[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636542":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":38,"locations":44,"responsibleParty":251,"collaborators":253,"id":257,"slug":26,"hasResults":258,"nctId":259,"briefTitle":260,"officialTitle":260,"acronym":261,"eligibilityCriteria":262,"healthyVolunteers":263,"sex":264,"minAge":265,"maxAge":266,"enrollmentInfo":267,"targetDuration":26,"studyType":270,"phases":271,"briefSummary":273,"conditions":274,"keywords":276,"overallStatus":80,"whyStopped":26,"lastUpdateSubmitDate":278,"lastUpdatePostDateStruct":279,"startDateStruct":282,"completionDateStruct":284,"leadSponsor":286,"locationsCount":287},{"fullName":5,"class":6},"Ohio State University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"0.05% Atropine","EXPERIMENTAL","0.05% atropine instilled in each eye nightly at bedtime",[13],"Drug: Atropine Sulfate 0.05% Oph Soln",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo","PLACEBO_COMPARATOR","Placebo drops instilled in each eye nightly at bedtime",[19],"Drug: Placebo",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Atropine Sulfate 0.05% Oph Soln","Atropine Sulfate 0.05% Oph Soln compounded at the pharmacy",[9],null,{"type":22,"name":15,"description":28,"armGroupLabels":29,"otherNames":26},"Placebo drop with same formulation as treatment minus the atropine",[15],[31,35],{"name":32,"affiliation":33,"role":34},"David A Berntsen, OD PhD","University of Houston College of Optometry","STUDY_CHAIR",{"name":36,"affiliation":37,"role":34},"Jeffrey J Walline, OD PhD","The Ohio State University College of Optometry",[39],{"name":40,"role":41,"phone":42,"phoneExt":26,"email":43},"Lisa A Jordan, PhD","CONTACT","614-247-7321","jordan.646@osu.edu",[45,63,78,93,107,122,137,152,166,181,194,208,223,237],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"University of Alabama School of Optometry","NOT_YET_RECRUITING","Birmingham","Alabama","35233","United States",{"type":53,"coordinates":54},"Point",[55,56],-86.80249,33.52066,{"lat":56,"lon":55},[59],{"name":60,"role":41,"phone":61,"phoneExt":26,"email":62},"Safal Khanal, OD PhD","205-934-4558","skhanal@uab.edu",{"facility":64,"status":47,"city":65,"state":66,"zip":67,"country":51,"cosmosGeoPoint":68,"geoPoint":72,"contacts":73},"University of California, Berkeley, School of Optometry","Berkeley","California","94720",{"type":53,"coordinates":69},[70,71],-122.27275,37.87159,{"lat":71,"lon":70},[74],{"name":75,"role":41,"phone":76,"phoneExt":26,"email":77},"Sarah Singh, OD PhD","510-664-5501","sarah_singh@berkeley.edu",{"facility":79,"status":80,"city":81,"state":66,"zip":82,"country":51,"cosmosGeoPoint":83,"geoPoint":87,"contacts":88},"Southern California College of Optometry at Marshall B. Ketchum University","RECRUITING","Fullerton","92831",{"type":53,"coordinates":84},[85,86],-117.92534,33.87029,{"lat":86,"lon":85},[89],{"name":90,"role":41,"phone":91,"phoneExt":26,"email":92},"Susan Parker","714-463-7580","research@ketchum.edu",{"facility":94,"status":47,"city":95,"state":66,"zip":96,"country":51,"cosmosGeoPoint":97,"geoPoint":101,"contacts":102},"Stanford University","Palo Alto","94303",{"type":53,"coordinates":98},[99,100],-122.14302,37.44188,{"lat":100,"lon":99},[103],{"name":104,"role":41,"phone":105,"phoneExt":26,"email":106},"Tawna Roberts, OD PhD","650-498-3154","tawnar@stanford.edu",{"facility":108,"status":80,"city":109,"state":110,"zip":111,"country":51,"cosmosGeoPoint":112,"geoPoint":116,"contacts":117},"Illinois College of Optometry","Chicago","Illinois","60616",{"type":53,"coordinates":113},[114,115],-87.65005,41.85003,{"lat":115,"lon":114},[118],{"name":119,"role":41,"phone":120,"phoneExt":26,"email":121},"Jessica Martinez","312-949-7340","Research@ico.edu",{"facility":123,"status":80,"city":124,"state":125,"zip":126,"country":51,"cosmosGeoPoint":127,"geoPoint":131,"contacts":132},"Indiana University","Bloomington","Indiana","47405",{"type":53,"coordinates":128},[129,130],-86.52639,39.16533,{"lat":130,"lon":129},[133],{"name":134,"role":41,"phone":135,"phoneExt":26,"email":136},"Amy Peterson, OD","812-856-0242","peteramy@iu.edu",{"facility":138,"status":80,"city":139,"state":140,"zip":141,"country":51,"cosmosGeoPoint":142,"geoPoint":146,"contacts":147},"New England College of Optometry","Boston","Massachusetts","02115",{"type":53,"coordinates":143},[144,145],-71.05977,42.35843,{"lat":145,"lon":144},[148],{"name":149,"role":41,"phone":150,"phoneExt":26,"email":151},"Tamara Khanjyan","617-587-5723","donutstudy@neco.edu",{"facility":153,"status":47,"city":154,"state":154,"zip":155,"country":51,"cosmosGeoPoint":156,"geoPoint":160,"contacts":161},"State University of New York College of Optometry","New York","10036",{"type":53,"coordinates":157},[158,159],-74.00597,40.71427,{"lat":159,"lon":158},[162],{"name":163,"role":41,"phone":164,"phoneExt":26,"email":165},"Xiaoying Zhu, OD PhD MD","212-938-5541","xzhu@sunyopt.edu",{"facility":167,"status":47,"city":168,"state":169,"zip":170,"country":51,"cosmosGeoPoint":171,"geoPoint":175,"contacts":176},"Case Western Reserve Department of Ophthalmology","Cleveland","Ohio","44106",{"type":53,"coordinates":172},[173,174],-81.69541,41.4995,{"lat":174,"lon":173},[177],{"name":178,"role":41,"phone":179,"phoneExt":26,"email":180},"Adam J Peiffer, OD","440-684-1743","adam.peiffer@uhhospitals.org",{"facility":37,"status":80,"city":182,"state":169,"zip":183,"country":51,"cosmosGeoPoint":184,"geoPoint":188,"contacts":189},"Columbus","43210",{"type":53,"coordinates":185},[186,187],-82.99879,39.96118,{"lat":187,"lon":186},[190],{"name":191,"role":41,"phone":192,"phoneExt":26,"email":193},"Heather Anderson, OD PhD","614-247-5825","anderson.3881@osu.edu",{"facility":195,"status":47,"city":196,"state":197,"zip":198,"country":51,"cosmosGeoPoint":199,"geoPoint":203,"contacts":204},"Pennsylvania College of Optometry at Drexel University","Elkins Park","Pennsylvania","19027",{"type":53,"coordinates":200},[201,202],-75.12684,40.07706,{"lat":202,"lon":201},[205],{"name":206,"role":41,"phone":26,"phoneExt":26,"email":207},"Erin Jenewein, OD, MS","ej468@drexel.edu",{"facility":209,"status":47,"city":210,"state":211,"zip":212,"country":51,"cosmosGeoPoint":213,"geoPoint":217,"contacts":218},"Southern College of Optometry","Memphis","Tennessee","38104",{"type":53,"coordinates":214},[215,216],-90.04898,35.14953,{"lat":216,"lon":215},[219],{"name":220,"role":41,"phone":221,"phoneExt":26,"email":222},"Marie Bodack, OD","901-722-3349","mbodack@sco.edu",{"facility":33,"status":47,"city":224,"state":225,"zip":226,"country":51,"cosmosGeoPoint":227,"geoPoint":231,"contacts":232},"Houston","Texas","77004",{"type":53,"coordinates":228},[229,230],-95.36327,29.76328,{"lat":230,"lon":229},[233],{"name":234,"role":41,"phone":235,"phoneExt":26,"email":236},"Eric Ritchey, OD PhD","713-743-1933","erritche@central.uh.edu",{"facility":238,"status":47,"city":239,"state":225,"zip":240,"country":51,"cosmosGeoPoint":241,"geoPoint":245,"contacts":246},"Rosenberg College of Optometry at the University of Incarnate Word","San Antonio","78229",{"type":53,"coordinates":242},[243,244],-98.49363,29.42412,{"lat":244,"lon":243},[247],{"name":248,"role":41,"phone":249,"phoneExt":26,"email":250},"Michelle Aaron, OD","210-283-6821","mtaaron@uiwtx.edu",{"type":252,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[254],{"name":255,"class":256},"National Eye Institute (NEI)","NIH","100636542",false,"NCT07567040","Delaying the Onset of Nearsightedness Until Treatment (DONUT) Clinical Trial","DONUT","Inclusion Criteria:\n\n* Refractive Error (cycloplegic autorefraction, spherical equivalent, at least one eye, inclusive) 6 years: -0.74 D to +0.75 D 7 and 8 years: -0.74 D to +0.50 D 9 and 10 years: -0.74 D to +0.25 D 11 years: -0.74 D to plano\n* Neither eye has -0.75 D or more myopia, spherical component\n* Anisometropia: Less than 1.50 D difference between OD and OS, cycloplegic autorefraction, spherical equivalent\n* Astigmatism: Less than 1.50 DC in both eyes by cycloplegic autorefraction\n* Successfully complete run-in period: take at least 90% of unit dose artificial tears for 2 to 4 weeks (# of unit-dose vials used divided by # nights since baseline visit must equal 0.90 or greater)\n\nExclusion Criteria:\n\n* If Visit 2 (randomization visit) is not completed within 4 weeks of the baseline, eligibility visit.\n* Presence of strabismus (intermittent or constant) based on unilateral cover test at distance and near\n* Known allergy to atropine\n* Systemic issues that may affect accommodation or convergence (e.g., multiple sclerosis, myasthenia gravis, Graves ophthalmopathy, diabetes mellitus, Parkinson's disease, Down syndrome, etc.)\n* Ocular disease (e.g., congenital glaucoma, retinal disease, nystagmus, amblyopia, etc.)\n* Ocular surgery (e.g., cataracts, strabismus)\n* Any previous myopia prevention\u002Fcontrol therapy (e.g., atropine, soft contact lenses, orthokeratology, myopia control spectacles, etc.) for more than one month\n* Pregnancy by self-report",true,"ALL","6 Years","11 Years",{"count":268,"type":269},664,"ESTIMATED","INTERVENTIONAL",[272],"PHASE3","The aims of this clinical trial will test whether or not the onset of nearsightedness is delayed in a group of children randomized to nightly drops in 0.05% atropine in both eyes, in comparison to children who receiving nightly placebo drops in both eyes. The primary outcome is the two-year cumulative incidence of nearsightedness. The second aim of this project will determine whether atropine is associated with slower eye growth in children receiving nightly drops of atropine versus placebo.",[275],"Myopia",[277],"prevention","2026-07-01",{"date":280,"type":281},"2026-07-02","ACTUAL",{"date":283,"type":281},"2026-05-27",{"date":285,"type":269},"2028-05-15",{"name":5,"class":6},14]