[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100489857":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":30,"locations":40,"responsibleParty":600,"collaborators":29,"id":602,"slug":29,"hasResults":603,"nctId":604,"briefTitle":605,"officialTitle":606,"acronym":29,"eligibilityCriteria":607,"healthyVolunteers":603,"sex":608,"minAge":609,"maxAge":29,"enrollmentInfo":610,"targetDuration":29,"studyType":613,"phases":614,"briefSummary":617,"conditions":618,"keywords":626,"overallStatus":56,"whyStopped":29,"lastUpdateSubmitDate":645,"lastUpdatePostDateStruct":646,"startDateStruct":649,"completionDateStruct":651,"leadSponsor":653,"locationsCount":654},{"fullName":5,"class":6},"Olatec Therapeutics LLC","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Dapansutrile","EXPERIMENTAL","An initial loading dose of 2000 mg dapansutrile on Day 1 followed by a maintenance regimen of 1000 mg dapansutrile twice daily starting 12 hours later through the second dose on Day 7, inclusive.",[13],"Drug: Dapansutrile",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo Tablet","PLACEBO_COMPARATOR","An initial loading dose of matching placebo (to mimic dapansutrile dosing) on Day 1 followed by a maintenance regimen of matching placebo twice daily starting 12 hours later through the second dose on Day 7, inclusive.",[19],"Other: Placebo Tablet",[21,26],{"type":22,"name":9,"description":11,"armGroupLabels":23,"otherNames":24},"DRUG",[9],[25],"OLT1177",{"type":27,"name":15,"description":17,"armGroupLabels":28,"otherNames":29},"OTHER",[15],null,[31,37],{"name":32,"role":33,"phone":34,"phoneExt":35,"email":36},"Philip Piscitelli","CONTACT","+1 833-652-8321","115","phil.piscitelli@olatec.com",{"name":38,"role":33,"phone":29,"phoneExt":29,"email":39},"Clinical Operations","clinops@olatec.com",[41,54,73,87,97,113,129,146,162,178,195,212,228,238,254,265,275,292,301,307,317,334,351,368,378,394,409,422,432,442,455,471,487,503,516,532,545,555,571,587],{"facility":42,"status":43,"city":44,"state":45,"zip":46,"country":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":29},"University of Alabama at Birmingham","WITHDRAWN","Birmingham","Alabama","35294","United States",{"type":49,"coordinates":50},"Point",[51,52],-86.80249,33.52066,{"lat":52,"lon":51},{"facility":55,"status":56,"city":57,"state":58,"zip":59,"country":47,"cosmosGeoPoint":60,"geoPoint":64,"contacts":65},"Arizona Arthritis & Rheumatology Associates - Glendale","RECRUITING","Glendale","Arizona","85306",{"type":49,"coordinates":61},[62,63],-112.18599,33.53865,{"lat":63,"lon":62},[66,70],{"name":67,"role":33,"phone":68,"phoneExt":29,"email":69},"Rebecca Martinez","480-350-7655","rebecca.martinez@azarthritis.com",{"name":71,"role":72,"phone":29,"phoneExt":29,"email":29},"Mona Amin, MD","PRINCIPAL_INVESTIGATOR",{"facility":74,"status":56,"city":75,"state":58,"zip":76,"country":47,"cosmosGeoPoint":77,"geoPoint":81,"contacts":82},"Arizona Arthritis & Rheumatology Associates (AARA), P.C. - Mesa","Mesa","85210",{"type":49,"coordinates":78},[79,80],-111.82264,33.42227,{"lat":80,"lon":79},[83,85],{"name":84,"role":33,"phone":68,"phoneExt":29,"email":69},"Rebecca 480-350-7655",{"name":86,"role":72,"phone":29,"phoneExt":29,"email":29},"Swati Bharadwaj, MD",{"facility":88,"status":43,"city":89,"state":90,"zip":91,"country":47,"cosmosGeoPoint":92,"geoPoint":96,"contacts":29},"American Institute of Research","Los Angeles","California","90017",{"type":49,"coordinates":93},[94,95],-118.24368,34.05223,{"lat":95,"lon":94},{"facility":98,"status":56,"city":99,"state":90,"zip":100,"country":47,"cosmosGeoPoint":101,"geoPoint":105,"contacts":106},"TriWest Research Associates","San Diego","92108",{"type":49,"coordinates":102},[103,104],-117.16472,32.71571,{"lat":104,"lon":103},[107,111],{"name":108,"role":33,"phone":109,"phoneExt":29,"email":110},"Lennette Fontelar","619-334-4735","lfontelar@triwestresearch.com",{"name":112,"role":72,"phone":29,"phoneExt":29,"email":29},"Arthur Ray Mabaquiao, MD",{"facility":114,"status":56,"city":115,"state":90,"zip":116,"country":47,"cosmosGeoPoint":117,"geoPoint":121,"contacts":122},"Valiance Clinical Research - Tarzana","Tarzana","91356",{"type":49,"coordinates":118},[119,120],-118.55397,34.17334,{"lat":120,"lon":119},[123,127],{"name":124,"role":33,"phone":125,"phoneExt":29,"email":126},"Gail Ma","818-938-9167","g.ma@valianceclinicalresearch.com",{"name":128,"role":72,"phone":29,"phoneExt":29,"email":29},"Richard Park, MD",{"facility":130,"status":56,"city":131,"state":132,"zip":133,"country":47,"cosmosGeoPoint":134,"geoPoint":138,"contacts":139},"Hillcrest Medical Research","DeLand","Florida","32720",{"type":49,"coordinates":135},[136,137],-81.30312,29.02832,{"lat":137,"lon":136},[140,144],{"name":141,"role":33,"phone":142,"phoneExt":29,"email":143},"Larry Moulder","321-999-7616","lmoulder@hillcrestmedicalresearch.com",{"name":145,"role":72,"phone":29,"phoneExt":29,"email":29},"John Hill, MD",{"facility":147,"status":56,"city":148,"state":132,"zip":149,"country":47,"cosmosGeoPoint":150,"geoPoint":154,"contacts":155},"SIMEDHealth","Gainesville","32607,",{"type":49,"coordinates":151},[152,153],-82.32483,29.65163,{"lat":153,"lon":152},[156,160],{"name":157,"role":33,"phone":158,"phoneExt":29,"email":159},"Brandy Donahue-Quails","352-333-3885","Bdonahue-quails@simedresearch.com",{"name":161,"role":72,"phone":29,"phoneExt":29,"email":29},"Timothy H Elder, MD",{"facility":163,"status":56,"city":164,"state":132,"zip":165,"country":47,"cosmosGeoPoint":166,"geoPoint":170,"contacts":171},"University of Florida Health Jacksonville","Jacksonville","32256",{"type":49,"coordinates":167},[168,169],-81.65565,30.33218,{"lat":169,"lon":168},[172,176],{"name":173,"role":33,"phone":174,"phoneExt":29,"email":175},"Shannon Lloyd","904-633-0071","shannon.lloyd@ufhealth.org",{"name":177,"role":72,"phone":29,"phoneExt":29,"email":29},"Gurjit Kaeley, MD",{"facility":179,"status":56,"city":180,"state":132,"zip":181,"country":47,"cosmosGeoPoint":182,"geoPoint":186,"contacts":187},"Well Pharma Medical Research","Miami","33173",{"type":49,"coordinates":183},[184,185],-80.19366,25.77427,{"lat":185,"lon":184},[188,193],{"name":189,"role":33,"phone":190,"phoneExt":191,"email":192},"Ramon Perez Landaburo","305-665-4818","231","rperez@wpharma.com",{"name":194,"role":72,"phone":29,"phoneExt":29,"email":29},"Eddie Armas, MD",{"facility":196,"status":56,"city":197,"state":132,"zip":198,"country":47,"cosmosGeoPoint":199,"geoPoint":203,"contacts":204},"Clinical Research of West Florida","Tampa","33765",{"type":49,"coordinates":200},[201,202],-82.45843,27.94752,{"lat":202,"lon":201},[205,210],{"name":206,"role":33,"phone":207,"phoneExt":208,"email":209},"Jocelyn Evans","813-870-1292","129","jevans@crwf.com",{"name":211,"role":72,"phone":29,"phoneExt":29,"email":29},"Lon Lynn, MD",{"facility":213,"status":56,"city":148,"state":214,"zip":215,"country":47,"cosmosGeoPoint":216,"geoPoint":220,"contacts":221},"Arthritis Center of North Georgia - Gainesville","Georgia","30501",{"type":49,"coordinates":217},[218,219],-83.82407,34.29788,{"lat":219,"lon":218},[222,226],{"name":223,"role":33,"phone":224,"phoneExt":29,"email":225},"Cindy Valenzuela","770-531-3711","cvalenzuela@southeasternra.com",{"name":227,"role":72,"phone":29,"phoneExt":29,"email":29},"Brent Flickinger, MD",{"facility":229,"status":43,"city":230,"state":231,"zip":232,"country":47,"cosmosGeoPoint":233,"geoPoint":237,"contacts":29},"Great Lakes Clinical Trials","Chicago","Illinois","60640",{"type":49,"coordinates":234},[235,236],-87.65005,41.85003,{"lat":236,"lon":235},{"facility":239,"status":56,"city":240,"state":231,"zip":241,"country":47,"cosmosGeoPoint":242,"geoPoint":246,"contacts":247},"Advanced Quality Medical Research","Orland Park","60462",{"type":49,"coordinates":243},[244,245],-87.85394,41.63031,{"lat":245,"lon":244},[248,252],{"name":249,"role":33,"phone":250,"phoneExt":29,"email":251},"Selahaddin Hocaoglu","312-823-6800","selahaddin@m1-health.com",{"name":253,"role":72,"phone":29,"phoneExt":29,"email":29},"Dennis Levinson, MD",{"facility":255,"status":256,"city":257,"state":258,"zip":259,"country":47,"cosmosGeoPoint":260,"geoPoint":264,"contacts":29},"The Research Group of Lexington","ACTIVE_NOT_RECRUITING","Lexington","Kentucky","40503",{"type":49,"coordinates":261},[262,263],-84.47772,37.98869,{"lat":263,"lon":262},{"facility":266,"status":43,"city":267,"state":268,"zip":269,"country":47,"cosmosGeoPoint":270,"geoPoint":274,"contacts":29},"University of Michigan","Ann Arbor","Michigan","48109",{"type":49,"coordinates":271},[272,273],-83.74088,42.27756,{"lat":273,"lon":272},{"facility":276,"status":56,"city":277,"state":278,"zip":279,"country":47,"cosmosGeoPoint":280,"geoPoint":284,"contacts":285},"Montana Medical Research","Missoula","Montana","59808",{"type":49,"coordinates":281},[282,283],-113.994,46.87215,{"lat":283,"lon":282},[286,290],{"name":287,"role":33,"phone":288,"phoneExt":29,"email":289},"Eve Hickey","406-549-1124","ehickey@montanamedicalresearch.com",{"name":291,"role":72,"phone":29,"phoneExt":29,"email":29},"Clancy Cone, MD",{"facility":293,"status":256,"city":294,"state":294,"zip":295,"country":47,"cosmosGeoPoint":296,"geoPoint":300,"contacts":29},"NYU Langone","New York","10016",{"type":49,"coordinates":297},[298,299],-74.00597,40.71427,{"lat":299,"lon":298},{"facility":302,"status":43,"city":294,"state":294,"zip":303,"country":47,"cosmosGeoPoint":304,"geoPoint":306,"contacts":29},"IMA Clinical Research - Manhattan","10036",{"type":49,"coordinates":305},[298,299],{"lat":299,"lon":298},{"facility":308,"status":43,"city":309,"state":310,"zip":311,"country":47,"cosmosGeoPoint":312,"geoPoint":316,"contacts":29},"Altoona Research","Duncansville","Pennsylvania","16635",{"type":49,"coordinates":313},[314,315],-78.4339,40.42341,{"lat":315,"lon":314},{"facility":318,"status":56,"city":319,"state":320,"zip":321,"country":47,"cosmosGeoPoint":322,"geoPoint":326,"contacts":327},"Lower Country Rheumatology - Summerville","Summerville","South Carolina","29486",{"type":49,"coordinates":323},[324,325],-80.17565,33.0185,{"lat":325,"lon":324},[328,332],{"name":329,"role":33,"phone":330,"phoneExt":29,"email":331},"Eleanor Gardzalla","843-572-4840","egardzalla@articularishealthcare.com",{"name":333,"role":72,"phone":29,"phoneExt":29,"email":29},"Jennifer Murphy, MD",{"facility":335,"status":56,"city":336,"state":337,"zip":338,"country":47,"cosmosGeoPoint":339,"geoPoint":343,"contacts":344},"Amarillo Center of Clinical Research","Amarillo","Texas","79124",{"type":49,"coordinates":340},[341,342],-101.8313,35.222,{"lat":342,"lon":341},[345,349],{"name":346,"role":33,"phone":347,"phoneExt":29,"email":348},"Vallen White","806-352-2453","vwhite@allergyarts.com",{"name":350,"role":72,"phone":29,"phoneExt":29,"email":29},"Constantine Saadeh, MD",{"facility":352,"status":56,"city":353,"state":354,"zip":355,"country":47,"cosmosGeoPoint":356,"geoPoint":360,"contacts":361},"Utah Health - University of Utah Hospital","Salt Lake City","Utah","84108",{"type":49,"coordinates":357},[358,359],-111.89105,40.76078,{"lat":359,"lon":358},[362,366],{"name":363,"role":33,"phone":364,"phoneExt":29,"email":365},"Julieanne Hall","801-213-1558","julieanne.hall@hsc.utah.edu",{"name":367,"role":72,"phone":29,"phoneExt":29,"email":29},"Naomi Schlessinger, MD",{"facility":369,"status":43,"city":370,"state":371,"zip":372,"country":47,"cosmosGeoPoint":373,"geoPoint":377,"contacts":29},"Clinical Trial Site","Bothell","Washington","98021",{"type":49,"coordinates":374},[375,376],-122.2054,47.76232,{"lat":376,"lon":375},{"facility":379,"status":56,"city":380,"state":371,"zip":381,"country":47,"cosmosGeoPoint":382,"geoPoint":386,"contacts":387},"Arthritis Northwest","Spokane","99204",{"type":49,"coordinates":383},[384,385],-117.42908,47.65966,{"lat":385,"lon":384},[388,392],{"name":389,"role":33,"phone":390,"phoneExt":29,"email":391},"Terri Cone","509-838-6500","tcone@arthritisnw.com",{"name":393,"role":72,"phone":29,"phoneExt":29,"email":29},"Christopher Wright, MD",{"facility":395,"status":56,"city":396,"state":29,"zip":397,"country":398,"cosmosGeoPoint":399,"geoPoint":403,"contacts":404},"Centre Hospitalier Universitaire de Bordeaux - Hôpital Pellegrin","Bordeaux","33076","France",{"type":49,"coordinates":400},[401,402],-0.58046,44.84124,{"lat":402,"lon":401},[405,407],{"name":406,"role":33,"phone":29,"phoneExt":29,"email":29},"Clinical Contact",{"name":408,"role":72,"phone":29,"phoneExt":29,"email":29},"Marie-Elise Truchetet, MD",{"facility":410,"status":56,"city":411,"state":29,"zip":412,"country":398,"cosmosGeoPoint":413,"geoPoint":417,"contacts":418},"Hôpital Saint Philibert","Lomme","59462",{"type":49,"coordinates":414},[415,416],2.98715,50.64358,{"lat":416,"lon":415},[419,420],{"name":406,"role":33,"phone":29,"phoneExt":29,"email":29},{"name":421,"role":72,"phone":29,"phoneExt":29,"email":29},"Tristan Pascart, MD",{"facility":423,"status":56,"city":424,"state":29,"zip":29,"country":398,"cosmosGeoPoint":425,"geoPoint":429,"contacts":430},"Hôpital Lariboisière","Paris",{"type":49,"coordinates":426},[427,428],2.3488,48.85341,{"lat":428,"lon":427},[431],{"name":406,"role":33,"phone":29,"phoneExt":29,"email":29},{"facility":433,"status":56,"city":434,"state":29,"zip":29,"country":398,"cosmosGeoPoint":435,"geoPoint":439,"contacts":440},"CHU de Rouen - Hôpital Charles-Nicolle","Rouen",{"type":49,"coordinates":436},[437,438],1.09932,49.44313,{"lat":438,"lon":437},[441],{"name":406,"role":33,"phone":29,"phoneExt":29,"email":29},{"facility":443,"status":56,"city":444,"state":29,"zip":29,"country":445,"cosmosGeoPoint":446,"geoPoint":450,"contacts":451},"Emek Medical Center","Afula","Israel",{"type":49,"coordinates":447},[448,449],35.2892,32.60907,{"lat":449,"lon":448},[452,453],{"name":406,"role":33,"phone":29,"phoneExt":29,"email":29},{"name":454,"role":72,"phone":29,"phoneExt":29,"email":29},"Amir Bieber, MD",{"facility":456,"status":56,"city":457,"state":29,"zip":458,"country":445,"cosmosGeoPoint":459,"geoPoint":463,"contacts":464},"Carmel Medical Center","Haifa","3436212",{"type":49,"coordinates":460},[461,462],34.99928,32.81303,{"lat":462,"lon":461},[465,469],{"name":466,"role":33,"phone":467,"phoneExt":29,"email":468},"Noga Cohen","(+972)5240434341","nogacoh@clalit.org.il",{"name":470,"role":72,"phone":29,"phoneExt":29,"email":29},"Devy Zisman, MD",{"facility":472,"status":56,"city":473,"state":29,"zip":474,"country":445,"cosmosGeoPoint":475,"geoPoint":479,"contacts":480},"Rabin Medical Center - Beilinson and Hasharon","Petah Tikva","49100",{"type":49,"coordinates":476},[477,478],34.88747,32.08707,{"lat":478,"lon":477},[481,485],{"name":482,"role":33,"phone":483,"phoneExt":29,"email":484},"Yosra Khateb","(+972)39377105","yusrakha@clalit.org.il",{"name":486,"role":72,"phone":29,"phoneExt":29,"email":29},"Elisheva Pokroy-Shapira, MD",{"facility":488,"status":56,"city":489,"state":29,"zip":490,"country":445,"cosmosGeoPoint":491,"geoPoint":495,"contacts":496},"The Chaim Sheba Medical Center","Ramat Gan","5266202",{"type":49,"coordinates":492},[493,494],34.81065,32.08227,{"lat":494,"lon":493},[497,501],{"name":498,"role":33,"phone":499,"phoneExt":29,"email":500},"Revital Nawi","(+972)526668127","revital.nawi@sheba.health.gov.il",{"name":502,"role":72,"phone":29,"phoneExt":29,"email":29},"Howard Amital, MD",{"facility":504,"status":56,"city":505,"state":29,"zip":29,"country":506,"cosmosGeoPoint":507,"geoPoint":511,"contacts":512},"Reade Research BV","Amsterdam","Netherlands",{"type":49,"coordinates":508},[509,510],4.88969,52.37403,{"lat":510,"lon":509},[513,514],{"name":406,"role":33,"phone":29,"phoneExt":29,"email":29},{"name":515,"role":72,"phone":29,"phoneExt":29,"email":29},"Martijn Gerritsen, MD",{"facility":517,"status":56,"city":518,"state":29,"zip":519,"country":506,"cosmosGeoPoint":520,"geoPoint":524,"contacts":525},"Maastricht Universitair Medisch Centrum","Maastricht","6229 HX",{"type":49,"coordinates":521},[522,523],5.68889,50.84833,{"lat":523,"lon":522},[526,530],{"name":527,"role":33,"phone":528,"phoneExt":29,"email":529},"Christel Mertens","(+31)0433072099","christel.mertens@mumc.nl",{"name":531,"role":72,"phone":29,"phoneExt":29,"email":29},"Caroline Van Durme, MD",{"facility":533,"status":56,"city":534,"state":29,"zip":29,"country":506,"cosmosGeoPoint":535,"geoPoint":539,"contacts":540},"VieCuri Medisch Centrum","Venlo",{"type":49,"coordinates":536},[537,538],6.16806,51.37,{"lat":538,"lon":537},[541,543],{"name":542,"role":33,"phone":29,"phoneExt":29,"email":29},"Clinical Site",{"name":544,"role":72,"phone":29,"phoneExt":29,"email":29},"Tim Jansen, MD",{"facility":546,"status":43,"city":547,"state":29,"zip":548,"country":549,"cosmosGeoPoint":550,"geoPoint":554,"contacts":29},"Hospital Universitario san Juan de Alicante","Alicante","03010","Spain",{"type":49,"coordinates":551},[552,553],-0.48149,38.34517,{"lat":553,"lon":552},{"facility":556,"status":56,"city":557,"state":29,"zip":558,"country":549,"cosmosGeoPoint":559,"geoPoint":563,"contacts":564},"Hospital de la Santa Creu i Sant Pau","Barcelona","08025",{"type":49,"coordinates":560},[561,562],2.15899,41.38879,{"lat":562,"lon":561},[565,569],{"name":566,"role":33,"phone":567,"phoneExt":29,"email":568},"Júlia Bernárdez","(+34)935537112","JBernardez@santpau.cat",{"name":570,"role":72,"phone":29,"phoneExt":29,"email":29},"Cesar Diaz Torne, MD",{"facility":572,"status":56,"city":573,"state":29,"zip":574,"country":549,"cosmosGeoPoint":575,"geoPoint":579,"contacts":580},"Hospital Universitario de La Princesa","Madrid","28006",{"type":49,"coordinates":576},[577,578],-3.70256,40.4165,{"lat":578,"lon":577},[581,585],{"name":582,"role":33,"phone":583,"phoneExt":29,"email":584},"Helena Vazquez","(+34)915202473","helena.vazquez@salud.madrid.org",{"name":586,"role":72,"phone":29,"phoneExt":29,"email":29},"Esther Vicente Rabaneda, MD",{"facility":588,"status":56,"city":573,"state":29,"zip":589,"country":549,"cosmosGeoPoint":590,"geoPoint":592,"contacts":593},"Hospital Universitario Infanta Leonor","28031",{"type":49,"coordinates":591},[577,578],{"lat":578,"lon":577},[594,598],{"name":595,"role":33,"phone":596,"phoneExt":29,"email":597},"Pedro Torres","(+34)676146368","pedro.a.torresgomez.sc@gmail.com",{"name":599,"role":72,"phone":29,"phoneExt":29,"email":29},"Enrique Calvo Aranda, MD",{"type":601,"investigatorFullName":29,"investigatorTitle":29,"investigatorAffiliation":29,"oldNameTitle":29,"oldOrganization":29},"SPONSOR","100489857",false,"NCT05658575","Study of Dapansutrile Tablets in Subjects With an Acute Gout Flare","A Multi-Center Phase 2\u002F3 Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Safety and Efficacy Study of Dapansutrile Tablets in Subjects With an Acute Gout Flare","Inclusion Criteria:\n\n* Male and female subjects age 18 or older\n* Clinical diagnosis of gout according to the 2015 ACR\u002FEULAR Gout Classification Criteria:\n\nA) Diagnosis of gout must be confirmed in the target joint as indicated by either the presence of monosodium urate (MSU) crystals by microscopic evaluation of synovial fluid from the target joint or bursa OR by imaging evidence of urate deposition in the target joint or bursa at the Screening\u002FBaseline Visit\u002FStudy Day 1, or\n\nB) Documented history in the target joint or bursa ; or documented history of 2 or more gout flares in the previous 18 months\n\n* Confirmation of a gout flare in the target joint that began within 96 hours prior to the Screening\u002FBaseline Visit\n* Provide written informed consent and understand and comply with all trial requirements\n\nExclusion Criteria:\n\n* Presence of any palpable and visible tophi by physical examination\n* Has ≥ 4 joints with an acute gout flare at Screening\u002FBaseline\n* Presence of active rheumatoid arthritis or other acute inflammatory arthritis\n* Evidence\u002Fsuspicion of infectious\u002Fseptic arthritis\n* Clinically significant general pain or non-gout-related joint pain that would interfere with the subject's ability to accurately assess pain in the target joint\n* Known diagnosis of chronic kidney disease or known history of renal impairment\n* Positive test for severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2) infection, if tested, within 4 weeks of the Screening\u002FBaseline\n* Active malignancy or recent malignancy with any systemic anti-cancer treatment\n* Has a hypersensitivity or allergy to OLT1177® or other drugs in its class\n* Hypersensitivity or allergy to paracetamol\u002Facetaminophen\n* Use of any prohibited concomitant medications\u002Ftherapies over the periods defined in the protocol or planned use of any prohibited concomitant medications\u002Ftherapies during the Treatment Period (including the use of paracetamol\u002Facetaminophen within 4 hours prior to the Screening\u002FBaseline Visit or other pain medications within 12 hours prior to the Screening\u002F Baseline Visit\n* Use of any product containing paracetamol\u002Facetaminophen within 4 hours prior to the Screening\u002FBaseline Visit or planned use during the Treatment Period (with the exception of study-provided Rescue Medication \\[paracetamol\u002Facetaminophen\\], which is permitted after completion of the first target joint pain assessment on Study Day 4","ALL","18 Years",{"count":611,"type":612},300,"ESTIMATED","INTERVENTIONAL",[615,616],"PHASE2","PHASE3","The purpose of this trial is to investigate the efficacy and safety of dapansutrile (OLT1177®) tablets in subjects with an acute gout flare.",[619,620,621,622,623,624,625],"Acute Gout Flare","Gout Attack","Gout Flare","Gouty Arthritis","Gout","Arthritis","Joint Pain",[627,628,629,630,631,632,25,633,634,635,636,637,638,639,640,641,642,643,644],"gout","gouty arthritis","mono-articular arthritis","NLRP3","NLRP3 inhibitor","dapansutrile","joint pain","inflammation","gouty Inflammation","inflammasomes","IL-1 beta","IL-1 inflammation","autoinflammatory conditions","hyperuricemia","uric acid crystal","flare","small-molecule","therapeutic","2026-03-09",{"date":647,"type":648},"2026-03-11","ACTUAL",{"date":650,"type":648},"2023-01-06",{"date":652,"type":612},"2027-01-31",{"name":5,"class":6},40]