Letrozole for Estrogen/Progesterone Receptor Positive Low-grade Serous Epithelial Ovarian Cancer (LEPRE Trial)

Patients must have undergone contrast-enhanced CT-scan of the chest, abdomen and pelvis within 28 days prior to randomization. If CT-scan is not recommended (e.g. for allergy to contrast agent) MRI or 18F-FDG PET/CT-scan are allowed.

The imaging evaluation must be accompanied by an anamnestic and physical examination within 14 days prior to randomization.

Patients who underwent bilateral salpingo-oophorectomy;

Monolateral salpingo-oophorectomy, amenorrhea for 12 or more consecutive months and age ≥60 years;