[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100590345":3},{"organization":4,"outcomesModule":7,"designInfo":26,"detailedDescription":25,"studyPopulation":25,"armGroups":38,"interventions":51,"overallOfficials":61,"centralContacts":66,"locations":76,"responsibleParty":94,"collaborators":25,"id":97,"slug":25,"hasResults":98,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":102,"eligibilityCriteria":103,"healthyVolunteers":98,"sex":104,"minAge":105,"maxAge":25,"enrollmentInfo":106,"targetDuration":25,"studyType":109,"phases":110,"briefSummary":112,"conditions":113,"keywords":115,"overallStatus":78,"whyStopped":25,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":130},{"fullName":5,"class":6},"St. Joseph's Healthcare Hamilton","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":25},[9],{"measure":10,"description":11,"timeFrame":12},"Pain intensity","Average pain intensity will be measured using a 0-10 Numeric Rating Scale (NRS), where 0 represents \"no pain\" and 10 represents \"worst imaginable pain.\" Scores are collected before and after each treatment period. Higher scores indicate greater pain intensity and thus a worse outcome.","baseline [week 0] and weeks 2, 4, and 6",[14,18,21],{"measure":15,"description":16,"timeFrame":17},"Hand function","Measured using the Michigan Hand Outcomes Questionnaire (MHQ), a validated instrument assessing hand function, activities of daily living, work performance, pain, aesthetics, and patient satisfaction. The total score ranges from 0 to 100, with higher scores representing better overall hand function and patient-reported outcomes.","weeks 2, 4 and 6",{"measure":19,"description":20,"timeFrame":17},"Patients reported improvement","Measured using the Patient Global Impression of Change (PGIC) scale, a single-item, patient-reported measure of overall improvement. The scale ranges from 1 to 7, where 1 indicates \"very much improved\" and 7 indicates \"very much worse.\" Lower scores represent better outcomes.",{"measure":22,"description":23,"timeFrame":24},"Safety - adverse events","Hand-related and medication-related serious and non-serious adverse events","through study completion, an average of 6 weeks",null,{"allocation":27,"interventionModel":28,"interventionModelDescription":29,"primaryPurpose":30,"observationalModel":25,"timePerspective":25,"maskingInfo":31},"RANDOMIZED","CROSSOVER","2x2 crossover randomized placebo-controlled trial","TREATMENT",{"masking":32,"maskingDescription":25,"whoMasked":33},"QUADRUPLE",[34,35,36,37],"PARTICIPANT","CARE_PROVIDER","INVESTIGATOR","OUTCOMES_ASSESSOR",[39,45],{"label":40,"type":41,"description":42,"interventionNames":43},"Multiprofen-CC™","EXPERIMENTAL","Multiprofen-CC™ \\[ketoprofen (10%), baclofen (5%), amitriptyline (2%), and lidocaine (5%)\\] Dose: 1.0g, 3 times per day for 2 weeks",[44],"Drug: Multiprofen-CC™ plus standard treatment",{"label":46,"type":47,"description":48,"interventionNames":49},"Placebo","PLACEBO_COMPARATOR","The placebo is the base cream with no medicinal ingredients Dose: 1.0g, 3 times per day for 2 weeks",[50],"Other: Placebo plus standard treatment",[52,57],{"type":53,"name":54,"description":55,"armGroupLabels":56,"otherNames":25},"DRUG","Multiprofen-CC™ plus standard treatment","Standard care pain medications and topical Multiprofen-CC™ (1g TID) for 2 weeks",[40],{"type":6,"name":58,"description":59,"armGroupLabels":60,"otherNames":25},"Placebo plus standard treatment","Standard care pain medications and visually identical topical placebo (1g TID) for 2 weeks",[46],[62],{"name":63,"affiliation":64,"role":65},"Carolyn Levis, MD, MSc, FRCS(C)","McMaster University","PRINCIPAL_INVESTIGATOR",[67,72],{"name":68,"role":69,"phone":70,"phoneExt":25,"email":71},"Breanne Flood, MSc","CONTACT","905-870-1382","bflood@stjoes.ca",{"name":73,"role":69,"phone":74,"phoneExt":25,"email":75},"Kim Irish, BSW","365-336-7598","irishkd@mcmaster.ca",[77],{"facility":5,"status":78,"city":79,"state":80,"zip":81,"country":82,"countryCode":83,"cosmosGeoPoint":84,"geoPoint":89,"contacts":90},"RECRUITING","Hamilton","Ontario","L8N4A6","Canada","CA",{"type":85,"coordinates":86},"Point",[87,88],-79.84963,43.25011,{"lat":88,"lon":87},[91],{"name":68,"role":69,"phone":92,"phoneExt":25,"email":93},"9058701382","floodbl@mcmaster.ca",{"type":65,"investigatorFullName":95,"investigatorTitle":96,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Carolyn Levis","Principal Investigator","100590345",false,"NCT06966206","Multiprofen-CC to Reduce Pain in Hand Arthritis","Multiprofen-CC to Reduce Pain in Hand Arthritis (MRP-HAND): A Crossover Randomized Controlled Trial","MRP-HAND","Inclusion Criteria:\n\n* Adults (18+)\n* Have been diagnosed with hand osteoarthritis according to American College of Rheumatology criteria\n* Experience pain and\u002For loss of function in one or both hands that interferes with daily life\n* Provide informed consent\n\nExclusion Criteria:\n\n* Unable to consent\n* Unable or unwilling to follow study protocol\n* Known allergy or contraindication to any of the study drugs or their ingredients\n* Have open wounds\u002Fcuts and\u002For skin conditions on the hand area\n* Pregnant or breastfeeding\n* History of impaired kidney or liver function\n* Rheumatoid or other inflammatory arthropathy\n* Hand surgery within the past 6 months or planned within the study period.\n* Use daily opioids (other than short acting codeine) for a chronic pain condition other than hand arthritis","ALL","18 Years",{"count":107,"type":108},42,"ESTIMATED","INTERVENTIONAL",[111],"PHASE3","This clinical trial aims to find out if using 1 gram of Multiprofen-CC cream on the hands three times a day for 4 weeks can help reduce pain in adults with hand osteoarthritis, compared to a placebo (a cream with no active medicine). The research team will also look at how Multiprofen-CC affects hand function, opioid use, and how patients feel about their overall improvement. In addition, the research team will keep track of any side effects.\n\nParticipants will:\n\n* Use both Multiprofen-CC and a placebo (a cream with no active medicine) during the study, in a random order.\n* Be asked to apply 1 gram of cream to their hands three times a day for 2 weeks, following the manufacturer's instructions.\n* Attend a visit before starting the study, after 2 weeks, and after 6 weeks.\n* Report any symptoms they experience during the study.",[114],"Hand Osteoarthritis",[116,117,118,119,120],"hand osteoarthritis","osteoarthritis","arthritis","topical","multiprofen","2026-04-28",{"date":123,"type":124},"2026-05-04","ACTUAL",{"date":126,"type":124},"2026-03-09",{"date":128,"type":108},"2027-08-01",{"name":5,"class":6},1]