The prevalence of post-surgical lumbar neuropathic radiculopathy is approximately 30%. Poor response to the treatments recommended for neuropathic pain, namely antidepressants and/or gabapentinoids, requires the development of new techniques to prevent this chronic pain. Certain well-tolerated techniques, such as the administration of plasma enriched with platelets and fibrin (PRF), are increasingly used in regenerative medicine for their anti-inflammatory and analgesic properties. Thus, a periradicular intraoperative application of PRF may have an analgesic effect on the intensity of residual postsurgical neuropathic pain after disc herniation surgery.
Patient, male or female, >18 years old at the time of signing informed consent;
Patient for whom a diagnosis of radiculopathy on lumbar disc herniation has been made, and for whom surgery has been scheduled in the Neurosurgery department;
Patient affiliated to a social security health insurance scheme;
Patient able to understand the objectives and risks of research and to give informed, dated and signed consent;
Patient with a history of lumbar spinal surgery (multiple herniated discs, herniated disc other than lumbar);
Patient with HIV, active cancer, HBV, HCV (verified by interview);
Patient on long-term systemic corticosteroid therapy;
Patient with an ASA score > 3 during the consultation with the anesthesiologist;
University Hospital, Strasbourg, France
Lead sponsor