About this trial
Adults who do not have major health, kidney, gastrointestinal disease will be randomized to receive oral mitoquinone/mitoquinol mesylate (Mito-MES) versus placebo to prevent the development and progression of COVID-19 after high-risk exposure to a person with confirmed SARS-CoV-2 infection.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
None
Disqualifiers
Women with variations in physiological functions due to hormones that may effect immune function and (transgender, pregnant, breastfeeding)
Specific significant clinical diseases [cardiovascular disease (such as coronary artery/vascular disease), heart disease (such as congestive heart failure, cardiomyopathy, atrial fibrillation), lung disease (such as chronic obstructive pulmonary disease, asthma, bronchiectasis, pulmonary fibrosis, pleural effusions), kidney disease (glomerular filtration rate or GFR less than 60 ml/min/1.73 m2), liver disease (such as cirrhosis, hepatitis), major immunosuppression (such as history of transplantation, uncontrolled HIV infection, cancer on active chemotherapy] based on history. Participants with well controlled HIV (CD4 count > 500 cells/mm^3 and HIV viral load < 50 copies/ml) and people with remote history of cancer not on active treatment will be allowed to participate.
History of known gastrointestinal disease (such as gastroparesis) that may predispose patients to nausea
History of auto-immune diseases
Trial design
Single group
Treatments tested in this trial
Mitoquinone/mitoquinol mesylate
DrugMitochondrial antioxidant
Placebo
Other interventionPlacebo pills
Treatment groups
Trial outcomes
Primary outcomes
SARS-CoV-2 infection
Confirmed SARS-CoV-2 infection based on a diagnostic test
Secondary outcomes
Safety of mito-MES
Side effects observed during use of mito-MES
Symptomatic SARS-CoV-2 infection
Development of symptomatic SARS-CoV-2 infection
Severity of symptoms of SARS-CoV-2 infection
Assessment of severity of symptoms of SARS-CoV-2 infection
Duration of symptoms of SARS-CoV-2 infection
Assessment of duration of symptoms of SARS-CoV-2 infection
Sponsors and contacts
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