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in Combination With Different Treatment Regimens in Patients With Gynecological Cancers","An Open-label, Global, Multi-Arm Study to Evaluate the Efficacy and Safety of Relacorilant in Combination With Different Treatment Regimens in Patients With Gynecological Cancers (BELLA)","Inclusion Criteria:\n\nArms A and B\n\n* Histologic diagnosis of epithelial ovarian, primary peritoneal, or fallopian-tube carcinoma\n* Arm A Only: Platinum-resistant disease\n* Arm B Only: Platinum-sensitive disease who had progression while receiving treatment with a poly(ADP-ribose) polymerase (PARP) inhibitor\n* Life expectancy of ≥3 months\n* Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1\n* Able to swallow and retain oral medication\n* 1 to 3 lines of prior systemic anticancer therapy\n* Adequate organ function\n* Negative pregnancy test for patients of childbearing potential\n\nArm C\n\n* Stage III or IV, recurrent, or metastatic endometrial cancer\n* Life expectancy of ≥3 months\n* ECOG performance status of 0 or 1\n* Able to swallow and retain oral medication\n* Prior treatment with a platinum agent and an approved anti-Programmed Cell Death Ligand 1 (PD\\[L\\]1) antibody\n* 1 to 2 lines of prior systemic anticancer therapy for endometrial cancer\n* Must consent to provide an available formalin-fixed paraffin-embedded (FFPE) tumor tissue block or recently cut sections\n* Adequate organ function\n* Negative pregnancy test for patients of childbearing potential\n\nExclusion Criteria:\n\nArm A and B\n\n* Arm A Only: Has progressed while receiving weekly paclitaxel or nab-paclitaxel\n* Prior enrollment in a clinical trial of relacorilant\n* Prior anticancer therapy related toxicities not resolved to grade ≤1\n* Any surgery within 4 weeks prior to enrollment\n* Wide-field radiation to more than 25% of marrow-bearing areas\n* Medical conditions requiring chronic or frequent treatment with corticosteroids\n* Concurrent treatment with mifepristone or other glucocorticoid receptor modulators\n* Peripheral neuropathy from any cause \\>Grade 1\n* Hypertension: ≥150 mm Hg systolic or ≥100 mm Hg diastolic\n* Uncontrolled condition(s) which, may confound the results of the trial or interfere with the patient's safety or participation\n* Bowel obstruction ≤12 weeks prior to study entry\n* Ascites or pleural effusions requiring therapeutic paracentesis\n* Untreated or symptomatic central nervous system metastases\n* History of other malignancy within 3 years prior to enrollment\n* Has received a live vaccine within 30 days prior to the study start date\n\nArm C\n\n* Has progressed while receiving weekly paclitaxel or nab-paclitaxel\n* Prior enrollment in a clinical trial of relacorilant\n* Prior anticancer therapy related toxicities not resolved to grade ≤1\n* Any surgery within 4 weeks prior to enrollment\n* Wide-field radiation to more than 25% of marrow-bearing areas\n* Medical conditions requiring chronic or frequent treatment with corticosteroids\n* Concurrent treatment with mifepristone or other glucocorticoid receptor modulators\n* Peripheral neuropathy from any cause \\>Grade 1\n* Uncontrolled condition(s) which, may confound the results of the trial or interfere with the patient's safety or participation\n* Bowel obstruction ≤12 weeks prior to study entry\n* Ascites or pleural effusions requiring therapeutic paracentesis\n* History of other malignancy within 3 years prior to enrollment\n* Has received a live vaccine within 30 days prior to the study start date\n* Patients with central nervous system metastases are not eligible, unless they have completed local therapy and have discontinued the use of corticosteroids for this indication for at least 4 weeks before starting treatment in this study.","FEMALE","18 Years",{"count":512,"type":513},270,"ESTIMATED","INTERVENTIONAL",[516],"PHASE2","This is a Phase 2, open-label, global, multi-arm study to evaluate efficacy and safety of relacorilant in combination with other treatments in patients with gynecological cancers.",[519,520,521,522],"Ovarian Cancer","Fallopian Tube Cancer","Peritoneal Neoplasms","Endometrial Cancer",[524,525,526,527,528,529,530,521,531,532,533,534,535,536,537,538,539,540,541,542],"Genital Neoplasms, Female","Neoplasms by Site","Fallopian Tube Diseases","Ovarian Diseases","Neoplasms","Fallopian Tube Neoplasms","Ovarian Neoplasms","Paclitaxel","Albumin-Bound Paclitaxel","Ovarian","Peritoneal or Advanced Fallopian Tube Cancer","High Grade","Platinum Resistant","Relacorilant","Bella","Nab-paclitaxel","Bevacizumab","Endometrial Neoplasm","Endometrial","2026-04-09",{"date":545,"type":546},"2026-04-14","ACTUAL",{"date":548,"type":546},"2025-04-11",{"date":550,"type":513},"2026-12",{"name":5,"class":6},49]