[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100460887":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":42,"centralContacts":35,"locations":47,"responsibleParty":590,"collaborators":592,"id":596,"slug":35,"hasResults":597,"nctId":598,"briefTitle":599,"officialTitle":600,"acronym":35,"eligibilityCriteria":601,"healthyVolunteers":597,"sex":602,"minAge":603,"maxAge":35,"enrollmentInfo":604,"targetDuration":35,"studyType":607,"phases":608,"briefSummary":610,"conditions":611,"keywords":619,"overallStatus":50,"whyStopped":35,"lastUpdateSubmitDate":641,"lastUpdatePostDateStruct":642,"startDateStruct":645,"completionDateStruct":647,"leadSponsor":649,"locationsCount":650},{"fullName":5,"class":6},"Genelux Corporation","INDUSTRY",[8,17],{"label":9,"type":10,"description":11,"interventionNames":12},"Olvi-Vec + Platinum-doublet & bevacizumab","EXPERIMENTAL","Olvi-Vec: A total of 2 consecutive days of intraperitoneal catheter infusions in Week 0\n\nPlatinum-doublet \\& bevacizumab (or biosimilar) administered beginning in Week 4 (preferred), but no later than Week 5",[13,14,15,16],"Biological: olvimulogene nanivacirepvec","Drug: Platinum chemotherapy: carboplatin (preferred) or cisplatin","Drug: Non-platinum chemotherapy: Physician's Choice of gemcitabine, taxane (paclitaxel, docetaxel or nab-paclitaxel) or pegylated liposomal doxorubicin","Drug: Bevacizumab (or biosimilar)",{"label":18,"type":19,"description":20,"interventionNames":21},"Physician's Choice of Chemotherapy & bevacizumab","ACTIVE_COMPARATOR","Physician's Choice of chemotherapy \\& bevacizumab (or biosimilar) administered beginning in Week 0. Physician's Choice of chemotherapy includes either a single agent non-platinum chemotherapy, or as platinum chemotherapy is allowed as an option, a platinum-doublet (i.e., platinum agent combined with a non-platinum agent).",[14,15,16],[23,30,36,39],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"BIOLOGICAL","olvimulogene nanivacirepvec","Olvi-Vec is an engineered oncolytic vaccinia virus",[9],[29],"GL-ONC1 and GLV-1h68",{"type":31,"name":32,"description":33,"armGroupLabels":34,"otherNames":35},"DRUG","Platinum chemotherapy: carboplatin (preferred) or cisplatin","Administered according to local practice",[9,18],null,{"type":31,"name":37,"description":33,"armGroupLabels":38,"otherNames":35},"Non-platinum chemotherapy: Physician's Choice of gemcitabine, taxane (paclitaxel, docetaxel or nab-paclitaxel) or pegylated liposomal doxorubicin",[9,18],{"type":31,"name":40,"description":33,"armGroupLabels":41,"otherNames":35},"Bevacizumab (or biosimilar)",[9,18],[43],{"name":44,"affiliation":45,"role":46},"Robert W. Holloway, MD","AdventHealth Cancer Institute","PRINCIPAL_INVESTIGATOR",[48,69,90,106,125,141,156,172,192,209,226,245,266,282,299,312,332,347,368,385,400,417,433,449,469,491,511,528,545,561,573],{"facility":49,"status":50,"city":51,"state":52,"zip":53,"country":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"The University of South Alabama, Mitchell Cancer Institute","RECRUITING","Mobile","Alabama","36604","United States",{"type":56,"coordinates":57},"Point",[58,59],-88.04305,30.69436,{"lat":59,"lon":58},[62,67],{"name":63,"role":64,"phone":65,"phoneExt":35,"email":66},"Stefanie White","CONTACT","251-445-9834","swhite@southalabama.edu",{"name":68,"role":46,"phone":35,"phoneExt":35,"email":35},"Jennifer Pierce, MD",{"facility":70,"status":50,"city":71,"state":72,"zip":73,"country":54,"cosmosGeoPoint":74,"geoPoint":78,"contacts":79},"University of Arizona Cancer Center","Tucson","Arizona","85719",{"type":56,"coordinates":75},[76,77],-110.92648,32.22174,{"lat":77,"lon":76},[80,84,88],{"name":81,"role":64,"phone":82,"phoneExt":35,"email":83},"Mitzi Miranda","520-626-0905","MMiranda@uacc.arizona.edu",{"name":85,"role":64,"phone":86,"phoneExt":35,"email":87},"Brianna Loughran","520-626-0939","bloughran@arizona.edu",{"name":89,"role":46,"phone":35,"phoneExt":35,"email":35},"Setsuko K. Chambers, MD",{"facility":91,"status":50,"city":92,"state":93,"zip":94,"country":54,"cosmosGeoPoint":95,"geoPoint":99,"contacts":100},"City of Hope","Duarte","California","91010",{"type":56,"coordinates":96},[97,98],-117.97729,34.13945,{"lat":98,"lon":97},[101,105],{"name":102,"role":64,"phone":103,"phoneExt":35,"email":104},"Edward Wang, MD, PhD","877-467-3411","edwang@coh.org",{"name":102,"role":46,"phone":35,"phoneExt":35,"email":35},{"facility":107,"status":50,"city":108,"state":93,"zip":109,"country":54,"cosmosGeoPoint":110,"geoPoint":114,"contacts":115},"UC San Diego Health - Moores Cancer Center","La Jolla","92093",{"type":56,"coordinates":111},[112,113],-117.2742,32.84727,{"lat":113,"lon":112},[116,120,122],{"name":117,"role":64,"phone":118,"phoneExt":35,"email":119},"Erika Peterson","858-822-5352","espeterson@health.ucsd.edu",{"name":121,"role":46,"phone":35,"phoneExt":35,"email":35},"Michael McHale, MD",{"name":123,"role":124,"phone":35,"phoneExt":35,"email":35},"Ramez Eskander, MD","SUB_INVESTIGATOR",{"facility":126,"status":50,"city":127,"state":93,"zip":128,"country":54,"cosmosGeoPoint":129,"geoPoint":133,"contacts":134},"Hoag Gynecologic Oncology","Newport Beach","92663",{"type":56,"coordinates":130},[131,132],-117.92895,33.61891,{"lat":132,"lon":131},[135,139],{"name":136,"role":64,"phone":137,"phoneExt":35,"email":138},"Esmeralda Martinez","949-764-5827","Esmeralda.Martinez@hoag.org",{"name":140,"role":46,"phone":35,"phoneExt":35,"email":35},"Alberto Mendivil, MD",{"facility":142,"status":50,"city":143,"state":93,"zip":144,"country":54,"cosmosGeoPoint":145,"geoPoint":149,"contacts":150},"UCI Health Chao Family Comprehensive Cancer Center","Orange","92868",{"type":56,"coordinates":146},[147,148],-117.85311,33.78779,{"lat":148,"lon":147},[151,155],{"name":152,"role":64,"phone":153,"phoneExt":35,"email":154},"Krishnansu S. Tewari, MD","714-456-7971","ktewari@hs.uci.edu",{"name":152,"role":46,"phone":35,"phoneExt":35,"email":35},{"facility":45,"status":50,"city":157,"state":158,"zip":159,"country":54,"cosmosGeoPoint":160,"geoPoint":164,"contacts":165},"Orlando","Florida","32804",{"type":56,"coordinates":161},[162,163],-81.37924,28.53834,{"lat":163,"lon":162},[166,170],{"name":167,"role":64,"phone":168,"phoneExt":35,"email":169},"Karla Hernandez-Cruz","407-609-4437","Karla.Hernandezcruz@AdventHealth.com",{"name":171,"role":46,"phone":35,"phoneExt":35,"email":35},"Robert W Holloway, MD",{"facility":173,"status":50,"city":174,"state":158,"zip":175,"country":54,"cosmosGeoPoint":176,"geoPoint":180,"contacts":181},"Sarasota Memorial Research Institute","Sarasota","34239",{"type":56,"coordinates":177},[178,179],-82.53065,27.33643,{"lat":179,"lon":178},[182,186,190],{"name":183,"role":64,"phone":184,"phoneExt":35,"email":185},"Kim Lacy","941-917-6519","kim-lacy@smh.com",{"name":187,"role":64,"phone":188,"phoneExt":35,"email":189},"Amanda Kinker","941-917-1211","amanda-kinker@smh.com",{"name":191,"role":46,"phone":35,"phoneExt":35,"email":35},"Beverly Long, MD",{"facility":193,"status":50,"city":194,"state":195,"zip":196,"country":54,"cosmosGeoPoint":197,"geoPoint":201,"contacts":202},"Emory University","Atlanta","Georgia","30322",{"type":56,"coordinates":198},[199,200],-84.38798,33.749,{"lat":200,"lon":199},[203,207],{"name":204,"role":64,"phone":205,"phoneExt":35,"email":206},"Winship Referrals","404-778-1900","winship.referrals@emoryhealthcare.org",{"name":208,"role":46,"phone":35,"phoneExt":35,"email":35},"Jennifer Scalici, MD",{"facility":210,"status":50,"city":211,"state":212,"zip":213,"country":54,"cosmosGeoPoint":214,"geoPoint":218,"contacts":219},"Indiana University Simon Comprehensive Cancer Center","Indianapolis","Indiana","46202",{"type":56,"coordinates":215},[216,217],-86.15804,39.76838,{"lat":217,"lon":216},[220,224],{"name":221,"role":64,"phone":222,"phoneExt":35,"email":223},"Cheri West, RN","317-278-3021","chawest@iu.edu",{"name":225,"role":46,"phone":35,"phoneExt":35,"email":35},"Jessica E. Parker, MD",{"facility":227,"status":50,"city":228,"state":229,"zip":230,"country":54,"cosmosGeoPoint":231,"geoPoint":235,"contacts":236},"Holy Cross Hospital","Silver Spring","Maryland","20910",{"type":56,"coordinates":232},[233,234],-77.02609,38.99067,{"lat":234,"lon":233},[237,241,243],{"name":238,"role":64,"phone":239,"phoneExt":35,"email":240},"Lyudmila Igorevna Kalnitskaya, MBA, MS","301-754-7552","kalnitsl@holycrosshealth.org",{"name":242,"role":46,"phone":35,"phoneExt":35,"email":35},"Frederick D Min, MD",{"name":244,"role":124,"phone":35,"phoneExt":35,"email":35},"Jasmine Ebott, MD",{"facility":246,"status":50,"city":247,"state":248,"zip":249,"country":54,"cosmosGeoPoint":250,"geoPoint":254,"contacts":255},"University of Michigan","Ann Arbor","Michigan","48109",{"type":56,"coordinates":251},[252,253],-83.74088,42.27756,{"lat":253,"lon":252},[256,260,264],{"name":257,"role":64,"phone":258,"phoneExt":35,"email":259},"Zhen Zhou","917-912-3028","zhenniz@med.umich.edu",{"name":261,"role":64,"phone":262,"phoneExt":35,"email":263},"Munira Hussain","734-936-8349","hussain@med.umich.edu",{"name":265,"role":46,"phone":35,"phoneExt":35,"email":35},"Jean Siedel, MD",{"facility":267,"status":50,"city":268,"state":248,"zip":269,"country":54,"cosmosGeoPoint":270,"geoPoint":274,"contacts":275},"Karmanos Cancer Institute","Detroit","48201",{"type":56,"coordinates":271},[272,273],-83.04575,42.33143,{"lat":273,"lon":272},[276,280],{"name":277,"role":64,"phone":278,"phoneExt":35,"email":279},"Elizabeth Linnik","313-576-9764","linnike@karmanos.org",{"name":281,"role":46,"phone":35,"phoneExt":35,"email":35},"Robert Morris, MD",{"facility":283,"status":50,"city":284,"state":285,"zip":286,"country":54,"cosmosGeoPoint":287,"geoPoint":291,"contacts":292},"Washington University School of Medicine","St Louis","Missouri","63110",{"type":56,"coordinates":288},[289,290],-90.19789,38.62727,{"lat":290,"lon":289},[293,297],{"name":294,"role":64,"phone":295,"phoneExt":35,"email":296},"Tiara Redrick","314-362-1705","tredrick@wustl.edu",{"name":298,"role":46,"phone":35,"phoneExt":35,"email":35},"Premal Thaker, MD",{"facility":300,"status":50,"city":284,"state":285,"zip":301,"country":54,"cosmosGeoPoint":302,"geoPoint":304,"contacts":305},"Mercy Hospital St. Louis","63141",{"type":56,"coordinates":303},[289,290],{"lat":290,"lon":289},[306,310],{"name":307,"role":64,"phone":308,"phoneExt":35,"email":309},"Enguday Teshome","314-251-0742","Enguday.teshome@mercy.net",{"name":311,"role":46,"phone":35,"phoneExt":35,"email":35},"Madhavi Manyam, MD",{"facility":313,"status":50,"city":314,"state":315,"zip":316,"country":54,"cosmosGeoPoint":317,"geoPoint":321,"contacts":322},"Women's Cancer Center of Nevada","Las Vegas","Nevada","89106",{"type":56,"coordinates":318},[319,320],-115.13722,36.17497,{"lat":320,"lon":319},[323,327,330],{"name":324,"role":64,"phone":325,"phoneExt":35,"email":326},"Thania Escamilla","702-851-4672","tescamilla@wccenter.com",{"name":328,"role":64,"phone":325,"phoneExt":35,"email":329},"Jacky Amador","Jamador@wccenter.com",{"name":331,"role":46,"phone":35,"phoneExt":35,"email":35},"Nicola M. Spirtos, MD",{"facility":333,"status":50,"city":334,"state":315,"zip":335,"country":54,"cosmosGeoPoint":336,"geoPoint":340,"contacts":341},"Center of Hope","Reno","89511",{"type":56,"coordinates":337},[338,339],-119.8138,39.52963,{"lat":339,"lon":338},[342,346],{"name":343,"role":64,"phone":344,"phoneExt":35,"email":345},"Peter Lim, MD","775-327-4611","Plim@cohreno.com",{"name":343,"role":46,"phone":35,"phoneExt":35,"email":35},{"facility":348,"status":50,"city":349,"state":350,"zip":351,"country":54,"cosmosGeoPoint":352,"geoPoint":356,"contacts":357},"Stony Brook Cancer Center","Stony Brook","New York","11794",{"type":56,"coordinates":353},[354,355],-73.14094,40.92565,{"lat":355,"lon":354},[358,362,366],{"name":359,"role":64,"phone":360,"phoneExt":35,"email":361},"Latrice Tribble-Jones","631-216-2988","latrice.tribble@stonybrookmedicine.edu",{"name":363,"role":64,"phone":364,"phoneExt":35,"email":365},"Anu John, MSN, RN","631-972-0147","Anu.John@stonybrookmedicine.edu",{"name":367,"role":46,"phone":35,"phoneExt":35,"email":35},"Gabrielle Gossner, MD",{"facility":369,"status":50,"city":370,"state":371,"zip":372,"country":54,"cosmosGeoPoint":373,"geoPoint":377,"contacts":378},"Levine Cancer Institute","Charlotte","North Carolina","28204",{"type":56,"coordinates":374},[375,376],-80.84313,35.22709,{"lat":376,"lon":375},[379,383],{"name":380,"role":64,"phone":381,"phoneExt":35,"email":382},"Leah Wilson","980-442-2333","Leah.J.Wilson@atriumhealth.org",{"name":384,"role":46,"phone":35,"phoneExt":35,"email":35},"Erin K Crane, MD",{"facility":386,"status":50,"city":387,"state":371,"zip":388,"country":54,"cosmosGeoPoint":389,"geoPoint":393,"contacts":394},"East Carolina University","Greenville","27834",{"type":56,"coordinates":390},[391,392],-77.36635,35.61266,{"lat":392,"lon":391},[395,399],{"name":396,"role":64,"phone":397,"phoneExt":35,"email":398},"Grainger Lanneau, MD","252-816-2743","Grainger.Lanneau@ecuhealth.org",{"name":396,"role":46,"phone":35,"phoneExt":35,"email":35},{"facility":401,"status":50,"city":402,"state":403,"zip":404,"country":54,"cosmosGeoPoint":405,"geoPoint":409,"contacts":410},"Cleveland Clinic","Cleveland","Ohio","44195",{"type":56,"coordinates":406},[407,408],-81.69541,41.4995,{"lat":408,"lon":407},[411,415],{"name":412,"role":64,"phone":413,"phoneExt":35,"email":414},"Barbara Bittel","216-390-2456","Bittelb@ccf.org",{"name":416,"role":46,"phone":35,"phoneExt":35,"email":35},"Peter Rose, MD",{"facility":418,"status":50,"city":419,"state":403,"zip":420,"country":54,"cosmosGeoPoint":421,"geoPoint":425,"contacts":426},"OhioHealth Research Institute","Columbus","43214",{"type":56,"coordinates":422},[423,424],-82.99879,39.96118,{"lat":424,"lon":423},[427,431],{"name":428,"role":64,"phone":429,"phoneExt":35,"email":430},"Jennifer Sexton","614-788-3860","Jennifer.Sexton@ohiohealth.com",{"name":432,"role":46,"phone":35,"phoneExt":35,"email":35},"Aine Clements, MD",{"facility":434,"status":50,"city":435,"state":403,"zip":436,"country":54,"cosmosGeoPoint":437,"geoPoint":441,"contacts":442},"Kettering Health","Kettering","45429",{"type":56,"coordinates":438},[439,440],-84.16883,39.6895,{"lat":440,"lon":439},[443,447],{"name":444,"role":64,"phone":445,"phoneExt":35,"email":446},"Daniel Geyer","937-395-6017","daniel.geyer@ketteringhealth.org",{"name":448,"role":46,"phone":35,"phoneExt":35,"email":35},"Thomas J. Reid, MD",{"facility":450,"status":50,"city":451,"state":403,"zip":452,"country":54,"cosmosGeoPoint":453,"geoPoint":457,"contacts":458},"ProMedica Flower Hospital","Sylvania","43560",{"type":56,"coordinates":454},[455,456],-83.71299,41.71894,{"lat":456,"lon":455},[459,463,467],{"name":460,"role":64,"phone":461,"phoneExt":35,"email":462},"Carissa Jock","419-824-1011","Carissa.jock@promedica.org",{"name":464,"role":64,"phone":465,"phoneExt":35,"email":466},"Julie Moon","419-824-8812","Julie.moon@promedica.org",{"name":468,"role":46,"phone":35,"phoneExt":35,"email":35},"Adam Walter, MD",{"facility":470,"status":50,"city":471,"state":472,"zip":473,"country":54,"cosmosGeoPoint":474,"geoPoint":478,"contacts":479},"Oklahoma University Health Stephenson Cancer Center","Oklahoma City","Oklahoma","73104",{"type":56,"coordinates":475},[476,477],-97.51643,35.46756,{"lat":477,"lon":476},[480,485,490],{"name":481,"role":64,"phone":482,"phoneExt":483,"email":484},"Nikolas Williams","405-271-8001","18001","nikolas-williams@ou.edu",{"name":486,"role":64,"phone":487,"phoneExt":488,"email":489},"Debra Richardson, MD","405-271-1112","31839","debra-richardson@ou.edu",{"name":486,"role":46,"phone":35,"phoneExt":35,"email":35},{"facility":492,"status":50,"city":493,"state":494,"zip":495,"country":54,"cosmosGeoPoint":496,"geoPoint":500,"contacts":501},"AHN West Penn Hospital","Pittsburgh","Pennsylvania","15224",{"type":56,"coordinates":497},[498,499],-79.99589,40.44062,{"lat":499,"lon":498},[502,506,510],{"name":503,"role":64,"phone":504,"phoneExt":35,"email":505},"Sarah Crafton, MD","412-578-1116","Sarah.Crafton@ahn.org",{"name":507,"role":64,"phone":508,"phoneExt":35,"email":509},"AHN Clinical Trial","412-359-3731","clinicaltrials@ahn.org",{"name":503,"role":46,"phone":35,"phoneExt":35,"email":35},{"facility":512,"status":50,"city":513,"state":514,"zip":515,"country":54,"cosmosGeoPoint":516,"geoPoint":520,"contacts":521},"Hollings Cancer Center","Charleston","South Carolina","29425",{"type":56,"coordinates":517},[518,519],-79.93275,32.77632,{"lat":519,"lon":518},[522,526],{"name":523,"role":64,"phone":524,"phoneExt":35,"email":525},"Crystal Knox","843-792-2803","knoxc@musc.edu",{"name":527,"role":46,"phone":35,"phoneExt":35,"email":35},"Brian Orr, MD",{"facility":529,"status":50,"city":530,"state":531,"zip":532,"country":54,"cosmosGeoPoint":533,"geoPoint":537,"contacts":538},"Erlanger Health, Inc.","Chattanooga","Tennessee","37403",{"type":56,"coordinates":534},[535,536],-85.30968,35.04563,{"lat":536,"lon":535},[539,543],{"name":540,"role":64,"phone":541,"phoneExt":35,"email":542},"Lorraine Christensen","423-778-3902","Lorraine.Christensen@erlanger.org",{"name":544,"role":46,"phone":35,"phoneExt":35,"email":35},"Stephen DePasquale, MD",{"facility":546,"status":50,"city":547,"state":548,"zip":549,"country":54,"cosmosGeoPoint":550,"geoPoint":554,"contacts":555},"Baylor College of Medicine","Houston","Texas","77030",{"type":56,"coordinates":551},[552,553],-95.36327,29.76328,{"lat":553,"lon":552},[556,560],{"name":557,"role":64,"phone":558,"phoneExt":35,"email":559},"Jan Sunde, MD","832-957-6500","jan.sunde@bcm.edu",{"name":557,"role":46,"phone":35,"phoneExt":35,"email":35},{"facility":562,"status":50,"city":547,"state":548,"zip":549,"country":54,"cosmosGeoPoint":563,"geoPoint":565,"contacts":566},"University of Texas Science Center at Houston, McGovern Medical School",{"type":56,"coordinates":564},[552,553],{"lat":553,"lon":552},[567,571],{"name":568,"role":64,"phone":569,"phoneExt":35,"email":570},"Gabrielle Hayes","713-704-4137","gabrielle.a.hayes@uth.tmc.edu",{"name":572,"role":46,"phone":35,"phoneExt":35,"email":35},"Joseph Lucci, III, MD",{"facility":574,"status":50,"city":575,"state":576,"zip":577,"country":54,"cosmosGeoPoint":578,"geoPoint":582,"contacts":583},"Providence Sacred Heart Medical Center & Children's Hospital","Spokane","Washington","99204",{"type":56,"coordinates":579},[580,581],-117.42908,47.65966,{"lat":581,"lon":580},[584,588],{"name":585,"role":64,"phone":586,"phoneExt":35,"email":587},"Jodie Mactagone, CRC","509-474-3821","Jodie.mactagone@providence.org",{"name":589,"role":46,"phone":35,"phoneExt":35,"email":35},"Melanie Bergman, MD",{"type":591,"investigatorFullName":35,"investigatorTitle":35,"investigatorAffiliation":35,"oldNameTitle":35,"oldOrganization":35},"SPONSOR",[593],{"name":594,"class":595},"GOG Foundation","NETWORK","100460887",false,"NCT05281471","Efficacy & Safety of Olvi-Vec and Platinum-doublet + Bevacizumab Compared to Physician's Choice of Chemotherapy and Bevacizumab in Platinum-Resistant\u002FRefractory Ovarian Cancer (PRROC) (OnPrime, GOG-3076)","A Randomized Phase 3 Study Assessing the Efficacy and Safety of Olvi-Vec Followed by Platinum-doublet Chemotherapy and Bevacizumab Compared With Physician's Choice of Chemotherapy and Bevacizumab in Women With Platinum-Resistant\u002FRefractory Ovarian Cancer (PRROC) (OnPrime, GOG-3076)","Inclusion Criteria:\n\n* Histologically confirmed (from prior treatment) non-resectable ovarian, fallopian tube or primary peritoneal cancer.\n* High-grade serous \\[including malignant mixed Mullerian tumor (MMMT) with metastasis that contains high-grade epithelial carcinoma, FIGO grades 2 \\& 3 allowed\\], endometrioid, or clear-cell ovarian cancer.\n* Performance status ECOG of 0 or 1.\n* Life expectancy of at least 6 months.\n* Received a minimum of 3 prior lines (including the 1st line) of systemic therapy with no maximal limit.\n* Platinum-resistant or -refractory disease based on platinum-free interval (PFI) from the last dose of the most recent. platinum-based line of therapy (must have received a minimum of 2 doses of platinum in that line) to subsequent disease progression based on radiological assessment. Platinum-refractory: PFI of \\\u003C 1 month (including disease progression while on platinum-based therapy). Platinum-resistant: PFI of 1-6 months.\n* Received prior bevacizumab (or biosimilar) treatment.\n* No contraindication to receive carboplatin, cisplatin or bevacizumab (or biosimilar).\n* Have disease progression after last prior line of therapy based on radiological assessment prior to randomization.\n* At least 1 measurable target lesion per RECIST 1.1 based on abdominal\u002Fpelvis imaging scan at screening.\n* Evidence by CT and\u002For PET scans or physical exam of abdominal\u002Fpelvis region likely having disease in the peritoneal cavity (i.e., peritoneal carcinomatosis).\n* Adequate renal, hepatic, bone marrow function, adequate coagulation tests, adequate immune function by lymphocyte count.\n\nExclusion Criteria:\n\n* Tumors of mucinous, low-grade serous, squamous cell, small cell neuroendocrine subtypes, MMMT tumors absent an epithelial component on recent biopsy, or non-epithelial ovarian cancers (e.g., germ cell tumors, Sex-cord tumors).\n* Bowel obstruction within last 3 months prior to screening.\n* Active urinary tract infection, pneumonia, other systemic infections.\n* Active gastrointestinal bleeding.\n* Known current central nervous system (CNS) metastasis.\n* Inflammatory diseases of the bowel.\n* History of HIV infection.\n* Active hepatitis B virus or hepatitis C virus within 4 weeks prior to study.\n* History of thromboembolic event within the prior 3 months.\n* Contraindications for intraperitoneal (IP) catheter placement: Bowel obstruction with distended abdomen, rigid abdomen with bulky anterior wall carcinomatosis, abdominal wall hernia mesh that precludes laparoscopic entry to abdomen.\n* Clinically significant cardiac disease at screening (New York Heart Association Class III\u002FIV).\n* Acute cerebrovascular event(s) such as cerebrovascular accident (CVA) or transient ischemic attack (TIA) in previous 6 months.\n* Oxygen saturation \\\u003C90%.\n* Received prior virus-based gene therapy or therapy with cytolytic virus of any type.\n* Receiving concurrent antiviral agent.\n* Prior malignancy of other histology active within previous 3 years except for locally curable cancers apparently cured such as basal\u002Fsquamous cell skin cancer, superficial bladder cancer, carcinoma in situ of cervix or breast, any other stage I\u002FII local malignancies.\n* Received chemotherapy, radiotherapy, other anti-cancer biologic therapies within 4 weeks prior to planned treatment.\n* Underwent surgery within 4 weeks, or have insufficient recovery from surgical-related trauma or wound healing, prior to first study treatment in either Arm.\n* Receiving immunosuppressive therapy or steroids (except acute concurrent corticosteroid of no more than 20 mg per day for medical management with prednisolone equivalent.\n* Symptomatic malignant ascites or pleural effusions defined as rapidly progressive ascites with abdominal distension and gastrointestinal dysfunction, pleural effusions with respiratory difficulties requiring frequent paracentesis \\> once every 14 days.\n* Known hypersensitivity to gentamicin.","FEMALE","18 Years",{"count":605,"type":606},186,"ESTIMATED","INTERVENTIONAL",[609],"PHASE3","The OnPrime study is a multi-center, randomized open-label phase 3 study evaluating the safety and efficacy of Olvi-Vec followed by platinum-doublet chemotherapy and bevacizumab compared to the Active Comparator Arm with Physician's Choice of chemotherapy and bevacizumab in women diagnosed with platinum-resistant\u002Frefractory ovarian cancer (includes fallopian tube cancer and primary peritoneal cancer). This Phase III trial builds on the efficacy and safety data reported in the previous Phase II VIRO-15 trial with promising objective response rate and progression-free survival observed in heavily pre-treated patients with platinum-resistant\u002Frefractory ovarian cancer. The phase II results also showed that the intra-peritoneal route of delivery was efficient in generating tumor cell killing and immune activation, and led to clinical reversal of platinum-resistance or refractoriness in this difficult-to-treat patient population.",[612,613,614,615,616,617,618],"Platinum-resistant Ovarian Cancer","Platinum-refractory Ovarian Cancer","Fallopian Tube Cancer","Primary Peritoneal Cancer","High-grade Serous Ovarian Cancer","Endometrioid Ovarian Cancer","Ovarian Clear Cell Carcinoma",[25,620,621,622,623,624,625,626,627,628,629,630,631,632,633,634,635,636,637,638,639,640],"GL-ONC1","GLV-1h68","oncolytic virus","virotherapy","viral therapy","immunotherapy","immunochemotherapy","combination therapy","vaccinia virus","ovarian cancer","fallopian tube cancer","primary peritoneal cancer","platinum resistant","platinum refractory","recurrent ovarian cancer","platinum resensitization","chemoresistance","heavily pre-treated","immune activation","reversal of platinum resistance or refractoriness","resensitize","2026-03-16",{"date":643,"type":644},"2026-03-18","ACTUAL",{"date":646,"type":644},"2022-08-31",{"date":648,"type":606},"2026-10",{"name":5,"class":6},31]