About this trial

This study will collect data that measures the effects of a psychedelic intervention on patients struggling with alcohol use disorder (AUD). The study design will be a double blind, randomized, active-comparator trial with two study arms. Subjects randomized to Arm 1 (n=40) will receive individual psychotherapy sessions plus a 30 mg dose of psilocybin. Arm 2 subjects (n=40) will receive individual psychotherapy sessions and a 0.75 mg/kg dose of ketamine.

Eligibility criteria

Qualifiers

Weight between 50kg and 150kg

No known allergies to rescue medication

For people capable of becoming pregnant, not pregnant and using contraception

Not currently breastfeeding

Disqualifiers

None

Trial design

Treatments tested in this trial

  • Psilocybin
  • Ketamine

Treatment groups

80 Participants
are divided into 2 treatment groups

Locations

1
University of Iowa Health Care52240, Iowa CityIowa, United States

Sponsors and collaborators

University of Iowa

Lead sponsor