[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100550734":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":28,"centralContacts":32,"locations":38,"responsibleParty":81,"collaborators":25,"id":83,"slug":25,"hasResults":84,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":25,"eligibilityCriteria":88,"healthyVolunteers":84,"sex":89,"minAge":25,"maxAge":25,"enrollmentInfo":90,"targetDuration":25,"studyType":93,"phases":94,"briefSummary":96,"conditions":97,"keywords":25,"overallStatus":41,"whyStopped":25,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},{"fullName":5,"class":6},"Children's Hospital Medical Center, Cincinnati","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Vitamin A","ACTIVE_COMPARATOR","Route of administration: Oral. Frequency: Once. Timing: Pre-transplant Dose of Vit A: 1.2 mg\u002Fkg, max dose 75 mg Formulation of Vit A: 2.5 mg liquid filled oral capsules.\n\nVitamin A level assessment: Vitamin A levels will be measured pre-transplant and again at day +30 (± 10 days)",[13],"Drug: Vitamin A",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo","PLACEBO_COMPARATOR","Placebo pills containing microcrystalline cellulose will be dispensed in patients who are randomized to the placebo arm.",[19],"Other: Placebo",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Enrolled subjects will receive one observed oral vitamin A dose, prior to their HSCT, in the outpatient clinic or inpatient Bone Marrow Transplant (BMT) floor.",[9],null,{"type":6,"name":15,"description":17,"armGroupLabels":27,"otherNames":25},[15],[29],{"name":30,"affiliation":5,"role":31},"Pooja Khandelwal, MD","PRINCIPAL_INVESTIGATOR",[33],{"name":34,"role":35,"phone":36,"phoneExt":25,"email":37},"Celeste Dourson, MS, CCRP","CONTACT","513-636-7679","celeste.dourson@cchmc.org",[39,55,68],{"facility":40,"status":41,"city":42,"state":43,"zip":44,"country":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Moffitt Cancer Center","RECRUITING","Tampa","Florida","33612","United States",{"type":47,"coordinates":48},"Point",[49,50],-82.45843,27.94752,{"lat":50,"lon":49},[53],{"name":54,"role":31,"phone":25,"phoneExt":25,"email":25},"Nelli Bejanyan, MD",{"facility":56,"status":41,"city":57,"state":58,"zip":59,"country":45,"cosmosGeoPoint":60,"geoPoint":64,"contacts":65},"Roswell Park Comprehensive Cancer Center","Buffalo","New York","14203",{"type":47,"coordinates":61},[62,63],-78.87837,42.88645,{"lat":63,"lon":62},[66],{"name":67,"role":31,"phone":25,"phoneExt":25,"email":25},"Theresa Hahn, PhD",{"facility":69,"status":41,"city":70,"state":71,"zip":72,"country":45,"cosmosGeoPoint":73,"geoPoint":77,"contacts":78},"The Ohio State University","Columbus","Ohio","43210",{"type":47,"coordinates":74},[75,76],-82.99879,39.96118,{"lat":76,"lon":75},[79],{"name":80,"role":31,"phone":25,"phoneExt":25,"email":25},"Sumithira Vasu, MD",{"type":82,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100550734",false,"NCT06450925","Vitamin A Supplementation in Allogeneic Stem Cell Transplantation.","A Randomized Double Blinded Trial of Vitamin A Supplementation in Allogeneic Stem Cell Transplantation.","Inclusion Criteria:\n\n* Be 18 years of age or older\n* Be scheduled for allogeneic stem cell transplant.\n* Have a vitamin A level \\\u003C upper limit of normal for age.\n* Be able to tolerate enteral vitamin dose administration.\n* Have a total bilirubin level \\\u003C 1.5x ULN and an AST and\u002For ALT\\\u003C 3xULN for age\n* Receiving PBSCs as stem cell graft\n\nExclusion Criteria:\n\n* Ongoing raised intracranial pressure\n* Liver cirrhosis\n* Patients will be excluded if they are currently pregnant.","ALL",{"count":91,"type":92},190,"ESTIMATED","INTERVENTIONAL",[95],"PHASE2","The investigators hypothesize that single oral high dose supplementation with vitamin A will reduce the incidence of moderate-severe chronic graft-versus-host disease (GVHD) compared with placebo.",[98,99,100],"Graft Vs Host Disease","Vitamin A Deficiency","Vitamin D Deficiency","2025-08-11",{"date":103,"type":104},"2025-08-12","ACTUAL",{"date":106,"type":104},"2025-03-25",{"date":108,"type":92},"2029-08",{"name":5,"class":6},3]