[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100588150":3},{"organization":4,"outcomesModule":7,"designInfo":27,"detailedDescription":26,"studyPopulation":26,"armGroups":35,"interventions":51,"overallOfficials":26,"centralContacts":61,"locations":71,"responsibleParty":83,"collaborators":26,"id":87,"slug":26,"hasResults":88,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":26,"eligibilityCriteria":92,"healthyVolunteers":88,"sex":93,"minAge":94,"maxAge":95,"enrollmentInfo":96,"targetDuration":26,"studyType":99,"phases":100,"briefSummary":102,"conditions":103,"keywords":105,"overallStatus":74,"whyStopped":26,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":119},{"fullName":5,"class":6},"Al-Nahrain University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":21,"otherOutcomes":26},[9,13,17],{"measure":10,"description":11,"timeFrame":12},"measuring the value of resistance index (RI) of the sub-endometrial blood vessels","We will measure the value of the resistance index (RI) using the transvaginal ultrasound Doppler study. For each patient, RI will be measured twice: the first measure will be done before the intervention on the day of oocyte retrieval, and the second measure will be performed after the intervention on the day of embryo transfer.\n\nwe will calculate RI according to the following equation Resistance index (RI)= \\[Peak Systolic Velocity (PSV) cm\u002Fsec - End Diastolic Velocity (EDV) cm\u002Fsec \\] \u002F Peak Systolic Velocity (PSV) cm\u002Fsec Then a statistical comparison will be made to evaluate the difference between the two readings to study the effect of the intervention on the measured parameter for each group.","for each participant twice measure will be done for (RI). The first measure will be performed on the day of oocyte retrieval and the second measure on the day of embryo transfer which is done 3-5 days after oocyte retrieval.",{"measure":14,"description":15,"timeFrame":16},"measuring the value of sub- endometrial vessels pulsatile index (PI)","We will measure the value of the pulsatile index (PI) using the transvaginal ultrasound Doppler study. PI will be measured twice for each patient: once before the oocyte retrieval intervention and once after the embryo transfer intervention.\n\nthen PI will be calculated according to the following equation Pulsatility Index (PI) = \\[Peak Systolic Velocity (PSV) cm\u002Fsec - end Diastolic Velocity (EDV) cm\u002Fsec \\] \u002F Mean Velocity (MV) cm\u002Fsec Then a statistical comparison will be made to evaluate the difference between the two readings to study the effect of the intervention on the measured parameter for each group.","for each participant twice measure will be done for PI. The first measure is on the day of oocyte retrieval and the second measure on the day of embryo transfer which is done 3-5 days after oocyte retrieval.",{"measure":18,"description":19,"timeFrame":20},"measuring the value of peak systolic to end diastolic ratio (S\u002FD) of the sub-endometrial blood vessels","We will measure the value of the peak systolic to end diastolic ratio (S\u002FD) using the transvaginal ultrasound Doppler study. For each patient, S\u002FD will be measured twice: the first measure will be done before the intervention on the day of oocyte retrieval, and the second measure will be performed after the intervention on the day of embryo transfer.\n\nS\u002FD will be calculated according to the following equation S\u002FD= Peak Systolic Velocity (PSV) cm\u002Fsec \u002FEnd Diastolic Velocity (ED) cm\u002Fsec\n\nThen a statistical comparison will be made to evaluate the difference between the two readings to study the effect of the intervention on the measured parameter for each group.","for each participant twice measure will be done for S\u002FD. The first measure is on the day of oocyte retrieval and the second measure on the day of embryo transfer which is done 3-5 days after oocyte retrieval.",[22],{"measure":23,"description":24,"timeFrame":25},"measuring serum level of beta human chorionic gonadotropin","We will assess the effect of hyaluronic acid intrauterine wash on improving the pregnancy outcome in infertile patients undergoing intracytoplasmic sperm injection (ICSI). Two weeks after the day of oocyte retrieval, we will measure the serum level of beta human chorionic gonadotropin (B HCG) in mIU\u002FmL to test for successful pregnancy. The pregnancy rates will be compared between the study groups using statistical analysis to see how effective hyaluronic acid intrauterine wash is on pregnancy outcomes compared to the PRP and control groups.","2 weeks from the day of oocyte retrieval",null,{"allocation":28,"interventionModel":29,"interventionModelDescription":26,"primaryPurpose":30,"observationalModel":26,"timePerspective":26,"maskingInfo":31},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":32,"maskingDescription":26,"whoMasked":33},"SINGLE",[34],"PARTICIPANT",[36,42,47],{"label":37,"type":38,"description":39,"interventionNames":40},"the uterine cavity washed with hyaluronic acid preparation on the day of ooc","EXPERIMENTAL","40 infertile patients had their uterine cavity with hyaluronic acid preparation on the day of oocytes retrieval in ICSI",[41],"Drug: Hyaluronic Acid (HA)",{"label":43,"type":38,"description":44,"interventionNames":45},"40 infertile females had their uterine cavity washed with PRP preparation","40 infertile females had their uterine cavity washed with PRP preparation on the day of oocytes retrieval in ICSI",[46],"Drug: platlet rich plasma (PRP)",{"label":48,"type":49,"description":50,"interventionNames":26},"40 infertile females with no intervention for their uterus","NO_INTERVENTION","40 infertile females with no intervention for their uterus on the day of oocytes retrieval in ICSI",[52,57],{"type":53,"name":54,"description":55,"armGroupLabels":56,"otherNames":26},"DRUG","Hyaluronic Acid (HA)","hyaluronic acid PRP preparation used to wash the endometrium on the day of oocytes retrieval",[37],{"type":53,"name":58,"description":59,"armGroupLabels":60,"otherNames":26},"platlet rich plasma (PRP)","PRP preparation used to wash the uterine cavity on the day of oocytes retrieval",[43],[62,67],{"name":63,"role":64,"phone":65,"phoneExt":26,"email":66},"ghada bassim raaf, Ph.D.","CONTACT","+9647714728261","ghadaalanssari@yahoo.co.uk",{"name":68,"role":64,"phone":69,"phoneExt":26,"email":70},"lubna alanbari, Ph.D.","07729420158","dr.lubna@st.nahrainuniv.edu.iq",[72],{"facility":73,"status":74,"city":75,"state":76,"zip":26,"country":77,"countryCode":78,"cosmosGeoPoint":26,"geoPoint":26,"contacts":79},"high institute for infertility diagnosis and ARTS","RECRUITING","AL-Kadimya","Baghdad Governorate","Iraq","IQ",[80],{"name":81,"role":64,"phone":82,"phoneExt":26,"email":70},"Lubna Amer Al anbari, Ph.D.","00964 7729420158",{"type":84,"investigatorFullName":85,"investigatorTitle":86,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","ghada bassim raaf","clinical professor","100588150",false,"NCT06937645","the Effect of Hyaluronic Acid Intrauterine Wash on Endometrial Receptivity and Pregnancy Outcome","the Effect of Hyaluronic Acid Platelets Rich Plasma on the Endometrial Receptivity and Intracytoplasmic Sperms Injection Outcome","Inclusion Criteria:\n\n* Infertile females aged 18-40 years.\n* Infertile females scheduled for GnRH antagonist protocol of fresh ICSI cycle.\n* Females use dual stimulation (GnRH agonist plus Ovetrelle) for ovulation triggering.\n\nExclusion Criteria:\n\n* Infertile females diagnosed as a poor responder.\n* Infertile females diagnosed with uterine pathology.\n* Infertile females who are scheduled for a frozen ICSI cycle.\n* Infertile females diagnosed with endocrine diseases like thyroid disease, diabetes mellitus, and hyperprolactinemia.\n* Infertile females diagnosed with thrombocytopenia.","FEMALE","18 Years","40 Years",{"count":97,"type":98},120,"ESTIMATED","INTERVENTIONAL",[101],"PHASE2","Hyaluronic acid intrauterine wash is done for infertile females undergoing intracytoplasmic sperm injection on the day of oocyte retrieval. endometrial receptivity parameters, including the subendometrial vasculature indices were measured before and after the intervention for purpose of studying the effect of hyaluronic acid on improvement of the endometrial receptivity and subsequently the pregnancy outcome",[104],"Infertile Patients",[106,107,108,109],"hyaluronic acid","intrauterine wash","endometrial receptivity","pregnancy outcome","2025-04-18",{"date":112,"type":113},"2025-04-22","ACTUAL",{"date":115,"type":113},"2023-09-01",{"date":117,"type":98},"2025-08-01",{"name":5,"class":6},1]