Participants will receive Transcranial Magnetic Stimulation (TMS) at a random location in the left prefrontal cortex, excluding sites that are potentially unsafe. Extensive behavioral testing will be conducted to determine which behaviors are modulated by stimulating which circuits.
Age 18-65
English proficiency sufficient for informed consent, questionnaires/tasks, and treatment
Primary diagnosis of one of the following: major depressive disorder (MDD), obsessive-compulsive disorder (OCD), generalized anxiety disorder (GAD), or schizophrenia (determined by focal assessment using the Structured Clinical Interview for DSM-5)
≥20 on the Beck Depression Inventory for patients with MDD
Active pregnancy as determined by a urine pregnancy test
Cluster B personality disorders (antisocial personality disorder, borderline personality disorder, histrionic personality disorder, narcissistic personality disorder)
PTSD with active, clinically significant symptoms, as determined by clinician
Diagnosis of Schizoaffective Disorder, Bipolar Type
Brigham and Women's Hospital
Lead sponsor
Harvard Medical School (HMS and HSDM)
Sponsor institution
National Institute of Mental Health (NIMH)
Collaborator