[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100467937":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":34,"locations":43,"responsibleParty":182,"collaborators":26,"id":185,"slug":26,"hasResults":186,"nctId":187,"briefTitle":188,"officialTitle":188,"acronym":189,"eligibilityCriteria":190,"healthyVolunteers":186,"sex":191,"minAge":192,"maxAge":193,"enrollmentInfo":194,"targetDuration":26,"studyType":197,"phases":198,"briefSummary":200,"conditions":201,"keywords":203,"overallStatus":46,"whyStopped":26,"lastUpdateSubmitDate":208,"lastUpdatePostDateStruct":209,"startDateStruct":212,"completionDateStruct":214,"leadSponsor":216,"locationsCount":217},{"fullName":5,"class":6},"University Medical Center Groningen","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Hydrochlorothiazide","ACTIVE_COMPARATOR","Oral hydrochlorothiazide 25mg, once daily, for a total of 156 weeks",[13],"Drug: Hydrochlorothiazide 25 mg",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo","PLACEBO_COMPARATOR","Matching oral placebo, once daily, for a total of 156 weeks. The placebo is inert.",[19],"Drug: Placebo",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Hydrochlorothiazide 25 mg","An oral capsule containing 25mg of hydrochlorothiazide",[9],null,{"type":22,"name":15,"description":28,"armGroupLabels":29,"otherNames":26},"A matching oral capsule containing placebo",[15],[31],{"name":32,"affiliation":5,"role":33},"Prof. dr. R.T. Gansevoort","PRINCIPAL_INVESTIGATOR",[35,40],{"name":36,"role":37,"phone":38,"phoneExt":26,"email":39},"Dr. E Meijer","CONTACT","+31 50 3616161","esther.meijer@umcg.nl",{"name":41,"role":37,"phone":26,"phoneExt":26,"email":42},"T. Bais, MD","t.bais@umcg.nl",[44,58,69,81,92,104,115,126,138,148,159,171],{"facility":45,"status":46,"city":47,"state":26,"zip":26,"country":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Cliniques Universitaires Saint-Luc","RECRUITING","Brussels","Belgium",{"type":50,"coordinates":51},"Point",[52,53],4.34878,50.85045,{"lat":53,"lon":52},[56],{"name":57,"role":37,"phone":26,"phoneExt":26,"email":26},"Prof. Nathalie Demoulin",{"facility":59,"status":46,"city":60,"state":26,"zip":26,"country":48,"cosmosGeoPoint":61,"geoPoint":65,"contacts":66},"University Hospital Leuven","Leuven",{"type":50,"coordinates":62},[63,64],4.70093,50.87959,{"lat":64,"lon":63},[67],{"name":68,"role":37,"phone":26,"phoneExt":26,"email":26},"Prof dr. B. 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Klinik und Poliklinik III, Universitätsklinikum Dresden.","Dresden",{"type":50,"coordinates":119},[120,121],13.73832,51.05089,{"lat":121,"lon":120},[124],{"name":125,"role":37,"phone":26,"phoneExt":26,"email":26},"Alexander Paliege",{"facility":127,"status":46,"city":128,"state":26,"zip":26,"country":129,"cosmosGeoPoint":130,"geoPoint":134,"contacts":135},"Amsterdam University Medical Center","Amsterdam","Netherlands",{"type":50,"coordinates":131},[132,133],4.88969,52.37403,{"lat":133,"lon":132},[136],{"name":137,"role":37,"phone":26,"phoneExt":26,"email":26},"Prof dr. M. van Ittersum",{"facility":5,"status":46,"city":139,"state":26,"zip":26,"country":129,"cosmosGeoPoint":140,"geoPoint":144,"contacts":145},"Groningen",{"type":50,"coordinates":141},[142,143],6.56667,53.21917,{"lat":143,"lon":142},[146],{"name":147,"role":37,"phone":38,"phoneExt":26,"email":39},"dr. E. Meijer",{"facility":149,"status":46,"city":150,"state":26,"zip":26,"country":129,"cosmosGeoPoint":151,"geoPoint":155,"contacts":156},"Erasmus University Medical Center","Rotterdam",{"type":50,"coordinates":152},[153,154],4.47917,51.9225,{"lat":154,"lon":153},[157],{"name":158,"role":37,"phone":26,"phoneExt":26,"email":26},"dr. M. Salih",{"facility":160,"status":46,"city":161,"state":26,"zip":26,"country":162,"cosmosGeoPoint":163,"geoPoint":167,"contacts":168},"Fundación Puigvert","Barcelona","Spain",{"type":50,"coordinates":164},[165,166],2.15899,41.38879,{"lat":166,"lon":165},[169],{"name":170,"role":37,"phone":26,"phoneExt":26,"email":26},"Prof. dr. R. Torra",{"facility":172,"status":46,"city":173,"state":26,"zip":26,"country":162,"cosmosGeoPoint":174,"geoPoint":178,"contacts":179},"La Fundación Jiménez Díaz","Madrid",{"type":50,"coordinates":175},[176,177],-3.70256,40.4165,{"lat":177,"lon":176},[180],{"name":181,"role":37,"phone":26,"phoneExt":26,"email":26},"María Vanessa Pérez Gómez",{"type":33,"investigatorFullName":183,"investigatorTitle":184,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Ron Gansevoort","Prof. dr.","100467937",false,"NCT05373264","HYDROchlorothiazide to PROTECT Polycystic Kidney Disease Patients and Improve Their Quality of Life","HYDRO-PROTECT","Inclusion Criteria:\n\n* ADPKD diagnosis (modified Ravine criteria)\n* ≥18 years old\n* eGFR \\> 25 mL\u002Fmin\u002F1.73m2\n* On stable treatment with the highest tolerated dose of V2RA for a minimum of 3 months\n\nExclusion Criteria:\n\n* Known intolerance to hydrochlorothiazide\n* Use of any diuretic\n* Orthostatic hypotension complaints or blood pressure \\\u003C105\u002F65mmHg during screening visit\n* Uncontrolled hypertension (blood pressure \\>160\u002F100mmHg)\n* Hypokalemia (\\\u003C3.5 mmol\u002FL)\n* History of active gout on maintenance preventive treatment for gout (allopurinol, desuric and\u002For colchicine), defined as ≥2 episodes during the last year\n* History of skin cancer (basal cell, squamous cell and melanoma)","ALL","18 Years","80 Years",{"count":195,"type":196},300,"ESTIMATED","INTERVENTIONAL",[199],"PHASE3","Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive formation of renal cysts which ultimately lead to a loss of renal function.\n\nTolvaptan (a V2R antagonist) is currently the only effective treatment for preserving renal function in ADPKD. However, side-effects such as polyuria limit its tolerability and thereby the therapeutic potential. This study will test whether co-administration with hydochlorothiazide can improve V2RA efficacy (slowing kidney function decline) and tolerability (quality of life) in ADPKD. Approximately 300 patients will be enrolled.",[202],"ADPKD",[202,204,9,205,206,207],"Tolvaptan","Quality of Life","Side effects","Polyuria","2026-02-23",{"date":210,"type":211},"2026-02-25","ACTUAL",{"date":213,"type":211},"2024-07-31",{"date":215,"type":196},"2031-07",{"name":5,"class":6},12]