[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100454358":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":25,"locations":31,"responsibleParty":61,"collaborators":24,"id":63,"slug":24,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":64,"sex":70,"minAge":71,"maxAge":24,"enrollmentInfo":72,"targetDuration":24,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":82,"overallStatus":34,"whyStopped":24,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"University Hospital, Strasbourg, France","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental group","ACTIVE_COMPARATOR","Surgery for disc herniation and intraoperative periradicular administration of PRF",[13],"Biological: Treatment",{"label":15,"type":10,"description":16,"interventionNames":17},"Control group","Surgery for disc herniation alone (i.e. reference treatment).",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"BIOLOGICAL","Treatment","Experimental product: product derived from autologous blood, obtained after centrifugation.\n\nTreatment modalities: intraoperative periradicular administration of autologous PRF.",[15,9],null,[26],{"name":27,"role":28,"phone":29,"phoneExt":24,"email":30},"Erci SALVAT","CONTACT","+33 3 88 12 85 02","eric.salvat@chru-strasbourg.fr",[32],{"facility":33,"status":34,"city":35,"state":36,"zip":37,"country":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Les Hôpitaux Universitaires","RECRUITING","Strasbourg","Bas-Rhin","67091","France",{"type":40,"coordinates":41},"Point",[42,43],7.74553,48.58392,{"lat":43,"lon":42},[46,48,51,53,55,57,59],{"name":47,"role":28,"phone":29,"phoneExt":24,"email":30},"Eric SALVAT",{"name":49,"role":50,"phone":24,"phoneExt":24,"email":24},"Daniel TIMBOLSCHI IONUT","SUB_INVESTIGATOR",{"name":52,"role":50,"phone":24,"phoneExt":24,"email":24},"Lauriane JOGANAH",{"name":54,"role":50,"phone":24,"phoneExt":24,"email":24},"André MULLER",{"name":56,"role":50,"phone":24,"phoneExt":24,"email":24},"Yohann BOHREN",{"name":58,"role":50,"phone":24,"phoneExt":24,"email":24},"François PROUST",{"name":60,"role":50,"phone":24,"phoneExt":24,"email":24},"Hugo Andres COCA",{"type":62,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR","100454358",false,"NCT05196503","Efficacy of an Intraoperative Periradicular Application of Platelet Rich Fibrin (PRF) on the Intensity of Residual Post-surgical Neuropathic Pain After a Surgery for Disc Herniation","Efficacy of Platelet Rich Fibrin in the Prevention of Residual Neuropathic Pain Following Disc Herniation Surgery","NeuroPRF","Inclusion criteria:\n\n* Patient, male or female, \\>18 years old at the time of signing informed consent;\n* Patient for whom a diagnosis of radiculopathy on lumbar disc herniation has been made, and for whom surgery has been scheduled in the Neurosurgery department;\n* Patient affiliated to a social security health insurance scheme;\n* Patient able to understand the objectives and risks of research and to give informed, dated and signed consent;\n* Patient having been informed of the results of the prior medical examination;\n* Women of childbearing age provided that a negative blood pregnancy test is recorded at the inclusion visit and effective contraception used throughout the study.\n\nExclusion criteria:\n\n* Patient with a history of lumbar spinal surgery (multiple herniated discs, herniated disc other than lumbar);\n* Patient with HIV, active cancer, HBV, HCV (verified by interview);\n* Patient on long-term systemic corticosteroid therapy;\n* Patient with an ASA score \\> 3 during the consultation with the anesthesiologist;\n* Inability to give the patient informed information (patient in an emergency or life-threatening situation, difficulties in understanding);\n* Patient in exclusion period (determined by a previous or ongoing study);\n* Subject under safeguard of justice;\n* Subject under curatorship;\n* Pregnancy;\n* Breastfeeding.","ALL","18 Years",{"count":73,"type":74},60,"ESTIMATED","INTERVENTIONAL",[77],"PHASE3","The prevalence of post-surgical lumbar neuropathic radiculopathy is approximately 30%. Poor response to the treatments recommended for neuropathic pain, namely antidepressants and\u002For gabapentinoids, requires the development of new techniques to prevent this chronic pain. Certain well-tolerated techniques, such as the administration of plasma enriched with platelets and fibrin (PRF), are increasingly used in regenerative medicine for their anti-inflammatory and analgesic properties. Thus, a periradicular intraoperative application of PRF may have an analgesic effect on the intensity of residual postsurgical neuropathic pain after disc herniation surgery.",[80,81],"Neuropathic Pain","Chronic Postsurgical Pain",[83,84,85,86],"Neuropathic pain","Chronic postsurgical pain prevention","Intraoperative platelet rich fibrin","Disc herniation surgery","2026-06-05",{"date":89,"type":90},"2026-06-08","ACTUAL",{"date":92,"type":90},"2022-02-23",{"date":94,"type":74},"2028-01",{"name":5,"class":6},1]