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Clin. Hosp. of Emerg. and Intens. Care ( Site 0132)","Lviv","Lviv Oblast","79059",{"type":119,"coordinates":541},[542,543],24.02324,49.83826,{"lat":543,"lon":542},[546],{"name":126,"role":107,"phone":547,"phoneExt":70,"email":70},"380977453295",{"facility":549,"status":113,"city":550,"state":551,"zip":552,"country":500,"cosmosGeoPoint":553,"geoPoint":557,"contacts":558},"ME RIVNE REGIONAL ANTITUMOR CENTER ( Site 0460)","Rivne","Rivne Oblast","33010",{"type":119,"coordinates":554},[555,556],26.23695,50.62036,{"lat":556,"lon":555},[559],{"name":126,"role":107,"phone":560,"phoneExt":70,"email":70},"380503802915",{"facility":562,"status":113,"city":563,"state":564,"zip":565,"country":500,"cosmosGeoPoint":566,"geoPoint":570,"contacts":571},"Communal Noncommercial Enterprise \"Podillia Regional Oncology Center Of Vinnytsia Regional Council\" ( Site 0135)","Vinnytsia","Vinnytsia Oblast","21029",{"type":119,"coordinates":567},[568,569],28.46871,49.2322,{"lat":569,"lon":568},[572],{"name":126,"role":107,"phone":573,"phoneExt":70,"email":70},"0988936318",{"facility":575,"status":113,"city":576,"state":70,"zip":577,"country":500,"cosmosGeoPoint":578,"geoPoint":582,"contacts":583},"Shalimov Institute of Surgery and Transplantation ( Site 0138)","Kyiv","03126",{"type":119,"coordinates":579},[580,581],30.5238,50.45466,{"lat":581,"lon":580},[584],{"name":126,"role":107,"phone":585,"phoneExt":70,"email":70},"093 33 33 911",{"type":587,"investigatorFullName":70,"investigatorTitle":70,"investigatorAffiliation":70,"oldNameTitle":70,"oldOrganization":70},"SPONSOR","100576716",false,"NCT06788912","Pembrolizumab (MK-3475) Plus Investigational Agents in Resectable Non-small Cell Lung Cancer (NSCLC) (MK-3475-01E\u002FKEYMAKER-U01)","KEYMAKER-U01 Substudy 01E: A Phase 2 Umbrella Study With Rolling Arms of Investigational Agents With or Without Chemotherapy in Combination With Pembrolizumab in Treatment of Participants With Newly Diagnosed Resectable Stages II-IIIB (N2) Non-small Cell Lung Cancer (NSCLC)","The main inclusion and exclusion criteria include but are not limited to the following:\n\nInclusion Criteria:\n\n* Has previously untreated and pathologically confirmed resectable Stage II, IIIA, or IIIB (N2) non-small cell lung cancer (NSCLC)\n* Able to undergo protocol therapy, including necessary surgery\n* Confirmation that epidermal growth factor receptor (EGFR) -directed therapy is not indicated as primary therapy\n* Has an Eastern Cooperative Oncology Group (ECOG) performance status of either 0 or 1 as assessed within 10 days before initiation of study intervention.\n* Is able to provide archival or newly obtained core\u002Fexcisional biopsy of the primary lung tumor or lymph node metastasis.\n\nExclusion Criteria:\n\n* Has one of the following tumor locations\u002Ftypes: NSCLC involving the superior sulcus, large-cell neuro-endocrine cancer, mixed tumors containing small cell and non-small cell elements, or sarcomatoid tumor.\n* Has Grade ≥2 peripheral neuropathy.\n* Has history of documented severe dry eye syndrome, severe Meibomian gland disease and\u002For blepharitis, or severe corneal disease that prevents\u002Fdelays corneal healing.\n* Has active inflammatory bowel disease requiring immunosuppressive medication or previous history of inflammatory bowel disease (eg, Crohn's disease, ulcerative colitis, or chronic diarrhea).\n* Has uncontrolled, significant cardiovascular disease or cerebrovascular disease.\n* Received a live or live-attenuated vaccine within 30 days before the first dose of study intervention\n* Received prior radiotherapy within 2 weeks of start of study intervention, or radiation related toxicities, requiring corticosteroids.\n* Diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy (in dosing exceeding 10 mg daily of prednisone equivalent) or any other form of immunosuppressive therapy within 7 days prior to the first dose of study intervention.\n* Known additional malignancy that is progressing or has required active treatment within the past 5 years.\n* Severe hypersensitivity (≥Grade 3) to pembrolizumab and\u002For any of its excipients.\n* Active autoimmune disease that has required systemic treatment in the past 2 years. Replacement therapy (e.g. thyroxine, insulin, or physiologic corticosteroid) is allowed.\n* History of (noninfectious) pneumonitis\u002Finterstitial lung disease that required steroids or has current pneumonitis\u002Finterstitial lung disease.\n* Active infection requiring systemic therapy.\n* Hepatitis B (defined as hepatitis B surface antigen \\[HBsAg\\] reactive) or Hepatitis C virus (defined as detectable hepatitis C virus (HCV) ribonucleic acid (RNA) \\[qualitative\\]) infection.\n* Known history of human immunodeficiency virus (HIV) infection.\n* History of allogeneic tissue\u002Fsolid organ transplant.","ALL","18 Years",{"count":597,"type":598},60,"ESTIMATED","INTERVENTIONAL",[601],"PHASE2","The main goals are after treatment given before surgery, to measure the number of people who have no signs of cancer cells in tumors and lymph nodes removed during surgery; and to learn about whether the cancer gets smaller or goes away by measuring the number of people with a certain number of living cancer cells in the tumor removed during surgery.",[604],"Lung Neoplasm Malignant",[606,607,608],"Programmed Cell Death-1 (PD1, PD-1)","Programmed Cell Death 1 Ligand 1(PDL1, PD-L1)","Programmed Cell Death 1 Ligand 2 (PDL2, PD-L2)","2026-06-25",{"date":611,"type":612},"2026-06-26","ACTUAL",{"date":614,"type":612},"2025-03-20",{"date":616,"type":598},"2032-02-06",{"name":5,"class":6},38]