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Subjects without immunoparalysis (a whole blood ex vivo LPS-induced TNF-alpha production capacity \\\u003C 200 pg\u002Fml) and a serum ferritin level of 500 - 2,000 ng\u002Fml or a serum C-reactive protein (CRP) ≥ 4 mg\u002Fdl will be eligible for randomization, along with subjects with a serum ferritin level of 2,000 - 10,000 ng\u002Fml regardless of their TNF-alpha response. 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of myeloablative therapy within the previous 14 days; OR\n* Known allergy to anakinra, or E. coli-derived products; OR\n* Known pregnancy; OR\n* Lactating females; OR\n* Receipt of anakinra within the previous 28 days; OR\n* Resolution of MODS by MODS Day 2; OR\n* Previous enrollment in the TRIPS study.","ALL","1 Day","17 Years",{"count":518,"type":519},500,"ESTIMATED","INTERVENTIONAL",[522,523],"PHASE2","PHASE3","The TRIPS study is a prospective, multi-center, double-blind, adaptively randomized, placebo-controlled clinical trial of the drug anakinra for reversal of moderate to severe hyperinflammation in children with sepsis-induced multiple organ dysfunction syndrome (MODS).",[526],"Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome (MODS)","2026-03-11",{"date":529,"type":530},"2026-03-13","ACTUAL",{"date":532,"type":530},"2022-06-14",{"date":534,"type":519},"2028-08-31",{"name":5,"class":6},32]