[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100441314":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":28,"centralContacts":33,"locations":38,"responsibleParty":259,"collaborators":261,"id":265,"slug":11,"hasResults":266,"nctId":267,"briefTitle":268,"officialTitle":268,"acronym":11,"eligibilityCriteria":269,"healthyVolunteers":266,"sex":270,"minAge":271,"maxAge":272,"enrollmentInfo":273,"targetDuration":11,"studyType":276,"phases":277,"briefSummary":279,"conditions":280,"keywords":282,"overallStatus":40,"whyStopped":11,"lastUpdateSubmitDate":288,"lastUpdatePostDateStruct":289,"startDateStruct":292,"completionDateStruct":294,"leadSponsor":296,"locationsCount":297},{"fullName":5,"class":6},"University of Alabama at Birmingham","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Control Group","PLACEBO_COMPARATOR",null,[13],"Other: Control Group",{"label":15,"type":16,"description":11,"interventionNames":17},"AZM 20mg\u002Fkg Treatment Group","ACTIVE_COMPARATOR",[18],"Drug: AZM Group",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"DRUG","AZM Group","AZM at 20 mg\u002Fkg will be given intravenous daily for 3 days once patients are consented and enrolled into the study.",[15],{"type":6,"name":9,"description":26,"armGroupLabels":27,"otherNames":11},"Saline will be given intravenous daily for 3 days once patients are consented and enrolled into the study.",[9],[29],{"name":30,"affiliation":31,"role":32},"Michele Kong, MD","The University of Alabama at Birmingham","PRINCIPAL_INVESTIGATOR",[34],{"name":30,"role":35,"phone":36,"phoneExt":11,"email":37},"CONTACT","205-638-9387","mkong@uabmc.edu",[39,54,71,85,101,115,129,144,158,173,187,200,214,229,244],{"facility":31,"status":40,"city":41,"state":42,"zip":43,"country":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"RECRUITING","Birmingham","Alabama","35233","United States",{"type":46,"coordinates":47},"Point",[48,49],-86.80249,33.52066,{"lat":49,"lon":48},[52,53],{"name":30,"role":35,"phone":36,"phoneExt":11,"email":37},{"name":30,"role":32,"phone":11,"phoneExt":11,"email":11},{"facility":55,"status":40,"city":56,"state":57,"zip":58,"country":44,"cosmosGeoPoint":59,"geoPoint":63,"contacts":64},"University of California San Francisco","San Francisco","California","94143",{"type":46,"coordinates":60},[61,62],-122.41942,37.77493,{"lat":62,"lon":61},[65,68],{"name":66,"role":35,"phone":11,"phoneExt":11,"email":67},"Matt Zinter, MD","Matt.Zinter@ucsf.edu",{"name":69,"role":35,"phone":11,"phoneExt":11,"email":70},"James Howard, MD","James.Howard@ucsf.edu",{"facility":72,"status":40,"city":73,"state":74,"zip":75,"country":44,"cosmosGeoPoint":76,"geoPoint":80,"contacts":81},"Yale School of Medicine","New Haven","Connecticut","06520-8064",{"type":46,"coordinates":77},[78,79],-72.92816,41.30815,{"lat":79,"lon":78},[82],{"name":83,"role":35,"phone":11,"phoneExt":11,"email":84},"Vince Faustino, MD","vince.faustino@yale.edu",{"facility":86,"status":40,"city":87,"state":88,"zip":89,"country":44,"cosmosGeoPoint":90,"geoPoint":94,"contacts":95},"Children's National Hospital","Washington D.C.","District of Columbia","20010",{"type":46,"coordinates":91},[92,93],-77.03637,38.89511,{"lat":93,"lon":92},[96,99],{"name":97,"role":35,"phone":11,"phoneExt":11,"email":98},"Michael Shoykhet, MD","mshoykhet@childrensnational.org",{"name":97,"role":100,"phone":11,"phoneExt":11,"email":11},"SUB_INVESTIGATOR",{"facility":102,"status":40,"city":103,"state":104,"zip":105,"country":44,"cosmosGeoPoint":106,"geoPoint":110,"contacts":111},"Ann & Robert H. Lurie Children's Hospital of Chicago","Chicago","Illinois","60611",{"type":46,"coordinates":107},[108,109],-87.65005,41.85003,{"lat":109,"lon":108},[112],{"name":113,"role":35,"phone":11,"phoneExt":11,"email":114},"Bria Coates, MD","b-coates@northwestern.edu",{"facility":116,"status":40,"city":117,"state":118,"zip":119,"country":44,"cosmosGeoPoint":120,"geoPoint":124,"contacts":125},"Riley Children's Health","Indianapolis","Indiana","46202",{"type":46,"coordinates":121},[122,123],-86.15804,39.76838,{"lat":123,"lon":122},[126],{"name":127,"role":35,"phone":11,"phoneExt":11,"email":128},"Michael J Hobson, MD","mjhobson@iu.edu",{"facility":130,"status":40,"city":131,"state":132,"zip":133,"country":44,"cosmosGeoPoint":134,"geoPoint":138,"contacts":139},"St. Louis Children's Hospital","St Louis","Missouri","63110",{"type":46,"coordinates":135},[136,137],-90.19789,38.62727,{"lat":137,"lon":136},[140],{"name":141,"role":35,"phone":142,"phoneExt":11,"email":143},"Ashley Turner, MD","(314) 454-6000","ashley.turner@wustl.edu",{"facility":145,"status":40,"city":146,"state":147,"zip":148,"country":44,"cosmosGeoPoint":149,"geoPoint":153,"contacts":154},"University of Nebraska Medical Center","Omaha","Nebraska","68198",{"type":46,"coordinates":150},[151,152],-95.94043,41.25626,{"lat":152,"lon":151},[155],{"name":156,"role":35,"phone":11,"phoneExt":11,"email":157},"Eleanor Gradidge, MD","egradidge@childrensnebraska.org",{"facility":159,"status":40,"city":160,"state":161,"zip":162,"country":44,"cosmosGeoPoint":163,"geoPoint":167,"contacts":168},"University of North Carolina at Chapel Hill","Chapel Hill","North Carolina","27599",{"type":46,"coordinates":164},[165,166],-79.05584,35.9132,{"lat":166,"lon":165},[169],{"name":170,"role":35,"phone":171,"phoneExt":11,"email":172},"Tracie Walker, MD","9198431577","tracie_walker@med.unc.edu",{"facility":174,"status":40,"city":175,"state":176,"zip":177,"country":44,"cosmosGeoPoint":178,"geoPoint":182,"contacts":183},"Rainbow Babies and Children's Hospital","Cleveland","Ohio","44106",{"type":46,"coordinates":179},[180,181],-81.69541,41.4995,{"lat":181,"lon":180},[184],{"name":185,"role":35,"phone":11,"phoneExt":11,"email":186},"Steven Shein, MD","Steven.Shein@UHhospitals.org",{"facility":188,"status":40,"city":189,"state":176,"zip":190,"country":44,"cosmosGeoPoint":191,"geoPoint":195,"contacts":196},"Nationwide Children's Hospital","Columbus","43205",{"type":46,"coordinates":192},[193,194],-82.99879,39.96118,{"lat":194,"lon":193},[197],{"name":198,"role":35,"phone":11,"phoneExt":11,"email":199},"Katherine Bline, MD","katherine.bline@nationwidechildrens.org",{"facility":201,"status":40,"city":202,"state":203,"zip":204,"country":44,"cosmosGeoPoint":205,"geoPoint":209,"contacts":210},"Oklahoma Health Sciences","Oklahoma City","Oklahoma","73104",{"type":46,"coordinates":206},[207,208],-97.51643,35.46756,{"lat":208,"lon":207},[211],{"name":212,"role":35,"phone":11,"phoneExt":11,"email":213},"Christine Allen, MD","Christine-allen@ouhsc.edu",{"facility":215,"status":40,"city":216,"state":217,"zip":218,"country":44,"cosmosGeoPoint":219,"geoPoint":223,"contacts":224},"Children's Hospital of Philadelphia","Philadelphia","Pennsylvania","19104",{"type":46,"coordinates":220},[221,222],-75.16362,39.95238,{"lat":222,"lon":221},[225],{"name":226,"role":35,"phone":227,"phoneExt":11,"email":228},"Garrett Keim, MD","215-590-3800","keimG@chop.edu",{"facility":230,"status":40,"city":231,"state":232,"zip":233,"country":44,"cosmosGeoPoint":234,"geoPoint":238,"contacts":239},"The University of Texas Southwestern Medical Center","Dallas","Texas","75247",{"type":46,"coordinates":235},[236,237],-96.80667,32.78306,{"lat":237,"lon":236},[240],{"name":241,"role":35,"phone":242,"phoneExt":11,"email":243},"Ananya Manchikalapati, MD","2144561600","ananya.manchikalapati@UTsouthwestern.edu",{"facility":245,"status":40,"city":246,"state":247,"zip":248,"country":44,"cosmosGeoPoint":249,"geoPoint":253,"contacts":254},"University of Utah","Salt Lake City","Utah","84112",{"type":46,"coordinates":250},[251,252],-111.89105,40.76078,{"lat":252,"lon":251},[255],{"name":256,"role":35,"phone":257,"phoneExt":11,"email":258},"Kevin Watt, MD","801-587-7404","kevin.watt@hsc.utah.edu",{"type":32,"investigatorFullName":30,"investigatorTitle":260,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PI",[262],{"name":263,"class":264},"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","NIH","100441314",false,"NCT05026749","Azithromycin Treatment for Respiratory Syncytial Virus-induced Respiratory Failure in Children","Inclusion criteria:\n\n* Admission to the pediatric ICU with a confirmed diagnosis of RSV infection. RSV infection is based on a positive nasal swab for RSV fluorescent antibody or via multiplex assay or culture;\n* Requiring intensive respiratory support defined as either mechanical ventilation or NIV (BiPAP or CPAP) or HFNC (at \\>1 L\u002Fkg\u002Fmin of flow\n* Enrollment into the study within 48 hours of ICU admission and placement on intensive respiratory support;\n* Onset of RSV-related symptoms must be less than 5 days\n* Age: Neonates-2 years. For those less than 1 week of age, they must have been discharged home from the hospital after their birth.\n\nExclusion criteria:\n\n* AZM use within 7 days of ICU admission;\n* Contraindication to AZM use including known hypersensitivity to AZM, erythromycin, any macrolide, or ketolide drug, patients with significant hepatic impairment (direct bilirubin \\>1.5 mg\u002FdL or ALT ≥ 10 times the upper limits of normal);\n* Patients with known cardiac disease, cardiac arrhythmia or with electrocardiogram QT interval corrected for heart rate (QTc) ≥ 450 milisecond (ms);\n* Intensive respiratory support greater than 48 hours prior to ICU admission;\n* Chronic ventilation or supplemental oxygen need at home;\n* Immunosuppressive conditions such as those post heart or hematopoietic stem cell transplant or receiving chemotherapy and chronic steroids;\n* History of pyloric stenosis;\n* AZM is deemed necessary for clinical treatment (for instance, if patient has pertussis).","ALL","3 Days","2 Years",{"count":274,"type":275},370,"ESTIMATED","INTERVENTIONAL",[278],"PHASE3","The overarching hypothesis of the ARRC trial is that administration of Azithromycin (AZM) during acute, Respiratory Syncytial Virus (RSV)-induced respiratory failure will be beneficial, mediated through the matrix metalloproteinase (MMP)-9 pathway.",[281],"Respiratory Syncytial Virus Infections",[283,284,285,286,287],"RSV","AZM","ICU","Respiratory Support","Children","2026-02-04",{"date":290,"type":291},"2026-02-09","ACTUAL",{"date":293,"type":291},"2022-02-27",{"date":295,"type":275},"2028-07-31",{"name":5,"class":6},15]