To find out if adding medication can help treat or prevent lymphedema and/or fibrosis related to radiation therapy, in survivors of head and neck cancer. Researchers will compare these drugs to find the most effective therapy for preventing or limiting these side effects.
Prior history of head and neck cancer with no active disease.
Treated previously with radiotherapy with prescribed dose (greater or equal to 30Gy) to unilateral or bilateral neck(s)
Detectable CTC-AE G2+ lymphedema/fibrosis at >6 months post-radiotherapy.
No active liver disease (Child-Pugh class B-C), cirrhosis, nor active alcoholism, nor history of ulcers.
Active liver disease (Child-Pugh class B-C), cirrhosis, nor active alcoholism.
History of myopathy/rhabdomyolysis.
History of acute myocardial infarction or severe coronary disease.
Pregnant/post-menopausal, or male.
M.D. Anderson Cancer Center
Lead sponsor