Metformin IN Asthma for Overweight and Obese Individuals (MINA)
Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18+
SponsorJohns Hopkins University
About this trial
This is a randomized clinical trial of metformin among overweight or obese adults with not well-controlled asthma despite maintenance inhaler therapy.
Eligibility criteria
Qualifiers
Physician-diagnosed asthma on maintenance therapy
Not well-controlled asthma (ACT score <20, or at least one asthma exacerbation requiring corticosteroids in the prior 12 months)
Overweight or obesity: Body mass index ≥25kg/m2
Adult: Age ≥18
Disqualifiers
Currently pregnant, expect to become pregnant in the next 6 months or are currently breastfeeding
Major cardiovascular disease: heart failure, heart attack or stroke within the last 6 months
Other chronic lung disease, inclusive of chronic obstructive pulmonary disease, bronchiectasis, interstitial lung disease, pulmonary fibrosis
Active smoking or former smoker with ≥20 pack-year smoking history
Trial design
Treatments tested in this trial
- Metformin hydrochloride extended-release tablets
- Visually identical placebo Metformin hydrochloride extended-release tablets
Treatment groups
100 Participants
are divided into 2 treatment groupsLocations
2Johns Hopkins University21224, BaltimoreMaryland, United States
Baylor College of Medicine77030, HoustonTexas, United States
Sponsors and collaborators
Johns Hopkins University
Lead sponsor
Baylor College of Medicine
Collaborator
National Heart, Lung, and Blood Institute (NHLBI)
Collaborator
Temple University
Collaborator
Source ClinicalTrials.gov