NO AD: Use of Nitric Oxide (NO) Donors for the Prevention of Autonomic Dysreflexia (AD) During Bowel Care Following SCI

Trial statusNot yet recruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age19-80
SponsorSimon Fraser University

About this trial

This project aims to evaluate the safety and efficacy of using a short-acting drug to reduce the maximal blood pressure during dangerous blood pressure spikes that happen during bowel care in individuals with spinal cord injury. the investigators will monitor the physiological effects of this drug during at-home bowel care to best understand the drug's effects in typical use.

Eligibility criteria

Qualifiers

participants must have had a traumatic spinal cord injury at least one year ago

regular bowel care routine

can communicate in English

Disqualifiers

cauda equina or conus lesions

currently use ventilator

colostomy, or do not perform regular bowel care

skin breakdown (pressure sores)

Trial design

Treatments tested in this trial

  • Glyceryl Trinitrate Only Product in Oromucosal Dose Form
  • Placebo sublingual spray

Treatment groups

26 Participants
are divided into 2 treatment groups

Locations

This trial has no locations

Sponsors and collaborators

Simon Fraser University

Lead sponsor

University of British Columbia

Collaborator