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Branch","Taipei","10449",{"type":64,"coordinates":1319},[1320,1321],121.52639,25.05306,{"lat":1321,"lon":1320},{"facility":1324,"status":58,"city":1316,"state":11,"zip":1325,"country":1287,"cosmosGeoPoint":1326,"geoPoint":1328,"contacts":11},"Taipei Veterans General Hospital","11217",{"type":64,"coordinates":1327},[1320,1321],{"lat":1321,"lon":1320},{"facility":1330,"status":58,"city":1331,"state":11,"zip":1332,"country":1333,"cosmosGeoPoint":1334,"geoPoint":1338,"contacts":11},"Baskent University Adana Application and Research Center","Adana","01120","Turkey (Türkiye)",{"type":64,"coordinates":1335},[1336,1337],35.32531,36.98615,{"lat":1337,"lon":1336},{"facility":1340,"status":58,"city":1341,"state":11,"zip":1342,"country":1333,"cosmosGeoPoint":1343,"geoPoint":1347,"contacts":11},"Dr. Abdurrahman Yurtaslan Oncology Teaching and Research Hospital","Ankara","06200",{"type":64,"coordinates":1344},[1345,1346],32.85427,39.91987,{"lat":1346,"lon":1345},{"facility":1349,"status":58,"city":1341,"state":11,"zip":1350,"country":1333,"cosmosGeoPoint":1351,"geoPoint":1353,"contacts":11},"Hacettepe University","06230",{"type":64,"coordinates":1352},[1345,1346],{"lat":1346,"lon":1345},{"facility":1355,"status":58,"city":1341,"state":11,"zip":1356,"country":1333,"cosmosGeoPoint":1357,"geoPoint":1359,"contacts":11},"Baskent University Ankara Hospital","06490",{"type":64,"coordinates":1358},[1345,1346],{"lat":1346,"lon":1345},{"facility":1361,"status":58,"city":1362,"state":11,"zip":1363,"country":1333,"cosmosGeoPoint":1364,"geoPoint":1368,"contacts":11},"İzmir City Hospital","Bayraklı","35540",{"type":64,"coordinates":1365},[1366,1367],41.18253,37.99375,{"lat":1367,"lon":1366},{"facility":1370,"status":58,"city":1371,"state":11,"zip":1372,"country":1333,"cosmosGeoPoint":1373,"geoPoint":1377,"contacts":11},"Bezmialem Vakif Universitesi Tip Fakultesi Hastanesi","Istanbul","34093",{"type":64,"coordinates":1374},[1375,1376],28.94966,41.01384,{"lat":1376,"lon":1375},{"facility":1379,"status":58,"city":1380,"state":11,"zip":1381,"country":1382,"cosmosGeoPoint":1383,"geoPoint":1387,"contacts":11},"Royal Sussex County Hospital","Brighton","BN2 1ES","United Kingdom",{"type":64,"coordinates":1384},[1385,1386],-0.13947,50.82838,{"lat":1386,"lon":1385},{"facility":1389,"status":58,"city":1390,"state":11,"zip":1391,"country":1382,"cosmosGeoPoint":1392,"geoPoint":1396,"contacts":11},"Bristol Haematology and Oncology Centre","Bristol","BS2 8ED",{"type":64,"coordinates":1393},[1394,1395],-2.59665,51.45523,{"lat":1395,"lon":1394},{"facility":1398,"status":58,"city":1399,"state":11,"zip":1400,"country":1382,"cosmosGeoPoint":1401,"geoPoint":1405,"contacts":11},"Addenbrooke's Hospital","Cambridge","CB2 0QQ",{"type":64,"coordinates":1402},[1403,1404],0.11667,52.2,{"lat":1404,"lon":1403},{"facility":1407,"status":58,"city":1408,"state":11,"zip":1409,"country":1382,"cosmosGeoPoint":1410,"geoPoint":1414,"contacts":11},"Castle Hill Hospital","Cottingham","HU165JQ",{"type":64,"coordinates":1411},[1412,1413],-0.7554,52.50243,{"lat":1413,"lon":1412},{"facility":1416,"status":58,"city":1417,"state":11,"zip":1418,"country":1382,"cosmosGeoPoint":1419,"geoPoint":1423,"contacts":11},"Western General Hospital","Edinburgh","EH4 2XU",{"type":64,"coordinates":1420},[1421,1422],-3.19648,55.95206,{"lat":1422,"lon":1421},{"facility":1425,"status":58,"city":1426,"state":11,"zip":1427,"country":1382,"cosmosGeoPoint":1428,"geoPoint":1432,"contacts":11},"Royal Devon & Exeter HPT","Exeter","EX2 5DW",{"type":64,"coordinates":1429},[1430,1431],-3.52751,50.7236,{"lat":1431,"lon":1430},{"facility":1434,"status":58,"city":1435,"state":11,"zip":1436,"country":1382,"cosmosGeoPoint":1437,"geoPoint":1441,"contacts":11},"University College London Hospitals","London","NW1 2PG",{"type":64,"coordinates":1438},[1439,1440],-0.12574,51.50853,{"lat":1440,"lon":1439},{"facility":1443,"status":58,"city":1435,"state":11,"zip":1444,"country":1382,"cosmosGeoPoint":1445,"geoPoint":1447,"contacts":11},"Guy's Hospital","SE1 9RT",{"type":64,"coordinates":1446},[1439,1440],{"lat":1440,"lon":1439},{"facility":1449,"status":58,"city":1450,"state":11,"zip":1451,"country":1382,"cosmosGeoPoint":1452,"geoPoint":1456,"contacts":11},"Mount Vermont Cancer Center","Middlesex","HA6 2RN",{"type":64,"coordinates":1453},[1454,1455],-0.26856,51.53174,{"lat":1455,"lon":1454},{"facility":1458,"status":58,"city":1459,"state":11,"zip":1460,"country":1382,"cosmosGeoPoint":1461,"geoPoint":1465,"contacts":11},"Nottingham University Hospitals NHS Trust","Nottingham","NG5 1PB",{"type":64,"coordinates":1462},[1463,1464],-1.15047,52.9536,{"lat":1464,"lon":1463},{"facility":1467,"status":58,"city":1468,"state":11,"zip":1469,"country":1382,"cosmosGeoPoint":1470,"geoPoint":1474,"contacts":11},"Singleton Hospital","Swansea","SA2 8QA",{"type":64,"coordinates":1471},[1472,1473],-3.94323,51.62079,{"lat":1473,"lon":1472},{"facility":1476,"status":58,"city":1477,"state":11,"zip":1478,"country":1382,"cosmosGeoPoint":1479,"geoPoint":1483,"contacts":11},"Royal Cornwall Hospital","Truro","TR1 3LJ",{"type":64,"coordinates":1480},[1481,1482],-5.05436,50.26526,{"lat":1482,"lon":1481},{"type":1485,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR",[1487,1489],{"name":1488,"class":6},"DualityBio Inc.",{"name":1490,"class":6},"BioNTech (Shanghai) Pharmaceuticals Co., Ltd.","100542261",false,"NCT06340568","A Clinical Study of the Anti-cancer Effects of an Investigational Therapy or Chemotherapy in Patients With Recurring Uterine Cancer","A Phase III, Randomized, Multi-site, Open-label Trial of BNT323\u002FDB-1303 Versus Investigator's Choice of Chemotherapy in Previously Treated Patients With HER2- Expressing Recurrent Endometrial Cancer","Fern-EC-01","Key Inclusion Criteria:\n\n* Are female adults (defined as ≥18 years of age or acceptable age according to local regulations at the time of voluntarily giving informed consent).\n* Have histologically confirmed endometrial cancer that:\n\n  * Is recurrent,\n  * Has a HER2 IHC score of 1+, 2+ (Cohort 1), or 3+ (Cohort 2) as determined by central laboratory testing for HER2 expression, and\n  * Is not defined as a true sarcoma (i.e., leiomyosarcoma or endometrial stromal sarcoma). Note: Uterine carcinosarcoma is allowed.\n* Have measurable disease defined by RECIST v1.1.\n* Have Eastern Cooperative Oncology Group (ECOG) Performance Status of 0, 1 or 2.\n* Have recurrent endometrial cancer and meet any of the following:\n\n  * developed recurrence \\\u003C12 months from completing platinum-based chemotherapy given as adjuvant therapy for Stage I to III disease, or\n  * developed recurrence after platinum-based chemotherapy in the recurrent\u002Fmetastatic setting.\n* Have received prior ICI treatment (i.e., anti-programmed death 1\u002Fanti-programmed death-ligand 1)\n* Have a life expectancy of ≥12 weeks at screening.\n\nKey Exclusion Criteria:\n\n* Are ineligible for all options in the investigator's choice of chemotherapy arm, per local prescribing information and institutional guidelines (applicable to Cohort 1 only).\n* Have a history of small bowel obstruction requiring hospitalization within the past 3 months prior the first dose of study treatment.\n* Have an uncontrolled intercurrent illness that would limit compliance with study requirement or substantially increase risk of incurring adverse events.\n* Have clinically uncontrolled pleural effusion, ascites or pericardial effusion requiring drainage, or peritoneal shunt within 2 weeks prior to the first dose of study treatment.\n* Have a history of (non-infectious) interstitial lung disease (ILD)\u002Fpneumonitis that required steroids, have current ILD\u002Fpneumonitis, or where suspected ILD\u002Fpneumonitis cannot be ruled out by imaging at screening.\n* Participants with prior use of immunosuppressive medication within 14 days prior to the first dose of study treatment, except for intranasal and inhaled corticosteroids or systemic corticosteroids at doses of less than 10 mg\u002Fday of prednisone or equivalent, and topical corticosteroids. Participants receiving corticosteroids may continue if the dose is stable upon giving main informed consent.\n* Have a lung-specific intercurrent clinically significant illness including, but not limited to, any underlying pulmonary disorder (e.g., pulmonary emboli within 3 months prior to the first dose of study treatment, severe asthma, chronic obstructive pulmonary disorder with moderate acute exacerbations, restrictive lung disease, pulmonary fibrosis, radiation pneumonitis, significant pleural effusion etc.), or any autoimmune, connective tissue or inflammatory disorder with pulmonary involvement (i.e., rheumatoid arthritis, Sjogren's syndrome, sarcoidosis etc.), and\u002For prior pneumonectomy (complete).\n* Have uncontrolled infection requiring systemic antibiotics, antivirals, or antifungals within 2 weeks prior to the first dose of study treatment.\n* Have unresolved toxicities from previous anti-cancer therapy, defined as toxicities (other than alopecia, fatigue, or endocrinopathies that are well controlled) not yet resolved to Grade ≤1 or baseline.\n* Are pregnant or breastfeeding or are planning pregnancy during the study or within 7 months after the last dose of study treatment.\n* Have a history of allergies, hypersensitivities, or intolerance to study treatments (investigational medicinal products and auxiliary medicinal product) including any excipients thereof or to other monoclonal antibodies. Participants who have successfully undergone a desensitization process and are able to tolerate the drug are eligible.\n* Had prior treatment with topoisomerase I inhibitors, including ADCs.\n* Have left ventricular ejection fraction \\\u003C55% by either echocardiography or multiple-gated acquisition within 28 days prior to the first dose of study treatment. This includes participants with tissue doppler E\u002Fe' ratio \\>15.\n\nNOTE: Other protocol defined Inclusion\u002FExclusion criteria apply.","FEMALE","18 Years",{"count":1501,"type":1502},480,"ESTIMATED","INTERVENTIONAL",[1505],"PHASE3","The study is divided into two cohorts (Cohort 1 and Cohort 2), to which participants will be enrolled based on the amount of human epidermal growth factor receptor 2 (HER2) in their tumor sample.\n\nIn Cohort 1, the main goal is to assess how well BNT323 (also known as DB-1303) or chemotherapy (doxorubicin or paclitaxel \\[or docetaxel, if participants cannot take paclitaxel\\]) works by determining the progression-free survival (PFS) of participants who have been previously treated with immune checkpoint inhibitors (ICIs).\n\nIn Cohort 2, the main goal is to assess how well BNT323 works by determining the objective response rate (ORR), that is, the percentage of participants whose tumor shrinks (partial response) or disappears (complete response) after treatment.\n\nThe safety of BNT323 will also be assessed by following the occurrence of unfavorable\u002Fadverse effects that are seen after treatment. Other measures include the pharmacokinetics of BNT323 (or how BNT323 moves through and out of the body), the body's immune response, and the impact on quality of life.",[1508],"Endometrial Cancer",[1510,1511,1512,1513,1514,1515,1516,1517,1518,1519],"Human epidermal growth factor receptor 2 (HER2)","HER2-expressing tumors","Recurrent endometrial cancer","IHC scores 1+, 2+, and 3+","Immune checkpoint inhibitor","Platinum-based therapy","HER2 protein expression","HER2-expressing endometrial cancer","ErbB-2 receptor","Antibody drug conjugate (ADC)","2026-06-29",{"date":1522,"type":1523},"2026-06-30","ACTUAL",{"date":1525,"type":1523},"2025-06-10",{"date":1527,"type":1502},"2029-11",{"name":5,"class":6},163]