[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100379049":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":32,"centralContacts":37,"locations":47,"responsibleParty":97,"collaborators":100,"id":106,"slug":26,"hasResults":107,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":26,"eligibilityCriteria":111,"healthyVolunteers":107,"sex":112,"minAge":113,"maxAge":114,"enrollmentInfo":115,"targetDuration":26,"studyType":118,"phases":119,"briefSummary":121,"conditions":122,"keywords":124,"overallStatus":127,"whyStopped":26,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":137},{"fullName":5,"class":6},"Eye & ENT Hospital of Fudan University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"endonasal endoscopic surgery group","EXPERIMENTAL","143 participants in group 1 will undergo endoscopic surgery",[13],"Procedure: endonasal endoscopic surgery",{"label":15,"type":16,"description":17,"interventionNames":18},"radiation therapy group","ACTIVE_COMPARATOR","143 participants in group 2 will undergo radiation therapy(IMRT)",[19],"Radiation: radiation therapy(IMRT)",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","endonasal endoscopic surgery","143 patients will undergo endonasal endoscopic surgery",[9],null,{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":26},"RADIATION","radiation therapy(IMRT)","143 patients will undergo radiation therapy.",[15],[33],{"name":34,"affiliation":35,"role":36},"Hongmeng Yu, MD","Eye&ENT Hospital,Fudan University","PRINCIPAL_INVESTIGATOR",[38,43],{"name":39,"role":40,"phone":41,"phoneExt":26,"email":42},"Xiaole Song, MD","CONTACT","+86 15821388769","jxfxsxl@163.com",{"name":44,"role":40,"phone":45,"phoneExt":26,"email":46},"Zhihui Pang","+86 18818211894","pangzhihui1229@126.com",[48,66,80],{"facility":49,"status":26,"city":50,"state":51,"zip":26,"country":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Fujian Medical University Union Hospital","Fuzhou","Fujian","China",{"type":54,"coordinates":55},"Point",[56,57],119.30611,26.06139,{"lat":57,"lon":56},[60,62,64],{"name":61,"role":40,"phone":26,"phoneExt":26,"email":26},"Desheng Wang, MD",{"name":63,"role":40,"phone":26,"phoneExt":26,"email":26},"Haichun Lai, MD",{"name":65,"role":36,"phone":26,"phoneExt":26,"email":26},"Desheng Wang",{"facility":67,"status":26,"city":68,"state":69,"zip":26,"country":52,"cosmosGeoPoint":70,"geoPoint":74,"contacts":75},"The First Affiliated Hospital of Nanchang University","Nanchang","Jiangxi",{"type":54,"coordinates":71},[72,73],115.85306,28.68396,{"lat":73,"lon":72},[76,78],{"name":77,"role":40,"phone":26,"phoneExt":26,"email":26},"Jing Ye, MD",{"name":79,"role":36,"phone":26,"phoneExt":26,"email":26},"Jing Ye",{"facility":81,"status":26,"city":82,"state":83,"zip":84,"country":52,"cosmosGeoPoint":85,"geoPoint":89,"contacts":90},"Fudan University Shanghai cancer center","Shanghai","Shanghai Municipality","200000",{"type":54,"coordinates":86},[87,88],121.45806,31.22222,{"lat":88,"lon":87},[91,93,95],{"name":92,"role":40,"phone":26,"phoneExt":26,"email":26},"Lin Kong, MD",{"name":94,"role":40,"phone":26,"phoneExt":26,"email":26},"Jiyi Hu, MD",{"name":96,"role":36,"phone":26,"phoneExt":26,"email":26},"Lin Kong",{"type":36,"investigatorFullName":98,"investigatorTitle":99,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Hongmeng Yu","MD,PhD",[101,103],{"name":102,"class":6},"Chinese Academy of Medical Sciences",{"name":104,"class":105},"Shanghai Municipal Science and Technology Commission","OTHER_GOV","100379049",false,"NCT04215510","Early Recurrent Nasopharyngeal Cancer: the Effect of Surgery vs IMRT","A Multicenter Randomized Controlled Trial for Comparing Endonasal Surgery and Radiation Therapy (IMRT) for T1-T2 Recurrent Nasopharyngeal Carcinoma","Inclusion Criteria:\n\n1. Diagnosed of recurrent nasopharyngeal carcinoma by pathology or imaging study;\n2. Stage T1 or T2 according to AJCC 8th edition ;\n3. Aged 18 to 70 years;\n4. Without metastasis;\n5. previously received 1 course of radiotherapy;\n6. Without radiotherapy within 1 year, without local treatment for recurrent disease;\n7. Surgical resectable and IMRT suitable;\n8. If regional recurrence presented, regional lesion can be treated with local treatments.\n9. ECOG score 0 or 1;\n10. Sufficient organ function;\n11. Acceptable approach of contraception.\n\nExclusion Criteria:\n\n1. Refuse to sign inform consent;\n2. Radiation encephalopathy or leptomeningeal disease (LMD);\n3. History of radioactive particle planting;\n4. Have uncontrolled intercurrent illnesses which will interfere with the ability to undergo therapy;\n5. With prior malignancy (excluding adequately treated basal cell or squamous cell skin cancer, in-situ cervical cancer );\n6. Any contradiction to surgery;\n7. Have any co-existing condition that would preclude full compliance or safety with the study;\n8. Presence of a significant neurological or psychiatric disease, including dementia and seizures;\n9. Uncontrolled infectious diseases;\n10. Female patients who are at pregnancy or lactation.\n11. Without personal freedom or independent civil capacity.\n12. With serious autoimmune disease.\n13. Participants of other interventional clinical trial.","ALL","18 Years","70 Years",{"count":116,"type":117},286,"ESTIMATED","INTERVENTIONAL",[120],"PHASE3","This study is a multicenter RCT to compare 3-year overall survival(OS) rate, progression free survival(PFS),local progression free survival(LPFS),regional progression free survival(RPFS),distant metastasis free survival(DMFS), and toxicities of endonasal endoscopic surgery versus IMRT.",[123],"Recurrent Nasopharyngeal Carcinoma",[23,125,126],"radiation therapy","nasopharyngeal carcinoma","NOT_YET_RECRUITING","2021-02-20",{"date":130,"type":131},"2021-02-23","ACTUAL",{"date":133,"type":117},"2021-03-01",{"date":135,"type":117},"2027-03-01",{"name":5,"class":6},3]