, MD","Faculty of Medicine, Beni-Suef University","PRINCIPAL_INVESTIGATOR",[37,41],{"name":33,"role":38,"phone":39,"phoneExt":26,"email":40},"CONTACT","+201149525028","Hanyfathy86@gmail.com",{"name":42,"role":38,"phone":43,"phoneExt":26,"email":44},"Ahmed Gmal, MD","+20 11 18206022","Drhanyfathy86@GMAIL.COM",[46],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Department of Urology- Beni-Suef University Hospitals","RECRUITING","Banī Suwayf","Beni Suweif Governorate","02456","Egypt",{"type":54,"coordinates":55},"Point",[56,57],31.09785,29.07441,{"lat":57,"lon":56},[60,61,65],{"name":33,"role":38,"phone":39,"phoneExt":26,"email":40},{"name":62,"role":38,"phone":63,"phoneExt":26,"email":64},"Mahmoud Abdallah, Md","+20 11 55361979","Mahmoud.abdalla@med.bsu.edu.eg",{"name":33,"role":35,"phone":26,"phoneExt":26,"email":26},{"type":35,"investigatorFullName":67,"investigatorTitle":68,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Hany Fathy Badawy, MD","Lecturer of Urology, Faculty of Medicine, Beni-Suef University","100637394",false,"NCT07617909","L-Citrulline Versus Tamsulosin for Medical Expulsive Therapy of Distal Ureteral Stones","L-Citrulline Versus Tamsulosin for Medical Expulsive Therapy of Distal Ureteral Stones: A Prospective Randomized Study","Inclusion Criteria:\n\n* Adults aged 18 to 60 years.\n* Single distal ureteral stone.\n* Stone size 5 to 10 mm.\n* Normal renal function.\n* Controlled pain.\n* Willingness to comply with follow-up for 4 weeks.\n* Written informed consent.\n\nExclusion Criteria:\n\n* Fever or active urinary tract infection.\n* Severe hydronephrosis.\n* Solitary kidney.\n* Pregnancy.\n* Previous ureteric surgery.\n* Multiple ureteral stones.\n* Indication for urgent surgical intervention.\n* Known hypersensitivity or contraindication to L-citrulline or tamsulosin.\n* Inability to complete follow-up.","ALL","18 Years","60 Years",{"count":79,"type":80},120,"ESTIMATED","INTERVENTIONAL",[83],"PHASE2","This study will compare L-citrulline and tamsulosin as medical expulsive therapy for adults with single distal ureteral stones.\n\nEligible participants with a single distal ureteral stone measuring 5 to 10 mm will be randomly assigned to receive either oral L-citrulline 750 mg twice daily or oral tamsulosin 0.4 mg once daily. Treatment will continue until documented stone passage or completion of 4 weeks of therapy, whichever occurs first.\n\nParticipants will be followed weekly for up to 4 weeks. The main outcome is stone expulsion within 4 weeks. The study will also assess time to stone expulsion, pain episodes, analgesic use, need for additional intervention, and adverse events.",[86,87,88],"Distal Ureteral Stone","Urolithiasis","Ureteral Calculi",[23,90,91,28],"Medical Expulsive Therapy","Ureteral Stone Passage","2026-05-25",{"date":94,"type":95},"2026-06-01","ACTUAL",{"date":97,"type":95},"2026-05-06",{"date":99,"type":80},"2026-11",{"name":5,"class":6},1]