[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100374131":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":40,"centralContacts":44,"locations":49,"responsibleParty":65,"collaborators":30,"id":68,"slug":30,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":30,"eligibilityCriteria":73,"healthyVolunteers":69,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":30,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":87,"overallStatus":52,"whyStopped":30,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Second Affiliated Hospital, School of Medicine, Zhejiang University","OTHER",[8,15,20],{"label":9,"type":10,"description":11,"interventionNames":12},"90mg Idebenone","EXPERIMENTAL","Placebo by mouth, three times a day for 1 months； Idebenone 30mg table by mouth, three times a day for next 3 months",[13,14],"Drug: Placebo","Drug: 90mg Idebenone",{"label":16,"type":10,"description":17,"interventionNames":18},"270mg Idebenone","Placebo by mouth, three times a day for 1 months； Idebenone 90mg table by mouth, three times a day for next 3 months",[13,19],"Drug: 270mg Idebenone",{"label":21,"type":22,"description":23,"interventionNames":24},"Placebo","PLACEBO_COMPARATOR","Placebo by mouth, three times a day for 4 months",[13],[26,31,36],{"type":27,"name":21,"description":28,"armGroupLabels":29,"otherNames":30},"DRUG","Placebo oral tablet, three times a day",[16,9,21],null,{"type":27,"name":9,"description":32,"armGroupLabels":33,"otherNames":34},"Idebenone 30 MG Oral Tablet, three times a day",[9],[35],"Shenwei",{"type":27,"name":16,"description":37,"armGroupLabels":38,"otherNames":39},"Idebenone 90 MG Oral Tablet, three times a day",[16],[35],[41],{"name":42,"affiliation":5,"role":43},"Kaiming Liu, MD & PHD","STUDY_CHAIR",[45],{"name":42,"role":46,"phone":47,"phoneExt":30,"email":48},"CONTACT","+8615068862055","2314411@zju.edu.cn",[50],{"facility":51,"status":52,"city":53,"state":54,"zip":55,"country":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"Kaiming Liu","RECRUITING","Hangzhou","Zhejiang","370001","China",{"type":58,"coordinates":59},"Point",[60,61],120.16142,30.29365,{"lat":61,"lon":60},[64],{"name":51,"role":46,"phone":30,"phoneExt":30,"email":30},{"type":66,"investigatorFullName":51,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"PRINCIPAL_INVESTIGATOR","Deputy chief physician","100374131",false,"NCT04151472","Idebenone for the Preventive Treatment of Migraine","A Randomized, Double-blinded, Placebo-controlled Trial of Idebenone in the Prevention of Episodic Migraine","Inclusion Criteria:\n\n1. Clinical diagnosis of episodic migraine.\n2. Patients (18-65 years) were eligible if they met International Headache Society (IHS) criteria for episodic migraine with\u002F without aura with a migraine history 1 year\n3. Two to eight attacks per month, 5 days\u002Fmonth of interval headaches.\n4. No over consumption of acute anti-migraine medication.\n5. No other prophylactic medication (washout 3 months).\n6. No serious organic or psychiatric disease.\n7. Only women with contraceptive protection.\n\nExclusion Criteria:\n\n1. Clinical diagnosis of chronic migraine.\n2. Subjects previously discontinued idebenone due to adverse events.\n3. Subjects are taking idebenone or had taken idebenone within 14 days prior to enrollment.\n4. Subjects with continuous headaches.","ALL","18 Years","65 Years",{"count":78,"type":79},180,"ESTIMATED","INTERVENTIONAL",[82],"PHASE3","Idebenone improves energy metabolism similarly to Coenzyme Q10, which is effective in migraine prophylaxis. The investigators compare idebenone (90 mg\u002Fday, 270 mg\u002Fday) and placebo in 180 migraine patients in a double-blind, randomized, placebo-controlled, multicenter trial to study whether Idebenone is superior to placebo in the prevention of episodic migraine with or without aura.",[85,86],"Migraine Disorders","Headache Disorders",[88,89,90,91],"Migraine Prophylaxis","Mitochondrial Dysfunction","Idebenone","Individualized Treatment","2025-05-12",{"date":94,"type":95},"2025-05-15","ACTUAL",{"date":97,"type":95},"2021-12-08",{"date":99,"type":79},"2025-12-31",{"name":5,"class":6},1]