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42",{"type":58,"coordinates":164},[165,166],22.93493,40.64072,{"lat":166,"lon":165},[169],{"name":86,"role":45,"phone":170,"phoneExt":47,"email":47},"306937442644",{"facility":172,"status":75,"city":173,"state":47,"zip":174,"country":175,"cosmosGeoPoint":176,"geoPoint":180,"contacts":181},"Rambam Medical Center ( Site 1402)","Haifa","3109601","Israel",{"type":58,"coordinates":177},[178,179],34.99928,32.81303,{"lat":179,"lon":178},[182],{"name":86,"role":45,"phone":183,"phoneExt":47,"email":47},"+97247774512",{"facility":185,"status":52,"city":186,"state":47,"zip":187,"country":175,"cosmosGeoPoint":188,"geoPoint":192,"contacts":47},"Hadassah Ein Karem Hebrew University Medical Center ( Site 1401)","Jerusalem","9112001",{"type":58,"coordinates":189},[190,191],35.21633,31.76904,{"lat":191,"lon":190},{"facility":194,"status":75,"city":195,"state":47,"zip":196,"country":175,"cosmosGeoPoint":197,"geoPoint":201,"contacts":202},"Sheba Medical Center ( Site 1404)","Ramat Gan","5265601",{"type":58,"coordinates":198},[199,200],34.81065,32.08227,{"lat":200,"lon":199},[203],{"name":86,"role":45,"phone":204,"phoneExt":47,"email":47},"+97235305046",{"facility":206,"status":75,"city":207,"state":47,"zip":208,"country":175,"cosmosGeoPoint":209,"geoPoint":213,"contacts":214},"Sourasky Medical Center ( Site 1403)","Tel Aviv","6423906",{"type":58,"coordinates":210},[211,212],34.78057,32.08088,{"lat":212,"lon":211},[215],{"name":86,"role":45,"phone":216,"phoneExt":47,"email":47},"+97236974521",{"facility":218,"status":75,"city":219,"state":219,"zip":220,"country":221,"cosmosGeoPoint":222,"geoPoint":226,"contacts":227},"Instituto Nacional de Pediatria-Unidad de Apoyo a la Investigación Clínica ( Site 2200)","Mexico 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8183486173",{"facility":253,"status":75,"city":254,"state":47,"zip":255,"country":256,"cosmosGeoPoint":257,"geoPoint":261,"contacts":262},"Instituto Nacional de Enfermedades Neoplasicas ( Site 1601)","Lima","15038","Peru",{"type":58,"coordinates":258},[259,260],-77.02824,-12.04318,{"lat":260,"lon":259},[263],{"name":86,"role":45,"phone":264,"phoneExt":47,"email":47},"+5112016500",{"facility":266,"status":75,"city":267,"state":268,"zip":269,"country":270,"cosmosGeoPoint":271,"geoPoint":275,"contacts":276},"Uniwersytecki Szpital Kliniczny im. 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Petersburg","Sankt-Peterburg","194291","Russia",{"type":58,"coordinates":296},[297,298],30.31413,59.93863,{"lat":298,"lon":297},{"facility":301,"status":52,"city":291,"state":292,"zip":302,"country":294,"cosmosGeoPoint":303,"geoPoint":305,"contacts":47},"Pavlov State Medical University ( Site 1801)","197022",{"type":58,"coordinates":304},[297,298],{"lat":298,"lon":297},{"facility":307,"status":52,"city":308,"state":309,"zip":310,"country":294,"cosmosGeoPoint":311,"geoPoint":315,"contacts":47},"Regional Children Clinical Hospital 1 ( Site 1802)","Yekaterinburg","Sverdlovsk Oblast","620149",{"type":58,"coordinates":312},[313,314],60.61529,56.85733,{"lat":314,"lon":313},{"facility":317,"status":75,"city":318,"state":47,"zip":319,"country":320,"cosmosGeoPoint":321,"geoPoint":325,"contacts":326},"Seoul National University Hospital-Pediatrics ( Site 2600)","Seoul","03080","South Korea",{"type":58,"coordinates":322},[323,324],126.9784,37.566,{"lat":324,"lon":323},[327],{"name":86,"role":45,"phone":328,"phoneExt":47,"email":47},"+82220723452",{"facility":330,"status":75,"city":331,"state":332,"zip":333,"country":334,"cosmosGeoPoint":335,"geoPoint":339,"contacts":340},"Ivano-Frankivsk Regional Pediatric Clinical Hospital ( Site 1911)","Ivano-Frankivsk","Ivano-Frankivsk Oblast","76014","Ukraine",{"type":58,"coordinates":336},[337,338],24.71248,48.92312,{"lat":338,"lon":337},[341],{"name":86,"role":45,"phone":342,"phoneExt":47,"email":47},"+380971550299",{"facility":344,"status":75,"city":345,"state":346,"zip":347,"country":334,"cosmosGeoPoint":47,"geoPoint":47,"contacts":348},"NATIONAL CHILDREN'S SPECIALIZED HOSPITAL \"OKHMATDYT\" OF THE -Intensive Care Unit ( Site 1912)","Kiev","Kyiv Oblast","01135",[349],{"name":86,"role":45,"phone":350,"phoneExt":47,"email":47},"+380685949474",{"type":352,"investigatorFullName":47,"investigatorTitle":47,"investigatorAffiliation":47,"oldNameTitle":47,"oldOrganization":47},"SPONSOR","100413549",false,"NCT04665037","Posaconazole (MK-5592) Intravenous and Oral in Children (\u003C2 Years) With Invasive Fungal Infection (MK-5592-127)","A Phase 2, Open-Label, Single-Arm, Sequential-Panel Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Posaconazole (POS, MK-5592) Intravenous and Powder for Oral Suspension Formulations in Pediatric Participants From Birth to Less Than 2 Years of Age With Possible, Probable, or Proven Invasive Fungal Infection","Inclusion Criteria:\n\n* Panel A: is undergoing treatment for possible, probable, or proven IFI known or suspected to be cause by fungal pathogens against which POS has demonstrated activity (which can include candidiasis)\n* Panel B: has an investigator-assessed diagnosis of possible, probable, or proven IFI known or suspected to be cause by fungal pathogens against which POS has demonstrated activity (and cannot include candidiasis)\n* Has a central line (eg, central venous catheter, peripherally-inserted central catheter) in place or planned to be in place before beginning IV study intervention.\n* Has a body weight of ≥500 g\n* The participant (or legally acceptable representative) has provided documented informed consent for the study.\n\nExclusion Criteria\n\n* Has received POS within 30 days before Day 1\n* Has cystic fibrosis, pulmonary sarcoidosis, aspergilloma, or allergic bronchopulmonary aspergillosis\n* Has a known hereditary problem of galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption\n* Has known or suspected active COVID-19 infection\n* Has a known hypersensitivity or other serious adverse reaction to any azole antifungal therapy, or to any other ingredient of the study intervention used\n* Has any known history of torsade de pointes, unstable cardiac arrhythmia or proarrhythmic conditions, a history of recent myocardial infarction, congenital or acquired QT interval (QT) prolongation, or cardiomyopathy in the context of cardiac failure within 90 days of first dose of study intervention\n* Has received any listed prohibited medications within the specified timeframes before the start of study intervention\n* Has a known hereditary problem of galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption (Part B)\n* Has suspected\u002Fproven invasive candidiasis (Part B)\n* Has enrolled previously in the current study and been discontinued\n* Has QTc prolongation at screening \\>500 msec\n* Has significant liver dysfunction\n* Is hemodynamically unstable, exhibits hemodynamic compromise, or is not expected to survive at least 5 days","ALL","1 Day","2 Years",{"count":363,"type":364},40,"ESTIMATED","INTERVENTIONAL",[367],"PHASE2","This study aims to estimate the pharmacokinetics (PK) of posaconazole (POS, MK-5592) intravenous (IV) and powder for oral suspension (PFS) formulations in pediatric participants \\\u003C2 years of age with invasive fungal infection (IFI).",[370],"Invasive Fungal Infection","2025-09-17",{"date":373,"type":374},"2025-09-18","ACTUAL",{"date":376,"type":374},"2022-02-22",{"date":378,"type":364},"2026-12-31",{"name":5,"class":6},26]