[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100355761":3},{"organization":4,"armGroups":7,"interventions":29,"overallOfficials":35,"centralContacts":35,"locations":44,"responsibleParty":66,"collaborators":69,"id":73,"slug":35,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":35,"eligibilityCriteria":77,"healthyVolunteers":78,"sex":79,"minAge":80,"maxAge":35,"enrollmentInfo":81,"targetDuration":35,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":35,"overallStatus":47,"whyStopped":35,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"University of Alabama at Birmingham","OTHER",[8,15,21,25],{"label":9,"type":10,"description":11,"interventionNames":12},"Early Withdrawal Exposure plus NAW Regulation Training","EXPERIMENTAL","The development, application, modification, and repeated practice of individualized withdrawal regulation strategies (e.g., behavioral and cognitive strategies for allaying withdrawal symptoms) across the first 4 hours of abstinence over 4 separate sessions.",[13,14],"Behavioral: cognitive-behavioral withdrawal regulation strategies","Behavioral: early withdrawal exposure",{"label":16,"type":17,"description":18,"interventionNames":19},"Early Withdrawal Exposure plus Relaxation Control Training","ACTIVE_COMPARATOR","The development, application, modification, and repeated practice of relaxation strategies across the first 4 hours of abstinence over 4 separate sessions.",[20,14],"Behavioral: relaxation strategies",{"label":22,"type":17,"description":23,"interventionNames":24},"NAW Regulation Training Only","The development, application, modification, and repeated practice of individualized withdrawal regulation strategies (e.g., behavioral and cognitive strategies for allaying withdrawal symptoms) over 4 separate sessions involving smoking as usual.",[13],{"label":26,"type":17,"description":27,"interventionNames":28},"Relaxation Control Training Only","The development, application, modification, and repeated practice of relaxation strategies over 4 separate sessions involving smoking as usual.",[20],[30,36,40],{"type":31,"name":32,"description":33,"armGroupLabels":34,"otherNames":35},"BEHAVIORAL","cognitive-behavioral withdrawal regulation strategies","Participants will generate and refine individualized withdrawal regulation strategies with the aid of a therapist",[9,22],null,{"type":31,"name":37,"description":38,"armGroupLabels":39,"otherNames":35},"relaxation strategies","Participants will generate and refine relaxation techniques with the aid of a therapist",[16,26],{"type":31,"name":41,"description":42,"armGroupLabels":43,"otherNames":35},"early withdrawal exposure","Exposure to the first 4 hours of abstinence across 4 separate sessions",[9,16],[45],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Ryals Public Health Building","RECRUITING","Birmingham","Alabama","35294","United States",{"type":53,"coordinates":54},"Point",[55,56],-86.80249,33.52066,{"lat":56,"lon":55},[59,64],{"name":60,"role":61,"phone":62,"phoneExt":35,"email":63},"Peter S Hendricks, PhD","CONTACT","205.202.1387","phendricks@uab.edu",{"name":60,"role":65,"phone":35,"phoneExt":35,"email":35},"PRINCIPAL_INVESTIGATOR",{"type":65,"investigatorFullName":67,"investigatorTitle":68,"investigatorAffiliation":5,"oldNameTitle":35,"oldOrganization":35},"Peter Hendricks","University Professor",[70],{"name":71,"class":72},"National Institute on Drug Abuse (NIDA)","NIH","100355761",false,"NCT03912194","Early Withdrawal Exposure and Negative Affect Withdrawal (NAW) Regulation Training for Smoking Cessation","Inclusion Criteria:\n\n* at least 18 years of age\n* smoke at least 5 cigarettes per day\n* Expired breath carbon monoxide (CO) reading of at least five parts per million\n* report the intention to quit\n* reside in the Birmingham area with no plan to relocate outside of the area in the next 6 months\n* access to a telephone\n\nExclusion Criteria:\n\n* inability to speak English\n* presence of a condition that contraindicates use of the nicotine patch\n* presence of conditions that might interfere with compliance with the protocol or greatly complicate treatment\n* any acutely life-threatening disease\n* concurrent participation in a formal treatment program for smoking cessation\n* current use of any pharmacotherapy for smoking cessation",true,"ALL","18 Years",{"count":82,"type":83},400,"ESTIMATED","INTERVENTIONAL",[86],"PHASE3","Smoking remains the single most preventable cause of morbidity and mortality in the United States, accounting for approximately half a million deaths every year. The current study will investigate the efficacy and mechanisms of change of a novel smoking cessation intervention. The current study will thus provide essential information regarding a treatment that has the potential to enhance the efficacy of existing smoking cessation interventions, thereby having a beneficial impact on the public health of the United States.",[89],"Tobacco Dependence","2026-03-09",{"date":92,"type":93},"2026-03-11","ACTUAL",{"date":95,"type":93},"2019-08-01",{"date":97,"type":83},"2026-07-01",{"name":5,"class":6},1]