[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100525590":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":33,"centralContacts":46,"locations":57,"responsibleParty":93,"collaborators":95,"id":101,"slug":73,"hasResults":102,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":106,"eligibilityCriteria":107,"healthyVolunteers":102,"sex":108,"minAge":109,"maxAge":73,"enrollmentInfo":110,"targetDuration":73,"studyType":113,"phases":114,"briefSummary":116,"conditions":117,"keywords":73,"overallStatus":60,"whyStopped":73,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":130},{"fullName":5,"class":6},"University Health Network, Toronto","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention","EXPERIMENTAL","Preoperative Vitamin C capsules",[13],"Drug: Vitamin C",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo","PLACEBO_COMPARATOR","Preoperative placebo capsules",[19],"Drug: Placebo",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Vitamin C","Drug: Patients in the intervention group will receive 2g Vitamin C orally within 4 hours of the start of the surgery followed by 500 mg of Vitamin C to be taken orally twice a day from post-op day1 to day 56.",[9],[27],"Ascorbic Acid",{"type":22,"name":15,"description":29,"armGroupLabels":30,"otherNames":31},"Drug: Patients in the placebo group will receive identical placebo capsules taken orally within 4 hours of the start of the surgery followed by placebo capsules taken orally twice a day from post-op day 1 to day 56.",[15],[32],"Lactose (Monohydrate)",[34,38,41,43],{"name":35,"affiliation":36,"role":37},"James Khan, MD","University Health Network; Department of Anesthesia and Pain Medicine","PRINCIPAL_INVESTIGATOR",{"name":39,"affiliation":40,"role":37},"Raman Mundi, MD","Holland Orthopedic and Arthritic Centre",{"name":42,"affiliation":40,"role":37},"Harman Chaudhry, MD",{"name":44,"affiliation":45,"role":37},"Jesse Wolfstadt, MD","Mount Sinai Hospital; Department of Surgery",[47,52],{"name":35,"role":48,"phone":49,"phoneExt":50,"email":51},"CONTACT","416-340-4800","3243","James.Khan@medportal.ca",{"name":53,"role":48,"phone":54,"phoneExt":55,"email":56},"Nour Ayach","(416) 340 4800","4221","Nour.Ayach@uhn.ca",[58,75,83],{"facility":59,"status":60,"city":61,"state":62,"zip":63,"country":64,"cosmosGeoPoint":65,"geoPoint":70,"contacts":71},"Sunnybrook - Holland Centre","RECRUITING","Toronto","Ontario","M4Y 1H1","Canada",{"type":66,"coordinates":67},"Point",[68,69],-79.39864,43.70643,{"lat":69,"lon":68},[72],{"name":39,"role":48,"phone":73,"phoneExt":73,"email":74},null,"Raman.Mundi@medportal.ca",{"facility":76,"status":60,"city":61,"state":62,"zip":77,"country":64,"cosmosGeoPoint":78,"geoPoint":80,"contacts":81},"Mount Sinai Hospital","M5G 1X5",{"type":66,"coordinates":79},[68,69],{"lat":69,"lon":68},[82],{"name":35,"role":48,"phone":73,"phoneExt":73,"email":51},{"facility":84,"status":60,"city":61,"state":62,"zip":85,"country":64,"cosmosGeoPoint":86,"geoPoint":88,"contacts":89},"Toronto Western Hospital","M5T 2S8",{"type":66,"coordinates":87},[68,69],{"lat":69,"lon":68},[90],{"name":91,"role":48,"phone":73,"phoneExt":73,"email":92},"Anuj Bhatia, MD","Anuj.Bhatia@uhn.ca",{"type":94,"investigatorFullName":73,"investigatorTitle":73,"investigatorAffiliation":73,"oldNameTitle":73,"oldOrganization":73},"SPONSOR",[96,99],{"name":97,"class":98},"Canadian Institutes of Health Research (CIHR)","OTHER_GOV",{"name":100,"class":6},"The Arthritis Society, Canada","100525590",false,"NCT06123715","Perioperative Vitamin C to Reduce Persistent Pain After Total Knee Arthroplasty","PeRiOperative VItamin C to Reduce perSistent paIn After tOtal kNee Arthroplasty (PROVISION): a Pilot Multicentre Randomized Controlled Trial","PROVISION","Inclusion Criteria:\n\n* Patients \\>18 years old\n* Undergoing a unilateral or bilateral primary total knee arthroplasty for advanced osteoarthritis of the knee\n\nExclusion Criteria:\n\n* TKA for infection (septic joint), fracture, ankylosing spondylitis, lupus, or psoriatic arthritis\n* History of kidney stones, acute or chronic renal failure, hemochromatosis, or glucose-6-phosphate deficiency\n* Unlikely to comply with follow-up (e.g., no fixed address, plans to move out of town)\n* Language difficulties that would impede valid completion of questionnaires\n* Planned staged bilateral TKA\n* Treating surgeon deems patient inappropriate for inclusion in trial\n* Any allergy or sensitivity to milk\n* Pregnant or planning to become pregnant during the study","ALL","18 Years",{"count":111,"type":112},400,"ESTIMATED","INTERVENTIONAL",[115],"PHASE2","Phase II Multicentre, pilot, parallel-group, blinded, 1:1 randomized controlled trial to determine the feasibility of conducting a larger definitive trail of using vitamin C to reduce persistent pain in patients undergoing total knee arthroplasty surgery.",[118,119,120],"Chronic Pain","Knee Pain Chronic","Post Operative Pain","2026-06-19",{"date":123,"type":124},"2026-06-23","ACTUAL",{"date":126,"type":124},"2024-04-16",{"date":128,"type":112},"2027-12-31",{"name":5,"class":6},3]