Phase II Clinical Trial of PD-L1 in Combination With Vinorelbine + Cyclophosphamide + Capecitabine (VEX) Metronomic Chemotherapy With or Without Radiotherapy for Advanced Triple-negative Breast Cancer.

Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18+
SponsorCancer Institute and Hospital, Chinese Academy of Medical Sciences

About this trial

Phase II clinical trial of PD-L1 in combination with vinorelbine + cyclophosphamide + capecitabine (VEX) metronomic chemotherapy with or without radiotherapy for advanced triple-negative breast cancer.

Eligibility criteria

Qualifiers

Male or female who is 18 years of age or older on the day of signing the informed consent form.

Subjects with metastatic triple-negative breast cancer, with clear clinical data records; specific reference to the "American Society of Clinical Oncology - College of American Pathologists (ASCO/CAP) guidelines."

Have received less than or equal to 1 line of chemotherapy for metastatic breast cancer;

Have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 as assessed within 10 days before the start of study treatment;

Disqualifiers

None

Trial design

Treatments tested in this trial

  • Adebrelimab + VEX metronomic chemotherapy + radiotherapy
  • Adebrelimab + VEX metronomic chemotherapy

Treatment groups

150 Participants
are divided into 2 treatment groups

Locations

2
Cancer Hospital, Chinese Academy of Medical Sciences100021, BeijingBeijing Municipality, China
Cancer Hospital, Chinese Academy of Medical Sciences100021, BeijingBeijing Municipality, China

Sponsors and collaborators

Cancer Institute and Hospital, Chinese Academy of Medical Sciences

Lead sponsor