This study will investigate how different types of routine sedation may affect patient's breathing whilst on a ventilator in the Intensive Care Unit (ICU). There are different approaches to sedation which may have advantages and disadvantages. During the study patients will receive both intravenous and inhaled volatile sedation (similar to anaesthetic 'gases' used for general anaesthesia) and the drive to breath, breathing efforts and function of the lung will be assessed.
Adult patients admitted to the Intensive Care Unit (ICU)
ARDS
Invasive mechanical ventilation (IMV)
Spontaneous breathing in pressures support mode (PSV) for less than or equal to 48 hours
Personal or family history of malignant hyperpyrexia
Known or suspected elevated intracranial pressure
High dose vasopressors (ie. Noradrenaline > 0.3mcg/kg/min or equivalent)
Contra-indication to oesophageal balloon (i.e. oesophageal / upper gastro-intestinal pathology)
Guy's and St Thomas' NHS Foundation Trust
Lead sponsor
Sedana Medical
Collaborator