[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636191":3},{"organization":4,"outcomesModule":7,"designInfo":13,"detailedDescription":11,"studyPopulation":11,"armGroups":19,"interventions":28,"overallOfficials":11,"centralContacts":11,"locations":11,"responsibleParty":34,"collaborators":11,"id":38,"slug":11,"hasResults":39,"nctId":40,"briefTitle":41,"officialTitle":41,"acronym":11,"eligibilityCriteria":42,"healthyVolunteers":39,"sex":43,"minAge":44,"maxAge":45,"enrollmentInfo":46,"targetDuration":11,"studyType":49,"phases":50,"briefSummary":52,"conditions":53,"keywords":11,"overallStatus":55,"whyStopped":11,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":11},{"fullName":5,"class":6},"Capital Medical University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":11,"otherOutcomes":11},[9],{"measure":10,"description":11,"timeFrame":12},"Percentage change in 24-hour mean systolic blood pressure from baseline.",null,"30 days",{"allocation":14,"interventionModel":15,"interventionModelDescription":11,"primaryPurpose":16,"observationalModel":11,"timePerspective":11,"maskingInfo":17},"NON_RANDOMIZED","PARALLEL","TREATMENT",{"masking":18,"maskingDescription":11,"whoMasked":11},"NONE",[20,25],{"label":21,"type":22,"description":11,"interventionNames":23},"RIC group","EXPERIMENTAL",[24],"Device: RIC",{"label":26,"type":27,"description":11,"interventionNames":11},"Control group","NO_INTERVENTION",[29],{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":11},"DEVICE","RIC","Participants will undergo a 7-day remote ischemic conditioning (RIC) intervention prior to ascending to high altitude. On the day following the completion of the RIC intervention, they will ascend to a high-altitude region (\\>2500 m). Standardized RIC treatment will be administered using a dedicated RIC device. Each intervention session consists of 5 cycles. Every cycle includes 5 minutes of bilateral upper limb ischemia followed by 5 minutes of reperfusion. The cuff pressure for inducing ischemia is set at 200 mmHg. The intervention is administered twice daily for 30 consecutive days.",[21],{"type":35,"investigatorFullName":36,"investigatorTitle":37,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Ji Xunming,MD,PhD","PhD","100636191",false,"NCT07562477","Efficacy of Remote Ischemic Conditioning for Hypertension in High-Altitude Immigrant Populations","Inclusion Criteria:\n\nAge 18-60 years, of either sex; Continuous residence in a high-altitude region (\\>2500 m) for more than 6 months, with no plan for long-term departure from the plateau during the study period; Meeting the diagnostic criteria for essential hypertension; Willing to provide written informed consent.\n\nExclusion Criteria:\n\nEvidence of secondary hypertension; Severe dysfunction of vital organs (e.g., heart, liver, kidney, lungs); Active malignancy, uncontrolled hyperthyroidism, active autoimmune disease, or poorly controlled diabetes mellitus; Office blood pressure ≥180\u002F110 mmHg, or 24-hour average blood pressure ≥170\u002F100 mmHg; Hospitalization for hypertensive crisis or emergency at least once within the past 3 months; History of cardiovascular or cerebrovascular event within the past 3 months; Pregnancy, planned pregnancy, or lactation for female participants; Contraindications to RIC (e.g., severe peripheral arterial disease, venous thrombosis, or soft tissue injury in the upper limbs); Any other condition deemed by the investigator to be unsuitable for participation in the study.","ALL","18 Years","60 Years",{"count":47,"type":48},184,"ESTIMATED","INTERVENTIONAL",[51],"PHASE3","This study is a multicenter, prospective, randomized, open-label, parallel-controlled clinical trial. The study participants are adult patients with hypertension who have been long-term residents (for \\>6 months) in high-altitude regions (≥2500 m). They are randomly assigned to one of two groups: a conventional medication group and a remote ischemic conditioning (RIC) intervention group. The study aims to evaluate the effectiveness of a standardized 30-day RIC intervention, as an add-on to conventional antihypertensive medication, for reducing blood pressure in hypertensive immigrants living at high altitude.",[54],"Hypertension","NOT_YET_RECRUITING","2026-04-25",{"date":58,"type":59},"2026-05-01","ACTUAL",{"date":61,"type":48},"2026-05-10",{"date":63,"type":48},"2028-06-30",{"name":5,"class":6}]