[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100641561":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":29,"centralContacts":37,"locations":43,"responsibleParty":438,"collaborators":29,"id":440,"slug":29,"hasResults":441,"nctId":442,"briefTitle":443,"officialTitle":444,"acronym":29,"eligibilityCriteria":445,"healthyVolunteers":441,"sex":446,"minAge":447,"maxAge":448,"enrollmentInfo":449,"targetDuration":29,"studyType":452,"phases":453,"briefSummary":455,"conditions":456,"keywords":29,"overallStatus":59,"whyStopped":29,"lastUpdateSubmitDate":458,"lastUpdatePostDateStruct":459,"startDateStruct":462,"completionDateStruct":464,"leadSponsor":466,"locationsCount":467},{"fullName":5,"class":6},"Definium Therapeutics US, Inc.","INDUSTRY",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Arm 1 - Placebo","PLACEBO_COMPARATOR","A substance that is designed to have no therapeutic value",[13],"Other: Placebo",{"label":15,"type":16,"description":17,"interventionNames":18},"Arm 2 - 50µg DT120","SHAM_COMPARATOR","A psychoactive substance that mediates effects mainly through an agonist activity in the serotonin 2A receptor (5-HT2A)",[19],"Drug: DT120",{"label":21,"type":22,"description":17,"interventionNames":23},"Arm 3 - 100µg DT120","EXPERIMENTAL",[19],[25,30],{"type":26,"name":27,"description":11,"armGroupLabels":28,"otherNames":29},"OTHER","Placebo",[9],null,{"type":31,"name":32,"description":17,"armGroupLabels":33,"otherNames":34},"DRUG","DT120",[15,21],[35,36],"MM120","lysergide tartrate",[38],{"name":39,"role":40,"phone":41,"phoneExt":29,"email":42},"Definium Therapeutics Clinical Trials Info Requests","CONTACT","1-332-282-0479","clinicaltrials@definiumtx.com",[44,57,74,90,104,118,133,148,162,176,191,205,219,235,250,261,275,290,305,319,334,349,364,379,394,408,424],{"facility":45,"status":46,"city":47,"state":48,"zip":49,"country":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":29},"Lighthouse Psychiatry","WITHDRAWN","Gilbert","Arizona","85234","United States",{"type":52,"coordinates":53},"Point",[54,55],-111.78903,33.35283,{"lat":55,"lon":54},{"facility":58,"status":59,"city":60,"state":61,"zip":62,"country":50,"cosmosGeoPoint":63,"geoPoint":67,"contacts":68},"Preferred Research Partners, Inc.","RECRUITING","Little Rock","Arkansas","72211",{"type":52,"coordinates":64},[65,66],-92.28959,34.74648,{"lat":66,"lon":65},[69],{"name":70,"role":40,"phone":71,"phoneExt":72,"email":73},"Stacy Tierney","501-553-9987","x111","stierney@preferredresearchpartners.com",{"facility":75,"status":76,"city":77,"state":78,"zip":79,"country":50,"cosmosGeoPoint":80,"geoPoint":84,"contacts":85},"Kadima Neuropsychiatry Institute","NOT_YET_RECRUITING","San Diego","California","92037",{"type":52,"coordinates":81},[82,83],-117.16472,32.71571,{"lat":83,"lon":82},[86],{"name":87,"role":40,"phone":88,"phoneExt":29,"email":89},"Alexiss Rivas","858-412-4130","alexissr@kadimanp.com",{"facility":91,"status":76,"city":92,"state":78,"zip":93,"country":50,"cosmosGeoPoint":94,"geoPoint":98,"contacts":99},"UCSF Department of Neurology","San Francisco","94158",{"type":52,"coordinates":95},[96,97],-122.41942,37.77493,{"lat":97,"lon":96},[100],{"name":101,"role":40,"phone":102,"phoneExt":29,"email":103},"Jennifer Mitchell","510-985-3522","LSDForDepression@ucsf.edu",{"facility":105,"status":59,"city":106,"state":78,"zip":107,"country":50,"cosmosGeoPoint":108,"geoPoint":112,"contacts":113},"Psychedelic Science Institute","Santa Monica","90404",{"type":52,"coordinates":109},[110,111],-118.49138,34.01949,{"lat":111,"lon":110},[114],{"name":115,"role":40,"phone":116,"phoneExt":29,"email":117},"Ashley Ramos","310-341-2882","aramos@psychedelicsci.com",{"facility":119,"status":59,"city":120,"state":121,"zip":122,"country":50,"cosmosGeoPoint":123,"geoPoint":127,"contacts":128},"Mountain View Clinical Research, Inc","Denver","Colorado","80209",{"type":52,"coordinates":124},[125,126],-104.9847,39.73915,{"lat":126,"lon":125},[129],{"name":130,"role":40,"phone":131,"phoneExt":29,"email":132},"Jessica Bryant","720-941-8894","jessica@mtnresearch.com",{"facility":134,"status":76,"city":135,"state":136,"zip":137,"country":50,"cosmosGeoPoint":138,"geoPoint":142,"contacts":143},"K2 Medical Research (Maitland)","Maitland","Florida","32751",{"type":52,"coordinates":139},[140,141],-81.36312,28.62778,{"lat":141,"lon":140},[144],{"name":145,"role":40,"phone":146,"phoneExt":29,"email":147},"Vanessa Carrillo","407-676-5252","vanessa.carrillo@k2med.com",{"facility":149,"status":76,"city":150,"state":136,"zip":151,"country":50,"cosmosGeoPoint":152,"geoPoint":156,"contacts":157},"Charter Research","Orlando","32803",{"type":52,"coordinates":153},[154,155],-81.37924,28.53834,{"lat":155,"lon":154},[158],{"name":159,"role":40,"phone":160,"phoneExt":29,"email":161},"Sarahi Monsalve","407-337-1000","sarahi.monsalve@charterresearch.com",{"facility":163,"status":76,"city":164,"state":136,"zip":165,"country":50,"cosmosGeoPoint":166,"geoPoint":170,"contacts":171},"K2 Medical Research (Tampa)","Tampa","33607",{"type":52,"coordinates":167},[168,169],-82.45843,27.94752,{"lat":169,"lon":168},[172],{"name":173,"role":40,"phone":174,"phoneExt":29,"email":175},"Karina Perez","813-800-5252","karina.perez@k2med.com",{"facility":177,"status":59,"city":178,"state":179,"zip":180,"country":50,"cosmosGeoPoint":181,"geoPoint":185,"contacts":186},"CenExel Atlanta","Atlanta","Georgia","30331",{"type":52,"coordinates":182},[183,184],-84.38798,33.749,{"lat":184,"lon":183},[187],{"name":188,"role":40,"phone":189,"phoneExt":29,"email":190},"Denniel Brown","404-881-5800","d.brown@cenexel.com",{"facility":192,"status":59,"city":193,"state":179,"zip":194,"country":50,"cosmosGeoPoint":195,"geoPoint":199,"contacts":200},"CenExel Decatur","Decatur","30030",{"type":52,"coordinates":196},[197,198],-84.29631,33.77483,{"lat":198,"lon":197},[201],{"name":202,"role":40,"phone":203,"phoneExt":29,"email":204},"Branden Freeman","404-537-1281","b.freeman@cenexel.com",{"facility":206,"status":59,"city":207,"state":179,"zip":208,"country":50,"cosmosGeoPoint":209,"geoPoint":213,"contacts":214},"CenExel Savannah","Savannah","31405",{"type":52,"coordinates":210},[211,212],-81.09983,32.08354,{"lat":212,"lon":211},[215],{"name":216,"role":40,"phone":217,"phoneExt":29,"email":218},"Katie McCants","912-744-0800","k.mccants@cenexel.com",{"facility":220,"status":59,"city":221,"state":222,"zip":223,"country":50,"cosmosGeoPoint":224,"geoPoint":228,"contacts":229},"Uptown Research Institute","Chicago","Illinois","60640",{"type":52,"coordinates":225},[226,227],-87.65005,41.85003,{"lat":227,"lon":226},[230],{"name":231,"role":40,"phone":232,"phoneExt":233,"email":234},"Chloe Rzeppa","773-989-8313","x113","crzeppa@uptownresearch.com",{"facility":236,"status":59,"city":237,"state":238,"zip":239,"country":50,"cosmosGeoPoint":240,"geoPoint":244,"contacts":245},"Adams Clinical Boston","Boston","Massachusetts","02116",{"type":52,"coordinates":241},[242,243],-71.05977,42.35843,{"lat":243,"lon":242},[246],{"name":247,"role":40,"phone":248,"phoneExt":29,"email":249},"Anotida Viazhero","617-934-5743","aviazhero@adamsclinical.com",{"facility":251,"status":59,"city":237,"state":238,"zip":252,"country":50,"cosmosGeoPoint":253,"geoPoint":255,"contacts":256},"Adams Clinical","02472",{"type":52,"coordinates":254},[242,243],{"lat":243,"lon":242},[257],{"name":258,"role":40,"phone":259,"phoneExt":29,"email":260},"Harrison Gillman","617-744-8542","hgillman@adamsclinical.com",{"facility":262,"status":76,"city":263,"state":238,"zip":264,"country":50,"cosmosGeoPoint":265,"geoPoint":269,"contacts":270},"Vitalix Clinical","Worcester","01608",{"type":52,"coordinates":266},[267,268],-71.80229,42.26259,{"lat":268,"lon":267},[271],{"name":272,"role":40,"phone":273,"phoneExt":29,"email":274},"Rajvi Patel","413-363-5206","rpatel@vitalixclinical.com",{"facility":276,"status":76,"city":277,"state":278,"zip":279,"country":50,"cosmosGeoPoint":280,"geoPoint":284,"contacts":285},"Arch Clinical Trials, LLC","St Louis","Missouri","63141",{"type":52,"coordinates":281},[282,283],-90.19789,38.62727,{"lat":283,"lon":282},[286],{"name":287,"role":40,"phone":288,"phoneExt":29,"email":289},"Erica Ehrhardt","314-282-3521","eehrhardt@archclinicaltrials.com",{"facility":291,"status":76,"city":292,"state":293,"zip":294,"country":50,"cosmosGeoPoint":295,"geoPoint":299,"contacts":300},"Redbird Research","Las Vegas","Nevada","89119",{"type":52,"coordinates":296},[297,298],-115.13722,36.17497,{"lat":298,"lon":297},[301],{"name":302,"role":40,"phone":303,"phoneExt":29,"email":304},"Pam Pioquinto","702-577-2000","pamela@redbird-research.com",{"facility":306,"status":59,"city":307,"state":307,"zip":308,"country":50,"cosmosGeoPoint":309,"geoPoint":313,"contacts":314},"Adams Clinical Harlem","New York","10029",{"type":52,"coordinates":310},[311,312],-74.00597,40.71427,{"lat":312,"lon":311},[315],{"name":316,"role":40,"phone":317,"phoneExt":29,"email":318},"Ashli Pratt","917-423-6797","apratt@adamsclinical.com",{"facility":320,"status":76,"city":321,"state":322,"zip":323,"country":50,"cosmosGeoPoint":324,"geoPoint":328,"contacts":329},"Cleveland Clinic","Cleveland","Ohio","44113",{"type":52,"coordinates":325},[326,327],-81.69541,41.4995,{"lat":327,"lon":326},[330],{"name":331,"role":40,"phone":332,"phoneExt":29,"email":333},"Katelyn Schwesinger","440-728-6025","schwesk@ccf.org",{"facility":335,"status":59,"city":336,"state":337,"zip":338,"country":50,"cosmosGeoPoint":339,"geoPoint":343,"contacts":344},"Adams Clinical Philadelphia","Philadelphia","Pennsylvania","19104",{"type":52,"coordinates":340},[341,342],-75.16362,39.95238,{"lat":342,"lon":341},[345],{"name":346,"role":40,"phone":347,"phoneExt":29,"email":348},"Elizabeth Huang","267-207-2511","ehuang@adamsclinical.com",{"facility":350,"status":59,"city":351,"state":352,"zip":353,"country":50,"cosmosGeoPoint":354,"geoPoint":358,"contacts":359},"Coastal Carolina Research","North Charleston","South Carolina","29405",{"type":52,"coordinates":355},[356,357],-79.97481,32.85462,{"lat":357,"lon":356},[360],{"name":361,"role":40,"phone":362,"phoneExt":29,"email":363},"Brandy Dreyer","843-856-3784","brandy.dreyer@coastalcarolinaresearch.com",{"facility":365,"status":76,"city":366,"state":367,"zip":368,"country":50,"cosmosGeoPoint":369,"geoPoint":373,"contacts":374},"Austin Clinical Trial Partners","Austin","Texas","78737",{"type":52,"coordinates":370},[371,372],-97.74306,30.26715,{"lat":372,"lon":371},[375],{"name":376,"role":40,"phone":377,"phoneExt":29,"email":378},"Cara Fonken","512-521-0595","cfonken@austinCTP.com",{"facility":380,"status":59,"city":381,"state":382,"zip":383,"country":50,"cosmosGeoPoint":384,"geoPoint":388,"contacts":389},"Cedar Clinical Research","Draper","Utah","84020",{"type":52,"coordinates":385},[386,387],-111.86382,40.52467,{"lat":387,"lon":386},[390],{"name":391,"role":40,"phone":392,"phoneExt":29,"email":393},"Kye Cutrubus","801-369-4219","kye.cutrubus@numinusnetwork.com",{"facility":395,"status":59,"city":396,"state":382,"zip":397,"country":50,"cosmosGeoPoint":398,"geoPoint":402,"contacts":403},"Inner Space Research","Orem","84058",{"type":52,"coordinates":399},[400,401],-111.69465,40.2969,{"lat":401,"lon":400},[404],{"name":405,"role":40,"phone":406,"phoneExt":29,"email":407},"Yohan Paitrault","801-871-5516","yohan@innerspaceresearch.com",{"facility":409,"status":76,"city":410,"state":411,"zip":412,"country":50,"cosmosGeoPoint":413,"geoPoint":417,"contacts":418},"Seattle Neuropsychiatric Treatment Center","Seattle","Washington","98104",{"type":52,"coordinates":414},[415,416],-122.33207,47.60621,{"lat":416,"lon":415},[419],{"name":420,"role":40,"phone":421,"phoneExt":422,"email":423},"Libby Kell","206-467-6300","5","libby.kell@seattlentc.com",{"facility":425,"status":76,"city":426,"state":411,"zip":427,"country":50,"cosmosGeoPoint":428,"geoPoint":432,"contacts":433},"VA Portland Healthcare System","Vancouver","98661",{"type":52,"coordinates":429},[430,431],-122.66149,45.63873,{"lat":431,"lon":430},[434],{"name":435,"role":40,"phone":436,"phoneExt":29,"email":437},"Bianca Watt","503-781-1205","bianca.watt@va.gov",{"type":439,"investigatorFullName":29,"investigatorTitle":29,"investigatorAffiliation":29,"oldNameTitle":29,"oldOrganization":29},"SPONSOR","100641561",false,"NCT07592689","A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)","A Phase 3 Multicenter, Randomized, Double-blind, Placebo-controlled, 12-Week Study (Part A) With a 40-Week Open-label Extension (Part B) Evaluating the Efficacy and Safety of Oral DT120 Compared to Placebo in the Treatment of Adults With Major Depressive Disorder - Ascend","Inclusion Criteria:\n\n1. Diagnosis of MDD per DSM-5\n2. Male or female aged 18 to 74\n3. Currently experiencing a major depressive episode (MDE) of ≥8 weeks and ≤24 months duration\n4. MADRS Total Score ≥26\n5. CGI-S Score ≥4\n\nExclusion Criteria:\n\n1. Certain psychiatric disorders (other than major depressive disorder)\n2. First degree relative with or lifetime history of a psychotic disorder or bipolar disorder\n3. Current diagnosis of alcohol or substance use disorder (excluding nicotine and caffeine\n4. Any clinically significant unstable illness","ALL","18 Years","74 Years",{"count":450,"type":451},165,"ESTIMATED","INTERVENTIONAL",[454],"PHASE3","A Phase 3 Double-blind, Placebo-controlled Study (Part A) with an Open-label Extension (Part B) Evaluating DT120 Compared to Placebo in Major Depressive Disorder - Ascend",[457],"Major Depressive Disorder","2026-06-26",{"date":460,"type":461},"2026-06-29","ACTUAL",{"date":463,"type":461},"2026-05-10",{"date":465,"type":451},"2028-06",{"name":5,"class":6},27]