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8YA",{"type":84,"coordinates":799},[800,801],-2.97794,53.41058,{"lat":801,"lon":800},{"facility":804,"status":77,"city":805,"state":11,"zip":806,"country":778,"countryCode":779,"cosmosGeoPoint":807,"geoPoint":811,"contacts":11},"Exelixis Clinical Site #33","Sheffield","S10 2SJ",{"type":84,"coordinates":808},[809,810],-1.4659,53.38297,{"lat":810,"lon":809},{"type":813,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100588619",false,"NCT06943755","Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors","A Phase 2\u002F3, Multicenter, Randomized Open-Label Study of Zanzalintinib vs Everolimus in Participants With Previously Treated, Unresectable, Locally Advanced or Metastatic Neuroendocrine Tumors","STELLAR-311","Key Inclusion Criteria:\n\n* Histologically confirmed, locally advanced\u002Funresectable or metastatic, well-differentiated Grade 1, 2, or 3 NETs of pancreatic origin or extra-pancreatic origin.\n* Allowed prior lines of therapy, based on the site of NET and functional status.\n* Documented radiographic disease progression per RECIST 1.1, as assessed by the Investigator based on imaging assessments (computed tomography \\[CT\\] or magnetic resonance imaging \\[MRI\\]) within 12 months before randomization.\n* Measurable disease according to RECIST 1.1 as determined by the Investigator.\n* Archival tumor tissue is required, if available. If archival tumor tissue is not available, a fresh biopsy may be submitted if it can be safely and feasibly obtained. Every attempt should be made to provide tumor tissue.\n\nKey Exclusion Criteria:\n\n* Histologically confirmed neuroendocrine carcinomas (including small cell lung cancer), medullary thyroid cancer, pheochromocytoma, paraganglioma, Merkel cell carcinoma, and mixed neuroendocrine non-neuroendocrine neoplasm (MiNEN).\n* Prior treatment with a vascular endothelial growth factor receptor (VEGFR) -targeting tyrosine kinase inhibitor or a mammalian target of rapamycin (mTOR) inhibitor.\n* Systemic chemotherapy and any liver-directed or other ablative therapy within 4 weeks before randomization.\n* Systemic radionuclide therapy within 6 weeks before randomization.\n* Radiation therapy for bone metastases within 2 weeks, any other radiation therapy, except as indicated above, within 4 weeks before randomization.\n\nNote: Other protocol defined Inclusion\u002FExclusion criteria may apply.","ALL","18 Years",{"count":824,"type":825},440,"ESTIMATED","INTERVENTIONAL",[828,829],"PHASE2","PHASE3","The primary purpose of this study is to assess the effectiveness of zanzalintinib compared to everolimus in participants with previously treated, unresectable, locally advanced or metastatic neuroendocrine tumors.",[832,833],"Pancreatic Neuroendocrine Tumor (pNET)","Extra-Pancreatic Neuroendocrine Tumor (epNET)",[835,836,837],"Metastatic Cancer","Locally Advanced Cancer","Neuroendocrine Tumor (NET)","2026-04-15",{"date":840,"type":841},"2026-04-17","ACTUAL",{"date":843,"type":841},"2025-07-21",{"date":845,"type":825},"2029-06",{"name":5,"class":6},80]