Stereotactic Radiosurgery Versus Radiofrequency Ablation for Primary Liver Cancer

Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18-75
SponsorTianjin Medical University Cancer Institute and Hospital

About this trial

A phase II clinical trial of stereotactic radiosurgery versus radiofrequency ablation in the treatment of inoperable primary liver cancer in specific sites

Eligibility criteria

Qualifiers

Prior to implementing any trial-related procedures, written informed consent must be signed;

Age ≥ 18 years and ≤ 75 years;

Child-Pugh score ≤ 7;KPS score ≥ 70;

The patient must be clearly diagnosed with hepatocellular carcinoma, usually confirmed through imaging (CT, MRI) or histological examination (biopsy);

Disqualifiers

Possible surgical intervention;

Presence of other serious comorbidities, such as uncontrolled cardiovascular diseases, pulmonary diseases, or dysfunction of other organs, where the overall health status is poor and may result in treatment intolerance;

Severe liver dysfunction exceeding the specific criteria defined in the trial;

Other malignancies diagnosed within 5 years prior to the first treatment or at the time of diagnosis of hepatocellular carcinoma;

Trial design

Treatments tested in this trial

  • Stereotactic Body Radiation Therapy (SBRT)
  • Radiofrequency ablation therapy

Treatment groups

130 Participants
are divided into 2 treatment groups

Locations

1
Department of Hepatobiliary Oncology and Radiation Oncology,Tianjin Medical University Cancer Institute & Hospital,Key Laboratory of Cancer Prevention and Therapy,National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer300060, Tianjin China

Sponsors and collaborators

Tianjin Medical University Cancer Institute and Hospital

Lead sponsor