[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100529472":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":34,"locations":44,"responsibleParty":348,"collaborators":350,"id":364,"slug":25,"hasResults":365,"nctId":366,"briefTitle":367,"officialTitle":367,"acronym":368,"eligibilityCriteria":369,"healthyVolunteers":365,"sex":370,"minAge":371,"maxAge":25,"enrollmentInfo":372,"targetDuration":25,"studyType":375,"phases":376,"briefSummary":378,"conditions":379,"keywords":382,"overallStatus":47,"whyStopped":25,"lastUpdateSubmitDate":384,"lastUpdatePostDateStruct":385,"startDateStruct":388,"completionDateStruct":390,"leadSponsor":392,"locationsCount":393},{"fullName":5,"class":6},"Hamilton Health Sciences Corporation","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Tideglusib","ACTIVE_COMPARATOR","Randomization to Tideglusib 1g po daily or matching placebo",[13],"Drug: Tideglusib",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo","PLACEBO_COMPARATOR","Randomization to matching placebo 1g po daily",[19],"Drug: Placebo",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Tideglusib 1g po daily",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"Matching placebo 1g po daily",[15],[30],{"name":31,"affiliation":32,"role":33},"Jason D Roberts, MD MAS","McMaster University and Population Health Research Institute","PRINCIPAL_INVESTIGATOR",[35,41],{"name":36,"role":37,"phone":38,"phoneExt":39,"email":40},"Jason Roberts, MD MAS","CONTACT","905-521-2100","40354","jason.roberts@phri.ca",{"name":42,"role":37,"phone":25,"phoneExt":25,"email":43},"Maha Mushtaha","maha.mushtaha@phri.ca",[45,68,92,110,133,154,176,191,208,222,238,259,273,284,306,317,330],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"University of Calgary","RECRUITING","Calgary","Alberta","T2N 2T9","Canada",{"type":53,"coordinates":54},"Point",[55,56],-114.08529,51.05011,{"lat":56,"lon":55},[59,63,65],{"name":60,"role":37,"phone":61,"phoneExt":25,"email":62},"Erkan Ilhan","403-210-6047","erkan.ilhan@ucalgary.ca",{"name":64,"role":33,"phone":25,"phoneExt":25,"email":25},"Erkan Ilhan, MD",{"name":66,"role":67,"phone":25,"phoneExt":25,"email":25},"Patrick Champagne, MD","SUB_INVESTIGATOR",{"facility":69,"status":47,"city":70,"state":71,"zip":72,"country":51,"cosmosGeoPoint":73,"geoPoint":77,"contacts":78},"University of British Columbia","Vancouver","British Columbia","V6Z 1Y6",{"type":53,"coordinates":74},[75,76],-123.11934,49.24966,{"lat":76,"lon":75},[79,84,86,88,90],{"name":80,"role":37,"phone":81,"phoneExt":82,"email":83},"Thomas Roston","604-682-2344","66863","rostonm@alumni.ubc.ca",{"name":85,"role":33,"phone":25,"phoneExt":25,"email":25},"Thomas M Roston, MD PhD",{"name":87,"role":33,"phone":25,"phoneExt":25,"email":25},"Zachary Laksman, MD MSc",{"name":89,"role":33,"phone":25,"phoneExt":25,"email":25},"Andrew D Krahn, MD",{"name":91,"role":67,"phone":25,"phoneExt":25,"email":25},"Gnalini Sathananthan, MD",{"facility":93,"status":47,"city":94,"state":71,"zip":95,"country":51,"cosmosGeoPoint":96,"geoPoint":100,"contacts":101},"Victoria Cardiac Arrhythmia Trials Inc.","Victoria","V8Z 0B9",{"type":53,"coordinates":97},[98,99],-123.35155,48.4359,{"lat":99,"lon":98},[102,106,108],{"name":103,"role":37,"phone":104,"phoneExt":25,"email":105},"May Woodburn","250-595-0400","mwoodburn@catrials.org",{"name":107,"role":33,"phone":25,"phoneExt":25,"email":25},"Martin van Zyl, MD",{"name":109,"role":67,"phone":25,"phoneExt":25,"email":25},"Karan Shetty, MD",{"facility":111,"status":47,"city":112,"state":113,"zip":114,"country":51,"cosmosGeoPoint":115,"geoPoint":119,"contacts":120},"NL Health Services","St. John's","Newfoundland and Labrador","A1B 3V6",{"type":53,"coordinates":116},[117,118],-52.70931,47.56494,{"lat":118,"lon":117},[121,125,127,129,131],{"name":122,"role":37,"phone":123,"phoneExt":25,"email":124},"Stephen Duffett","709-752-4636","stephen.duffett@easternhealth.ca",{"name":126,"role":33,"phone":25,"phoneExt":25,"email":25},"Stephen Duffett, MD",{"name":128,"role":33,"phone":25,"phoneExt":25,"email":25},"Sean Connors, MD",{"name":130,"role":33,"phone":25,"phoneExt":25,"email":25},"Kathy Hodgkinson, PhD",{"name":132,"role":67,"phone":25,"phoneExt":25,"email":25},"Ashar Pirzada, MD",{"facility":134,"status":47,"city":135,"state":136,"zip":137,"country":51,"cosmosGeoPoint":138,"geoPoint":142,"contacts":143},"Nova Scotia Health","Halifax","Nova Scotia","B3H 2Y9",{"type":53,"coordinates":139},[140,141],-63.57688,44.64269,{"lat":141,"lon":140},[144,148,150,152],{"name":145,"role":37,"phone":146,"phoneExt":25,"email":147},"Victoria Newman","902-473-5341","victoria.newman@nshealth.ca",{"name":149,"role":33,"phone":25,"phoneExt":25,"email":25},"David Lee, MD",{"name":151,"role":33,"phone":25,"phoneExt":25,"email":25},"Ciorsti MacIntyre, MD",{"name":153,"role":67,"phone":25,"phoneExt":25,"email":25},"Daniel Belliveau, MD",{"facility":155,"status":47,"city":156,"state":157,"zip":158,"country":51,"cosmosGeoPoint":159,"geoPoint":163,"contacts":164},"Hamilton General Hospital","Hamilton","Ontario","L8L 2X2",{"type":53,"coordinates":160},[161,162],-79.84963,43.25011,{"lat":162,"lon":161},[165,170,172,174],{"name":166,"role":37,"phone":167,"phoneExt":168,"email":169},"Jeff Healey","905-527-0271","40312","jeff.healey@phri.ca",{"name":171,"role":33,"phone":25,"phoneExt":25,"email":25},"Jeff S Healey, MD",{"name":173,"role":67,"phone":25,"phoneExt":25,"email":25},"Javier Ganame, MD",{"name":175,"role":67,"phone":25,"phoneExt":25,"email":25},"William F McIntyre, MD PhD FRCPC",{"facility":177,"status":178,"city":179,"state":157,"zip":180,"country":51,"cosmosGeoPoint":181,"geoPoint":185,"contacts":186},"Kingston General Hospital","NOT_YET_RECRUITING","Kingston","K7L 2V7",{"type":53,"coordinates":182},[183,184],-76.48098,44.22976,{"lat":184,"lon":183},[187,189],{"name":188,"role":33,"phone":25,"phoneExt":25,"email":25},"Chris Simpson, MD",{"name":190,"role":67,"phone":25,"phoneExt":25,"email":25},"Amar Thakrar, MD",{"facility":192,"status":47,"city":193,"state":157,"zip":194,"country":51,"cosmosGeoPoint":195,"geoPoint":199,"contacts":200},"London Health Sciences Centre","London","N6A 5A5",{"type":53,"coordinates":196},[197,198],-81.23304,42.98339,{"lat":198,"lon":197},[201,206],{"name":202,"role":37,"phone":203,"phoneExt":204,"email":205},"Sara El-Richani","519-685-8500","36808","lhrp.research@lhsc.on.ca",{"name":207,"role":33,"phone":25,"phoneExt":25,"email":25},"Habib R Khan, MD",{"facility":209,"status":178,"city":210,"state":157,"zip":211,"country":51,"cosmosGeoPoint":212,"geoPoint":216,"contacts":217},"Newmarket Electrophysiologist Research Group 'NERG'","Newmarket","L3Y 2P9",{"type":53,"coordinates":213},[214,215],-79.46631,44.05011,{"lat":215,"lon":214},[218,220],{"name":219,"role":33,"phone":25,"phoneExt":25,"email":25},"Mouhannad Sadek, MD",{"name":221,"role":67,"phone":25,"phoneExt":25,"email":25},"Molly Thangaroopan, MD",{"facility":223,"status":178,"city":224,"state":157,"zip":225,"country":51,"cosmosGeoPoint":226,"geoPoint":230,"contacts":231},"University of Ottawa Heart Institute","Ottawa","K1Y 4W7",{"type":53,"coordinates":227},[228,229],-75.69812,45.41117,{"lat":229,"lon":228},[232,234,236],{"name":233,"role":33,"phone":25,"phoneExt":25,"email":25},"Simon Hansom, MD",{"name":235,"role":33,"phone":25,"phoneExt":25,"email":25},"Martin Green, MD",{"name":237,"role":67,"phone":25,"phoneExt":25,"email":25},"Lawrence Lau, MD",{"facility":239,"status":47,"city":240,"state":157,"zip":241,"country":51,"cosmosGeoPoint":242,"geoPoint":246,"contacts":247},"Heart Health Institute Research Inc","Scarborough Village","M1E 4B9",{"type":53,"coordinates":243},[244,245],-79.22124,43.73899,{"lat":245,"lon":244},[248,253,255,257],{"name":249,"role":37,"phone":250,"phoneExt":251,"email":252},"Emily Magimaidoss","416-281-9499","3015","emagimaidoss@hearthealthinstitute.net",{"name":254,"role":33,"phone":25,"phoneExt":25,"email":25},"Bhavanesh Makanjee, MD",{"name":256,"role":33,"phone":25,"phoneExt":25,"email":25},"Derek Yung, MD",{"name":258,"role":67,"phone":25,"phoneExt":25,"email":25},"Natalie Ho, MD",{"facility":260,"status":178,"city":261,"state":157,"zip":262,"country":51,"cosmosGeoPoint":263,"geoPoint":267,"contacts":268},"Sunnybrook Health Sciences Centre","Toronto","M4N 3M5",{"type":53,"coordinates":264},[265,266],-79.39864,43.70643,{"lat":266,"lon":265},[269,271],{"name":270,"role":33,"phone":25,"phoneExt":25,"email":25},"Christopher Cheung, MD",{"name":272,"role":67,"phone":25,"phoneExt":25,"email":25},"Idan Roifman, MD",{"facility":274,"status":178,"city":261,"state":157,"zip":275,"country":51,"cosmosGeoPoint":276,"geoPoint":278,"contacts":279},"St. Michael's Hospital","M5B 1W8",{"type":53,"coordinates":277},[265,266],{"lat":266,"lon":265},[280,282],{"name":281,"role":33,"phone":25,"phoneExt":25,"email":25},"Paul Angaran, MD",{"name":283,"role":67,"phone":25,"phoneExt":25,"email":25},"Geraldine Ong, MD",{"facility":285,"status":47,"city":286,"state":287,"zip":288,"country":51,"cosmosGeoPoint":289,"geoPoint":293,"contacts":294},"Montreal Heart Institute","Montreal","Quebec","H1T 1C8",{"type":53,"coordinates":290},[291,292],-73.58781,45.50884,{"lat":292,"lon":291},[295,300,302,304],{"name":296,"role":37,"phone":297,"phoneExt":298,"email":299},"Jeremie Cortial","514-376-3330","2293","jeremie.cortial@icm-mhi.org",{"name":301,"role":33,"phone":25,"phoneExt":25,"email":25},"Julia Cadrin-Tourigny, MD PhD",{"name":303,"role":33,"phone":25,"phoneExt":25,"email":25},"Rafik Tadros, MD PhD",{"name":305,"role":67,"phone":25,"phoneExt":25,"email":25},"Marie Chaix, MD",{"facility":307,"status":178,"city":286,"state":287,"zip":308,"country":51,"cosmosGeoPoint":309,"geoPoint":311,"contacts":312},"McGill University Health Centre","H4A 3J1",{"type":53,"coordinates":310},[291,292],{"lat":292,"lon":291},[313,315],{"name":314,"role":33,"phone":25,"phoneExt":25,"email":25},"Jacqueline Joza, MD",{"name":316,"role":67,"phone":25,"phoneExt":25,"email":25},"Michael Chetrit, MD",{"facility":318,"status":178,"city":286,"state":287,"zip":319,"country":51,"cosmosGeoPoint":320,"geoPoint":322,"contacts":323},"Hopital du Sacré-Coeur de Montréal","H4J 1C5",{"type":53,"coordinates":321},[291,292],{"lat":292,"lon":291},[324,326,328],{"name":325,"role":33,"phone":25,"phoneExt":25,"email":25},"Leila Laroussi, MD",{"name":327,"role":33,"phone":25,"phoneExt":25,"email":25},"Alexios Hadjis, MD",{"name":329,"role":67,"phone":25,"phoneExt":25,"email":25},"Nadia Boule-Laghlazi, MD",{"facility":331,"status":47,"city":332,"state":287,"zip":333,"country":51,"cosmosGeoPoint":334,"geoPoint":338,"contacts":339},"University Institute of Cardiology and Pneumology of Quebec","Québec","G1V 4G5",{"type":53,"coordinates":335},[336,337],-71.21454,46.81228,{"lat":337,"lon":336},[340,344,346],{"name":341,"role":37,"phone":342,"phoneExt":25,"email":343},"Dr. Christian Steinberg","418-656-8711","christian.steinberg@criucpq.ulaval.ca",{"name":345,"role":33,"phone":25,"phoneExt":25,"email":25},"Christian Steinberg, MD",{"name":347,"role":67,"phone":25,"phoneExt":25,"email":25},"Jonathan Beaudoin, MD",{"type":349,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[351,354,357,360,362],{"name":352,"class":353},"Canadian Institutes of Health Research (CIHR)","OTHER_GOV",{"name":355,"class":356},"Canadian SADS","UNKNOWN",{"name":358,"class":359},"AMO Pharma Limited","INDUSTRY",{"name":361,"class":356},"Hearts in Rhythm Organization (HiRO)",{"name":363,"class":6},"Population Health Research Institute","100529472",false,"NCT06174220","Targeted Therapy With Glycogen Synthase Kinase-3 Inhibition for Arrhythmogenic Cardiomyopathy","TaRGET","Inclusion Criteria:\n\n* A pathogenic or likely pathogenic desmosomal (PKP2, DSG2, DSC2, DSP, or JUP\\*) rare variant OR the TMEM43-p.S358L variant\n\n  \\*JUP carriers must be homozygous or compound heterozygous\n* Mean ≥ 500 PVCs per 24 hours on a baseline screening 7-day Holter monitor\n* Clinical ACM diagnosis or recognition of genetic carrier status for ≥ 6 months prior to screening\n\nExclusion Criteria:\n\n* NYHA class IV heart failure\n* Ventricular scar secondary to coronary artery disease\n* Initiation, cessation, or dose change of a Class I or III anti-arrhythmic drug in the 3 months prior to screening\n* Any potentially harmful chronic liver disease\n* ALT value \\> 2X the upper limit of the normal reference range at Screening\n* Total bilirubin value greater than the upper limit of the normal reference range at Screening, unless documented Gilbert's syndrome. For individuals with Gilbert's syndrome, total bilirubin value greater than 2-fold the upper limit of the normal reference range at Screening.\n* A history of alcohol or illicit substance use disorders\n* Regular and long-term use of strong CYP3A4 inhibitors, including clarithromycin, telithromycin, ketoconazole, itraconazole, posaconazole, nefazodone, idinavir and ritonavir\n* Serum creatinine \\> 150 micromole\u002FL or creatinine clearance ≤ 60 mL\u002Fmin (according to Cockcroft-Gault formula) at Screening\n* Pregnant at time of enrollment and women of childbearing age who do not use a highly effective form of contraception\n* Males, engaged in sexual relations with a female of child-bearing potential, not using an acceptable contraceptive method if not surgically sterile\n* Patients unwilling to provide informed consent or comply with follow-up\n* Hypersensitivity to tideglusib or any components of its formulation, including allergy to strawberry\n* Concurrent use of drugs metabolized by CYP3A4 with a narrow therapeutic window e.g. warfarin and digoxin","ALL","18 Years",{"count":373,"type":374},120,"ESTIMATED","INTERVENTIONAL",[377],"PHASE2","The TaRGET study is a multi-centre, prospective, randomized, double-blind, placebo-controlled trial designed to evaluate the potential therapeutic efficacy of tideglusib, a glycogen synthase kinase-3 β inhibitor, in genotype positive arrhythmogenic cardiomyopathy.",[380,381],"Arrhythmogenic Cardiomyopathy","Arrhythmogenic Right Ventricular Cardiomyopathy",[383],"sudden cardiac death, ventricular cardiomyopathy, genetics, arrhythmia","2026-03-10",{"date":386,"type":387},"2026-03-12","ACTUAL",{"date":389,"type":387},"2025-03-21",{"date":391,"type":374},"2027-07-01",{"name":5,"class":6},17]