[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100615883":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":41,"responsibleParty":239,"collaborators":26,"id":241,"slug":26,"hasResults":242,"nctId":243,"briefTitle":244,"officialTitle":245,"acronym":26,"eligibilityCriteria":246,"healthyVolunteers":242,"sex":247,"minAge":248,"maxAge":249,"enrollmentInfo":250,"targetDuration":26,"studyType":253,"phases":254,"briefSummary":256,"conditions":257,"keywords":26,"overallStatus":44,"whyStopped":26,"lastUpdateSubmitDate":259,"lastUpdatePostDateStruct":260,"startDateStruct":263,"completionDateStruct":265,"leadSponsor":267,"locationsCount":268},{"fullName":5,"class":6},"Enveda Therapeutics","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"ENV-294 Treatment Arm","EXPERIMENTAL","ENV-294 will be administered to those participants randomized to the treatment arm.",[13],"Drug: ENV-294",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo Arm","PLACEBO_COMPARATOR","A placebo will be administered to those participants randomized to the placebo arm.",[19],"Drug: Placebo",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","ENV-294","ENV-294 is an orally administered investigational drug supplied as tablets. Participants receive ENV-294 once daily by mouth for 12 weeks.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Placebo","Matching oral tablet that does not contain active drug. Administered once daily by mouth for 12 weeks under the same conditions as the investigational product.",[15],[32],{"name":33,"affiliation":34,"role":35},"Gurpreet Ahluwalia, PhD","Enveda Therapeutics, Inc.","STUDY_DIRECTOR",[37],{"name":38,"role":39,"phone":26,"phoneExt":26,"email":40},"Clinical Operations","CONTACT","env-294.clinicaltrials@enveda.com",[42,55,64,73,81,89,94,102,111,120,128,137,146,154,162,170,179,188,196,205,214,222,230],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":26},"Enveda Investigative Site","RECRUITING","Birmingham","Alabama","35244","United States",{"type":50,"coordinates":51},"Point",[52,53],-86.80249,33.52066,{"lat":53,"lon":52},{"facility":43,"status":44,"city":56,"state":57,"zip":58,"country":48,"cosmosGeoPoint":59,"geoPoint":63,"contacts":26},"Hot Springs","Arkansas","71913",{"type":50,"coordinates":60},[61,62],-93.05518,34.5037,{"lat":62,"lon":61},{"facility":43,"status":44,"city":65,"state":66,"zip":67,"country":48,"cosmosGeoPoint":68,"geoPoint":72,"contacts":26},"Beverly Hills","California","90212",{"type":50,"coordinates":69},[70,71],-118.40036,34.07362,{"lat":71,"lon":70},{"facility":43,"status":44,"city":74,"state":66,"zip":75,"country":48,"cosmosGeoPoint":76,"geoPoint":80,"contacts":26},"Fremont","94538",{"type":50,"coordinates":77},[78,79],-121.98857,37.54827,{"lat":79,"lon":78},{"facility":43,"status":44,"city":82,"state":66,"zip":83,"country":48,"cosmosGeoPoint":84,"geoPoint":88,"contacts":26},"San Diego","92121",{"type":50,"coordinates":85},[86,87],-117.16472,32.71571,{"lat":87,"lon":86},{"facility":43,"status":44,"city":82,"state":66,"zip":90,"country":48,"cosmosGeoPoint":91,"geoPoint":93,"contacts":26},"92123",{"type":50,"coordinates":92},[86,87],{"lat":87,"lon":86},{"facility":43,"status":44,"city":95,"state":66,"zip":96,"country":48,"cosmosGeoPoint":97,"geoPoint":101,"contacts":26},"West Hills","91307",{"type":50,"coordinates":98},[99,100],-118.64398,34.19731,{"lat":100,"lon":99},{"facility":43,"status":44,"city":103,"state":104,"zip":105,"country":48,"cosmosGeoPoint":106,"geoPoint":110,"contacts":26},"Atlanta","Georgia","30327",{"type":50,"coordinates":107},[108,109],-84.38798,33.749,{"lat":109,"lon":108},{"facility":43,"status":44,"city":112,"state":113,"zip":114,"country":48,"cosmosGeoPoint":115,"geoPoint":119,"contacts":26},"New Albany","Indiana","47150",{"type":50,"coordinates":116},[117,118],-85.82413,38.28562,{"lat":118,"lon":117},{"facility":43,"status":44,"city":121,"state":113,"zip":122,"country":48,"cosmosGeoPoint":123,"geoPoint":127,"contacts":26},"West Lafayette","47906",{"type":50,"coordinates":124},[125,126],-86.90807,40.42587,{"lat":126,"lon":125},{"facility":43,"status":44,"city":129,"state":130,"zip":131,"country":48,"cosmosGeoPoint":132,"geoPoint":136,"contacts":26},"Louisville","Kentucky","40217",{"type":50,"coordinates":133},[134,135],-85.75941,38.25424,{"lat":135,"lon":134},{"facility":43,"status":44,"city":138,"state":139,"zip":140,"country":48,"cosmosGeoPoint":141,"geoPoint":145,"contacts":26},"Auburn Hills","Michigan","48326",{"type":50,"coordinates":142},[143,144],-83.2341,42.68753,{"lat":144,"lon":143},{"facility":43,"status":44,"city":147,"state":139,"zip":148,"country":48,"cosmosGeoPoint":149,"geoPoint":153,"contacts":26},"Bay City","48706",{"type":50,"coordinates":150},[151,152],-83.88886,43.59447,{"lat":152,"lon":151},{"facility":43,"status":44,"city":155,"state":139,"zip":156,"country":48,"cosmosGeoPoint":157,"geoPoint":161,"contacts":26},"Clinton Township","48038",{"type":50,"coordinates":158},[159,160],-82.91992,42.58698,{"lat":160,"lon":159},{"facility":43,"status":44,"city":163,"state":139,"zip":164,"country":48,"cosmosGeoPoint":165,"geoPoint":169,"contacts":26},"Warren","48088",{"type":50,"coordinates":166},[167,168],-83.01304,42.49044,{"lat":168,"lon":167},{"facility":43,"status":44,"city":171,"state":172,"zip":173,"country":48,"cosmosGeoPoint":174,"geoPoint":178,"contacts":26},"Las Vegas","Nevada","89145",{"type":50,"coordinates":175},[176,177],-115.13722,36.17497,{"lat":177,"lon":176},{"facility":43,"status":44,"city":180,"state":181,"zip":182,"country":48,"cosmosGeoPoint":183,"geoPoint":187,"contacts":26},"Canton","Ohio","44718",{"type":50,"coordinates":184},[185,186],-81.37845,40.79895,{"lat":186,"lon":185},{"facility":43,"status":44,"city":189,"state":181,"zip":190,"country":48,"cosmosGeoPoint":191,"geoPoint":195,"contacts":26},"Mayfield Heights","44124",{"type":50,"coordinates":192},[193,194],-81.4579,41.51922,{"lat":194,"lon":193},{"facility":43,"status":44,"city":197,"state":198,"zip":199,"country":48,"cosmosGeoPoint":200,"geoPoint":204,"contacts":26},"Camp Hill","Pennsylvania","17011",{"type":50,"coordinates":201},[202,203],-76.91997,40.23981,{"lat":203,"lon":202},{"facility":43,"status":44,"city":206,"state":207,"zip":208,"country":48,"cosmosGeoPoint":209,"geoPoint":213,"contacts":26},"Arlington","Texas","76011",{"type":50,"coordinates":210},[211,212],-97.10807,32.73569,{"lat":212,"lon":211},{"facility":43,"status":44,"city":215,"state":207,"zip":216,"country":48,"cosmosGeoPoint":217,"geoPoint":221,"contacts":26},"Houston","77004",{"type":50,"coordinates":218},[219,220],-95.36327,29.76328,{"lat":220,"lon":219},{"facility":43,"status":44,"city":223,"state":207,"zip":224,"country":48,"cosmosGeoPoint":225,"geoPoint":229,"contacts":26},"San Antonio","78218",{"type":50,"coordinates":226},[227,228],-98.49363,29.42412,{"lat":228,"lon":227},{"facility":43,"status":44,"city":231,"state":232,"zip":233,"country":48,"cosmosGeoPoint":234,"geoPoint":238,"contacts":26},"Norfolk","Virginia","23502",{"type":50,"coordinates":235},[236,237],-76.28522,36.84681,{"lat":237,"lon":236},{"type":240,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100615883",false,"NCT07298395","Study of ENV-294 in Adults With Moderate-to-Severe Atopic Dermatitis","A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, 12-Week Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of ENV-294 in Adult Participants With Moderate-to-Severe Atopic Dermatitis","Inclusion Criteria:\n\n* Have chronic atopic dermatitis that was diagnosed at least 12 months prior to the first study visit\n* Have moderate-to-severe AD at screening and baseline as defined by the following criteria:\n\n  * A vIGA score of 3 (moderate) or 4 (severe)\n  * EASI score of ≥16\n  * BSA ≥10%\n  * PP-NRS score of ≥4\n* Have had either a poor response or intolerance to topical treatments for atopic dermatitis (such as corticosteroids) within the past 6 months\n* Use a bland moisturizer at least daily\n\nExclusion Criteria:\n\n* Current or recurrent medical conditions that could affect the study drug or study assessments\n* Any illness that could impact participant safety or active infections\n* Ongoing skin condition or large tattoos that would interfere with clinical assessment\n* Clinically significant skin infection requiring treatment\n* Clinically significant abnormal laboratory assessments at screening","ALL","18 Years","75 Years",{"count":251,"type":252},60,"ESTIMATED","INTERVENTIONAL",[255],"PHASE2","The goal of this clinical trial is to learn about the safety and effectiveness of ENV-294 in adults with moderate to severe atopic dermatitis.\n\nThe main questions it will answer are:\n\n* Is there an impact on the severity and area of atopic dermatitis when participants take ENV-294\n* What medical problems do participants have when taking ENV-294\n\nParticipants will:\n\n* Take drug ENV-294 or a placebo once every day for 12 weeks\n* Visit the clinic every 2 to 4 weeks for checkups and tests\n* Keep a diary of their symptoms and when they took their study drug\n* Return to the clinic for the final study visit at approximately week 16",[258],"Atopic Dermatitis (AD)","2026-06-02",{"date":261,"type":262},"2026-06-04","ACTUAL",{"date":264,"type":262},"2025-12-22",{"date":266,"type":252},"2026-12",{"name":5,"class":6},23]