[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100594111":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":33,"centralContacts":34,"locations":43,"responsibleParty":1207,"collaborators":33,"id":1209,"slug":33,"hasResults":1210,"nctId":1211,"briefTitle":1212,"officialTitle":1213,"acronym":33,"eligibilityCriteria":1214,"healthyVolunteers":1210,"sex":1215,"minAge":1216,"maxAge":33,"enrollmentInfo":1217,"targetDuration":33,"studyType":1220,"phases":1221,"briefSummary":1223,"conditions":1224,"keywords":1226,"overallStatus":46,"whyStopped":33,"lastUpdateSubmitDate":1238,"lastUpdatePostDateStruct":1239,"startDateStruct":1242,"completionDateStruct":1244,"leadSponsor":1246,"locationsCount":1247},{"fullName":5,"class":6},"IDEAYA Biosciences","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Treatment Arm","EXPERIMENTAL","Darovasetib followed by definitive primary local therapy (i.e., PB, proton beam radiation, or enucleation)",[13],"Drug: Darovasertib",{"label":15,"type":16,"description":17,"interventionNames":18},"Control Arm","ACTIVE_COMPARATOR","Immediate Primary Local therapy",[19],"Procedure: Primary Local Therapy",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Darovasertib","Dosed orally, twice daily (28-day\u002F cycle",[9],[27],"IDE 196",{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"PROCEDURE","Primary Local Therapy","Plaque Brachytherapy or Enucleation",[15],null,[35,40],{"name":36,"role":37,"phone":38,"phoneExt":33,"email":39},"IDEAYA Clinical Trials","CONTACT","+1-855-433-2246","IDEAYAClinicalTrials@ideayabio.com",{"name":41,"role":37,"phone":33,"phoneExt":33,"email":42},"Mwe Mwe Chao, MD","mchao@ideayabio.com",[44,60,74,86,95,107,119,131,143,156,168,181,193,202,215,228,241,253,266,279,291,300,309,322,334,347,360,372,385,394,407,419,428,440,453,466,480,493,506,518,531,543,555,568,580,594,607,620,629,642,656,670,683,696,708,717,731,743,756,769,782,794,806,818,830,842,856,868,881,890,902,916,928,939,952,963,975,989,1002,1016,1029,1042,1055,1068,1082,1095,1108,1120,1132,1144,1157,1169,1183,1195],{"facility":45,"status":46,"city":47,"state":48,"zip":49,"country":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Mayo Clinic Scottsdale - PPDS","RECRUITING","Scottsdale","Arizona","85259","United States",{"type":52,"coordinates":53},"Point",[54,55],-111.89903,33.50921,{"lat":55,"lon":54},[58],{"name":59,"role":37,"phone":33,"phoneExt":33,"email":33},"Odette Houghton, MD Principal Investigator",{"facility":61,"status":62,"city":63,"state":64,"zip":65,"country":50,"cosmosGeoPoint":66,"geoPoint":70,"contacts":71},"UCSD Moores Cancer Center","NOT_YET_RECRUITING","La Jolla","California","92093",{"type":52,"coordinates":67},[68,69],-117.2742,32.84727,{"lat":69,"lon":68},[72],{"name":73,"role":37,"phone":33,"phoneExt":33,"email":33},"Gregory Daniels, MD Principal Investigator",{"facility":75,"status":62,"city":76,"state":64,"zip":77,"country":50,"cosmosGeoPoint":78,"geoPoint":82,"contacts":83},"Jules Stein Eye Institute","Los Angeles","90024",{"type":52,"coordinates":79},[80,81],-118.24368,34.05223,{"lat":81,"lon":80},[84],{"name":85,"role":37,"phone":33,"phoneExt":33,"email":33},"Tara McCannel, MD Principal Investigator",{"facility":87,"status":62,"city":76,"state":64,"zip":88,"country":50,"cosmosGeoPoint":89,"geoPoint":91,"contacts":92},"USC Norris Comprehensive Cancer Center","90033",{"type":52,"coordinates":90},[80,81],{"lat":81,"lon":80},[93],{"name":94,"role":37,"phone":33,"phoneExt":33,"email":33},"Gino In, MD, Principal Investigator",{"facility":96,"status":62,"city":97,"state":64,"zip":98,"country":50,"cosmosGeoPoint":99,"geoPoint":103,"contacts":104},"University of California Irvine Medical Center","Orange","92868",{"type":52,"coordinates":100},[101,102],-117.85311,33.78779,{"lat":102,"lon":101},[105],{"name":106,"role":37,"phone":33,"phoneExt":33,"email":33},"Poorva Vaidya, MD Principal Investigator",{"facility":108,"status":46,"city":109,"state":64,"zip":110,"country":50,"cosmosGeoPoint":111,"geoPoint":115,"contacts":116},"Stanford Comprehensive Cancer Center","Palo Alto","94304",{"type":52,"coordinates":112},[113,114],-122.14302,37.44188,{"lat":114,"lon":113},[117],{"name":118,"role":37,"phone":33,"phoneExt":33,"email":33},"Pauline Funchain, MD Principal Investigator",{"facility":120,"status":46,"city":121,"state":64,"zip":122,"country":50,"cosmosGeoPoint":123,"geoPoint":127,"contacts":128},"Kaiser Permanente-Riverside Medical Center","Riverside","92505-3043",{"type":52,"coordinates":124},[125,126],-117.39616,33.95335,{"lat":126,"lon":125},[129],{"name":130,"role":37,"phone":33,"phoneExt":33,"email":33},"Helen Moon, MD Principal Investigator",{"facility":132,"status":62,"city":133,"state":64,"zip":134,"country":50,"cosmosGeoPoint":135,"geoPoint":139,"contacts":140},"UCSF Wayne and Gladys Valley Center for Vision","San Francisco","94143",{"type":52,"coordinates":136},[137,138],-122.41942,37.77493,{"lat":138,"lon":137},[141],{"name":142,"role":37,"phone":33,"phoneExt":33,"email":33},"Armin Afshar, MD, Principal Investigator",{"facility":144,"status":46,"city":145,"state":146,"zip":147,"country":50,"cosmosGeoPoint":148,"geoPoint":152,"contacts":153},"University of Colorado Hospital","Aurora","Colorado","80045",{"type":52,"coordinates":149},[150,151],-104.83192,39.72943,{"lat":151,"lon":150},[154],{"name":155,"role":37,"phone":33,"phoneExt":33,"email":33},"Sapna Patel, MD Principal Investigator",{"facility":157,"status":62,"city":158,"state":146,"zip":159,"country":50,"cosmosGeoPoint":160,"geoPoint":164,"contacts":165},"The Melanoma and Skin Cancer Institute","Englewood","80113-2791",{"type":52,"coordinates":161},[162,163],-104.98776,39.64777,{"lat":163,"lon":162},[166],{"name":167,"role":37,"phone":33,"phoneExt":33,"email":33},"Ryan Weight, MD Principal Investigator",{"facility":169,"status":46,"city":170,"state":171,"zip":172,"country":50,"cosmosGeoPoint":173,"geoPoint":177,"contacts":178},"Mayo Clinic Jacksonville","Jacksonville","Florida","32224",{"type":52,"coordinates":174},[175,176],-81.65565,30.33218,{"lat":176,"lon":175},[179],{"name":180,"role":37,"phone":33,"phoneExt":33,"email":33},"Bently Doonan, MD Principal Investigator",{"facility":182,"status":62,"city":183,"state":171,"zip":184,"country":50,"cosmosGeoPoint":185,"geoPoint":189,"contacts":190},"USF Health Eye Institute","Tampa","33612-6601",{"type":52,"coordinates":186},[187,188],-82.45843,27.94752,{"lat":188,"lon":187},[191],{"name":192,"role":37,"phone":33,"phoneExt":33,"email":33},"Jorge Agi, MD Principal Investigator",{"facility":194,"status":62,"city":183,"state":171,"zip":195,"country":50,"cosmosGeoPoint":196,"geoPoint":198,"contacts":199},"Moffit Cancer Center","33612",{"type":52,"coordinates":197},[187,188],{"lat":188,"lon":187},[200],{"name":201,"role":37,"phone":33,"phoneExt":33,"email":33},"Nikhil Khushalani, MD, Principal Investigator",{"facility":203,"status":46,"city":204,"state":205,"zip":206,"country":50,"cosmosGeoPoint":207,"geoPoint":211,"contacts":212},"Wilmer Eye Institute","Baltimore","Maryland","21287-0005",{"type":52,"coordinates":208},[209,210],-76.61219,39.29038,{"lat":210,"lon":209},[213],{"name":214,"role":37,"phone":33,"phoneExt":33,"email":33},"James Handa, MD Principal Investigator",{"facility":216,"status":62,"city":217,"state":218,"zip":219,"country":50,"cosmosGeoPoint":220,"geoPoint":224,"contacts":225},"Massachusetts General Hospital","Boston","Massachusetts","02114",{"type":52,"coordinates":221},[222,223],-71.05977,42.35843,{"lat":223,"lon":222},[226],{"name":227,"role":37,"phone":33,"phoneExt":33,"email":33},"Kamaneh Montazeri, MD Principal Investigator",{"facility":229,"status":62,"city":230,"state":231,"zip":232,"country":50,"cosmosGeoPoint":233,"geoPoint":237,"contacts":238},"W Kellogg Eye Center","Ann Arbor","Michigan","48105",{"type":52,"coordinates":234},[235,236],-83.74088,42.27756,{"lat":236,"lon":235},[239],{"name":240,"role":37,"phone":33,"phoneExt":33,"email":33},"Hakan Demirci, MD Principal Investigator",{"facility":242,"status":46,"city":243,"state":231,"zip":244,"country":50,"cosmosGeoPoint":245,"geoPoint":249,"contacts":250},"The Cancer and Hematology Centers of West Michigan (CHCWM)","Grand Rapids","49503",{"type":52,"coordinates":246},[247,248],-85.66809,42.96336,{"lat":248,"lon":247},[251],{"name":252,"role":37,"phone":33,"phoneExt":33,"email":33},"Sreenivasa Chandana, MD Principal Investigator",{"facility":254,"status":46,"city":255,"state":256,"zip":257,"country":50,"cosmosGeoPoint":258,"geoPoint":262,"contacts":263},"Mayo Clinic - PPDS","Rochester","Minnesota","55905",{"type":52,"coordinates":259},[260,261],-92.4699,44.02163,{"lat":261,"lon":260},[264],{"name":265,"role":37,"phone":33,"phoneExt":33,"email":33},"Lauren Dalvin, MD Principal Investigator",{"facility":267,"status":62,"city":268,"state":269,"zip":270,"country":50,"cosmosGeoPoint":271,"geoPoint":275,"contacts":276},"TIERING Percentiles","Omaha","Nebraska","68105",{"type":52,"coordinates":272},[273,274],-95.94043,41.25626,{"lat":274,"lon":273},[277],{"name":278,"role":37,"phone":33,"phoneExt":33,"email":33},"Pukhraj Rishi, MD Principal Investigator",{"facility":280,"status":46,"city":281,"state":281,"zip":282,"country":50,"cosmosGeoPoint":283,"geoPoint":287,"contacts":288},"Herbert Irving Comprehensive Cancer Center","New York","10032",{"type":52,"coordinates":284},[285,286],-74.00597,40.71427,{"lat":286,"lon":285},[289],{"name":290,"role":37,"phone":33,"phoneExt":33,"email":33},"Benjamin Izar, MD Principal Investigator",{"facility":292,"status":62,"city":281,"state":281,"zip":293,"country":50,"cosmosGeoPoint":294,"geoPoint":296,"contacts":297},"Memorial Sloan Kettering Cancer Center - 1275 York Ave","10065-6635",{"type":52,"coordinates":295},[285,286],{"lat":286,"lon":285},[298],{"name":299,"role":37,"phone":33,"phoneExt":33,"email":33},"Jasmine Francis, MD Principal Investigator",{"facility":301,"status":62,"city":281,"state":281,"zip":302,"country":50,"cosmosGeoPoint":303,"geoPoint":305,"contacts":306},"Northwell Health Cancer Institute","11042",{"type":52,"coordinates":304},[285,286],{"lat":286,"lon":285},[307],{"name":308,"role":37,"phone":33,"phoneExt":33,"email":33},"Shaheer Khan, MD Principal Investigator",{"facility":310,"status":62,"city":311,"state":312,"zip":313,"country":50,"cosmosGeoPoint":314,"geoPoint":318,"contacts":319},"Cole Eye Institute-9500 Euclid Ave","Cleveland","Ohio","44195",{"type":52,"coordinates":315},[316,317],-81.69541,41.4995,{"lat":317,"lon":316},[320],{"name":321,"role":37,"phone":33,"phoneExt":33,"email":33},"Lucy Kennedy, MD Principal Investigator",{"facility":323,"status":62,"city":324,"state":312,"zip":325,"country":50,"cosmosGeoPoint":326,"geoPoint":330,"contacts":331},"Ohio State Eye and Ear Institute","Columbus","43212",{"type":52,"coordinates":327},[328,329],-82.99879,39.96118,{"lat":329,"lon":328},[332],{"name":333,"role":37,"phone":33,"phoneExt":33,"email":33},"Colleen Cebulla, MD Principal Investigator",{"facility":335,"status":62,"city":336,"state":337,"zip":338,"country":50,"cosmosGeoPoint":339,"geoPoint":343,"contacts":344},"Retina Consultants of Oklahoma","Oklahoma City","Oklahoma","73112",{"type":52,"coordinates":340},[341,342],-97.51643,35.46756,{"lat":342,"lon":341},[345],{"name":346,"role":37,"phone":33,"phoneExt":33,"email":33},"Brian Firestone, MD, Principal Investigator",{"facility":348,"status":62,"city":349,"state":350,"zip":351,"country":50,"cosmosGeoPoint":352,"geoPoint":356,"contacts":357},"Jefferson Health Honickman Center","Philadelphia","Pennsylvania","19107",{"type":52,"coordinates":353},[354,355],-75.16362,39.95238,{"lat":355,"lon":354},[358],{"name":359,"role":37,"phone":33,"phoneExt":33,"email":33},"Marlana Orloff, MD Principal Investigator",{"facility":361,"status":62,"city":362,"state":350,"zip":363,"country":50,"cosmosGeoPoint":364,"geoPoint":368,"contacts":369},"UPMC Hillman Cancer Center","Pittsburgh","15232",{"type":52,"coordinates":365},[366,367],-79.99589,40.44062,{"lat":367,"lon":366},[370],{"name":371,"role":37,"phone":33,"phoneExt":33,"email":33},"Yana Najjar, MD Principal Investigator",{"facility":373,"status":46,"city":374,"state":375,"zip":376,"country":50,"cosmosGeoPoint":377,"geoPoint":381,"contacts":382},"SCRI Oncology Partners","Nashville","Tennessee","37203",{"type":52,"coordinates":378},[379,380],-86.78444,36.16589,{"lat":380,"lon":379},[383],{"name":384,"role":37,"phone":33,"phoneExt":33,"email":33},"Meredith McKean, MD Principal Investigator",{"facility":386,"status":62,"city":374,"state":375,"zip":387,"country":50,"cosmosGeoPoint":388,"geoPoint":390,"contacts":391},"Vanderbilt Eye Institute","37232",{"type":52,"coordinates":389},[379,380],{"lat":380,"lon":379},[392],{"name":393,"role":37,"phone":33,"phoneExt":33,"email":33},"Paul Sternberg, MD, Principal Investigator",{"facility":395,"status":46,"city":396,"state":397,"zip":398,"country":50,"cosmosGeoPoint":399,"geoPoint":403,"contacts":404},"Austin Retina Associates - Central","Austin","Texas","78705",{"type":52,"coordinates":400},[401,402],-97.74306,30.26715,{"lat":402,"lon":401},[405],{"name":406,"role":37,"phone":33,"phoneExt":33,"email":33},"Shelley Ghafoori, MD Principal Investigator",{"facility":408,"status":46,"city":409,"state":397,"zip":410,"country":50,"cosmosGeoPoint":411,"geoPoint":415,"contacts":416},"Texas Retina Associates - Dallas","Dallas","75231",{"type":52,"coordinates":412},[413,414],-96.80667,32.78306,{"lat":414,"lon":413},[417],{"name":418,"role":37,"phone":33,"phoneExt":33,"email":33},"Timothy Fuller, MD Principal Investigator",{"facility":420,"status":46,"city":409,"state":397,"zip":421,"country":50,"cosmosGeoPoint":422,"geoPoint":424,"contacts":425},"University of Texas Southwestern Medical Center-5323 Harry Hines Blvd","75390-9057",{"type":52,"coordinates":423},[413,414],{"lat":414,"lon":413},[426],{"name":427,"role":37,"phone":33,"phoneExt":33,"email":33},"Sanjay Chandrasekaran, MD Principal Investigator",{"facility":429,"status":62,"city":430,"state":397,"zip":431,"country":50,"cosmosGeoPoint":432,"geoPoint":436,"contacts":437},"Retina Consultants of Texas - (Houston)","Houston","77030-2727",{"type":52,"coordinates":433},[434,435],-95.36327,29.76328,{"lat":435,"lon":434},[438],{"name":439,"role":37,"phone":33,"phoneExt":33,"email":33},"Amy Schefler, MD Principal Investigator",{"facility":441,"status":62,"city":442,"state":443,"zip":444,"country":50,"cosmosGeoPoint":445,"geoPoint":449,"contacts":450},"Augusta Health, Center for Cancer and Blood Disorders","Fishersville","Virginia","22939",{"type":52,"coordinates":446},[447,448],-78.96919,38.09902,{"lat":448,"lon":447},[451],{"name":452,"role":37,"phone":33,"phoneExt":33,"email":33},"Kelvin Rayborn, MD Principal Investigator",{"facility":454,"status":62,"city":455,"state":456,"zip":457,"country":50,"cosmosGeoPoint":458,"geoPoint":462,"contacts":463},"University of Wisconsin Health","Madison","Wisconsin","53705-3644",{"type":52,"coordinates":459},[460,461],-89.40123,43.07305,{"lat":461,"lon":460},[464],{"name":465,"role":37,"phone":33,"phoneExt":33,"email":33},"Michael Altaweel, MD Principal Investigator",{"facility":467,"status":62,"city":468,"state":469,"zip":470,"country":471,"cosmosGeoPoint":472,"geoPoint":476,"contacts":477},"Gallipoli Medical Research Foundation","Greenslopes","Queensland","QLD 4120","Australia",{"type":52,"coordinates":473},[474,475],153.04951,-27.50815,{"lat":475,"lon":474},[478],{"name":479,"role":37,"phone":33,"phoneExt":33,"email":33},"Victoria Atkinson, MD, Principal Investigator",{"facility":481,"status":62,"city":482,"state":483,"zip":484,"country":471,"cosmosGeoPoint":485,"geoPoint":489,"contacts":490},"The Queen Elizabeth Hospital","Woodville South","South Australia","5011",{"type":52,"coordinates":486},[487,488],138.53477,-34.88186,{"lat":488,"lon":487},[491],{"name":492,"role":37,"phone":33,"phoneExt":33,"email":33},"Rachel Roberts-Thomson, MD Principal Investigator",{"facility":494,"status":62,"city":495,"state":496,"zip":497,"country":471,"cosmosGeoPoint":498,"geoPoint":502,"contacts":503},"The Alfred Hospital","Melbourne","Victoria","3004",{"type":52,"coordinates":499},[500,501],144.96332,-37.814,{"lat":501,"lon":500},[504],{"name":505,"role":37,"phone":33,"phoneExt":33,"email":33},"Mark Shackleton, MD Principal Investigator",{"facility":507,"status":62,"city":508,"state":33,"zip":509,"country":471,"cosmosGeoPoint":510,"geoPoint":514,"contacts":515},"The Crown Princess Mary Cancer Centre (Westmead Hospital), NSW 214","Westmead","NSW 2145",{"type":52,"coordinates":511},[512,513],150.98768,-33.80383,{"lat":513,"lon":512},[516],{"name":517,"role":37,"phone":33,"phoneExt":33,"email":33},"Matteo Carlino, MD, Principal Investigator",{"facility":519,"status":62,"city":520,"state":33,"zip":521,"country":522,"cosmosGeoPoint":523,"geoPoint":527,"contacts":528},"LKH-Universitätsklinikum Graz","Graz","8036","Austria",{"type":52,"coordinates":524},[525,526],15.44197,47.06733,{"lat":526,"lon":525},[529],{"name":530,"role":37,"phone":33,"phoneExt":33,"email":33},"Thomas Georgi, MD Principal Investigator",{"facility":532,"status":62,"city":533,"state":33,"zip":534,"country":522,"cosmosGeoPoint":535,"geoPoint":539,"contacts":540},"Universitätsklinikum Innsbruck","Innsbruck","6020",{"type":52,"coordinates":536},[537,538],11.39454,47.26266,{"lat":538,"lon":537},[541],{"name":542,"role":37,"phone":33,"phoneExt":33,"email":33},"Matus Rehak, MD Principal Investigator",{"facility":544,"status":62,"city":545,"state":33,"zip":546,"country":522,"cosmosGeoPoint":547,"geoPoint":551,"contacts":552},"Universitätsklinikum AKH Wien","Vienna","1090",{"type":52,"coordinates":548},[549,550],16.37208,48.20849,{"lat":550,"lon":549},[553],{"name":554,"role":37,"phone":33,"phoneExt":33,"email":33},"Roman Dunavölgyi, MD Principal Investigator",{"facility":556,"status":46,"city":557,"state":33,"zip":558,"country":559,"cosmosGeoPoint":560,"geoPoint":564,"contacts":565},"Cliniques Universitaires Saint-Luc - PPDS","Brussels","1200","Belgium",{"type":52,"coordinates":561},[562,563],4.34878,50.85045,{"lat":563,"lon":562},[566],{"name":567,"role":37,"phone":33,"phoneExt":33,"email":33},"Jean-Francois Baurain, MD Principal Investigator",{"facility":569,"status":62,"city":570,"state":33,"zip":571,"country":559,"cosmosGeoPoint":572,"geoPoint":576,"contacts":577},"UZ Leuven - PPDS","Leuven","3000",{"type":52,"coordinates":573},[574,575],4.70093,50.87959,{"lat":575,"lon":574},[578],{"name":579,"role":37,"phone":33,"phoneExt":33,"email":33},"Joachim Van Calster, MD Principal Investigator",{"facility":581,"status":62,"city":582,"state":583,"zip":584,"country":585,"cosmosGeoPoint":586,"geoPoint":590,"contacts":591},"Cross Cancer Institute","Edmonton","Alberta","T6G 1Z2","Canada",{"type":52,"coordinates":587},[588,589],-113.46871,53.55014,{"lat":589,"lon":588},[592],{"name":593,"role":37,"phone":33,"phoneExt":33,"email":33},"John Walker, MD, Principal Investigator",{"facility":595,"status":46,"city":596,"state":597,"zip":598,"country":585,"cosmosGeoPoint":599,"geoPoint":603,"contacts":604},"Princess Margaret Cancer Centre","Toronto","Ontario","M5G 2M9",{"type":52,"coordinates":600},[601,602],-79.39864,43.70643,{"lat":602,"lon":601},[605],{"name":606,"role":37,"phone":33,"phoneExt":33,"email":33},"Marcus Butler, MD Principal Investigator",{"facility":608,"status":46,"city":609,"state":609,"zip":610,"country":611,"cosmosGeoPoint":612,"geoPoint":616,"contacts":617},"Ustredni vojenska nemocnice - Vojenska fakultni nemocnice Praha","Prague","169 02","Czechia",{"type":52,"coordinates":613},[614,615],14.42076,50.08804,{"lat":615,"lon":614},[618],{"name":619,"role":37,"phone":33,"phoneExt":33,"email":33},"Zuzana Hradcova, MD Principal Investigator",{"facility":621,"status":62,"city":622,"state":623,"zip":624,"country":625,"cosmosGeoPoint":33,"geoPoint":33,"contacts":626},"Rigshospitalet","Copenhagen O","Capital","2100","Denmark",[627],{"name":628,"role":37,"phone":33,"phoneExt":33,"email":33},"Jens Kiilgaard, MD Principal Investigator",{"facility":630,"status":62,"city":631,"state":632,"zip":633,"country":625,"cosmosGeoPoint":634,"geoPoint":638,"contacts":639},"Aarhus Universitetshospital","Aarhus","Central Jutland","8200",{"type":52,"coordinates":635},[636,637],10.21076,56.15674,{"lat":637,"lon":636},[640],{"name":641,"role":37,"phone":33,"phoneExt":33,"email":33},"Peter Skov Jensen, MD Principal Investigator",{"facility":643,"status":62,"city":644,"state":645,"zip":646,"country":647,"cosmosGeoPoint":648,"geoPoint":652,"contacts":653},"East Tallinn Central Hospital-Pärnu road 104","Tallinn","Harju","11312","Estonia",{"type":52,"coordinates":649},[650,651],24.75353,59.43696,{"lat":651,"lon":650},[654],{"name":655,"role":37,"phone":33,"phoneExt":33,"email":33},"Elen Vettus, MD Principal Investigator",{"facility":657,"status":62,"city":658,"state":659,"zip":660,"country":661,"cosmosGeoPoint":662,"geoPoint":666,"contacts":667},"CHU de Nice-Hôpital Pasteur","Nice","Alpes-Maritimes","6000","France",{"type":52,"coordinates":663},[664,665],7.26608,43.70313,{"lat":665,"lon":664},[668],{"name":669,"role":37,"phone":33,"phoneExt":33,"email":33},"Sacha Nahon-Estève, MD Principal Investigator",{"facility":671,"status":62,"city":672,"state":673,"zip":674,"country":661,"cosmosGeoPoint":675,"geoPoint":679,"contacts":680},"Centre Retine Gallien - Bordeaux","Bordeaux","Gironde","33000",{"type":52,"coordinates":676},[677,678],-0.58046,44.84124,{"lat":678,"lon":677},[681],{"name":682,"role":37,"phone":33,"phoneExt":33,"email":33},"Laurence Rosier, MD Principal Investigator",{"facility":684,"status":62,"city":685,"state":686,"zip":687,"country":661,"cosmosGeoPoint":688,"geoPoint":692,"contacts":693},"CHU de Rennes - Hôpital Pontchaillou","Rennes","Ille-et-Vilaine","35000",{"type":52,"coordinates":689},[690,691],-1.67431,48.11109,{"lat":691,"lon":690},[694],{"name":695,"role":37,"phone":33,"phoneExt":33,"email":33},"Frederic Mouriaux, MD Principal Investigator",{"facility":697,"status":62,"city":698,"state":698,"zip":699,"country":661,"cosmosGeoPoint":700,"geoPoint":704,"contacts":705},"Institut Curie - Hôpital de Paris","Paris","75248",{"type":52,"coordinates":701},[702,703],2.3488,48.85341,{"lat":703,"lon":702},[706],{"name":707,"role":37,"phone":33,"phoneExt":33,"email":33},"Alexandre Matet, MD Principal Investigator",{"facility":709,"status":62,"city":698,"state":33,"zip":710,"country":661,"cosmosGeoPoint":711,"geoPoint":713,"contacts":714},"Centre Hospitalier National D'ophtalmologie Des Quinze Vingts","75571",{"type":52,"coordinates":712},[702,703],{"lat":703,"lon":702},[715],{"name":716,"role":37,"phone":33,"phoneExt":33,"email":33},"Sarah Tick, MD Principal Investigator",{"facility":718,"status":62,"city":719,"state":720,"zip":721,"country":722,"cosmosGeoPoint":723,"geoPoint":727,"contacts":728},"Universitätsklinikum Tübingen","Tübingen","Baden-Wurttemberg","72076","Germany",{"type":52,"coordinates":724},[725,726],9.05222,48.52266,{"lat":726,"lon":725},[729],{"name":730,"role":37,"phone":33,"phoneExt":33,"email":33},"Daniela Süsskind, MD Principal Investigator",{"facility":732,"status":62,"city":733,"state":720,"zip":734,"country":722,"cosmosGeoPoint":735,"geoPoint":739,"contacts":740},"Universitätsklinikum Ulm","Ulm","89075",{"type":52,"coordinates":736},[737,738],9.99155,48.39841,{"lat":738,"lon":737},[741],{"name":742,"role":37,"phone":33,"phoneExt":33,"email":33},"Armin Wolf, MD Principal Investigator",{"facility":744,"status":62,"city":745,"state":746,"zip":747,"country":722,"cosmosGeoPoint":748,"geoPoint":752,"contacts":753},"Hautklinik Erlangen","Erlangen","Bavaria","91054",{"type":52,"coordinates":749},[750,751],11.00783,49.59099,{"lat":751,"lon":750},[754],{"name":755,"role":37,"phone":33,"phoneExt":33,"email":33},"Carola Berking, MD Principal Investigator",{"facility":757,"status":62,"city":758,"state":759,"zip":760,"country":722,"cosmosGeoPoint":761,"geoPoint":765,"contacts":766},"Universitätsklinikum Essen","Essen","North Rhine-Westphalia","45147",{"type":52,"coordinates":762},[763,764],7.01228,51.45657,{"lat":764,"lon":763},[767],{"name":768,"role":37,"phone":33,"phoneExt":33,"email":33},"Halime Kalkavan, MD Principal Investigator",{"facility":770,"status":62,"city":771,"state":772,"zip":773,"country":722,"cosmosGeoPoint":774,"geoPoint":778,"contacts":779},"Städtisches Klinikum Dessau","Dessau","Saxony-Anhalt","6847",{"type":52,"coordinates":775},[776,777],12.24555,51.83864,{"lat":777,"lon":776},[780],{"name":781,"role":37,"phone":33,"phoneExt":33,"email":33},"Lothar Krause, MD Principal Investigator",{"facility":783,"status":62,"city":784,"state":33,"zip":785,"country":722,"cosmosGeoPoint":786,"geoPoint":790,"contacts":791},"Charité - Universitätsmedizin Berlin","Berlin","12203",{"type":52,"coordinates":787},[788,789],13.41053,52.52437,{"lat":789,"lon":788},[792],{"name":793,"role":37,"phone":33,"phoneExt":33,"email":33},"Antonia Joussen, MD Principal Investigator",{"facility":795,"status":62,"city":796,"state":33,"zip":797,"country":722,"cosmosGeoPoint":798,"geoPoint":802,"contacts":803},"Universitätsklinikum Bonn","Bonn","53127",{"type":52,"coordinates":799},[800,801],7.09549,50.73438,{"lat":801,"lon":800},[804],{"name":805,"role":37,"phone":33,"phoneExt":33,"email":33},"Thomas Ach, MD Principal Investigator",{"facility":807,"status":62,"city":808,"state":33,"zip":809,"country":722,"cosmosGeoPoint":810,"geoPoint":814,"contacts":815},"Universitätsklinikum Schleswig-Holstein - Campus Lübeck","Lübeck","23562",{"type":52,"coordinates":811},[812,813],10.68729,53.86893,{"lat":813,"lon":812},[816],{"name":817,"role":37,"phone":33,"phoneExt":33,"email":33},"Svenja Sonntag, Principal Investigator, MD",{"facility":819,"status":62,"city":820,"state":33,"zip":821,"country":722,"cosmosGeoPoint":822,"geoPoint":826,"contacts":827},"Universitätsklinikum Giessen und Marburg - Marburg (UKGM)","Marburg","35043",{"type":52,"coordinates":823},[824,825],8.77069,50.80904,{"lat":825,"lon":824},[828],{"name":829,"role":37,"phone":33,"phoneExt":33,"email":33},"Walter Sekundo, MD Principal Investigator",{"facility":831,"status":62,"city":832,"state":33,"zip":833,"country":722,"cosmosGeoPoint":834,"geoPoint":838,"contacts":839},"Universitätsklinikum Würzburg","Würzburg","97080",{"type":52,"coordinates":835},[836,837],9.95121,49.79391,{"lat":837,"lon":836},[840],{"name":841,"role":37,"phone":33,"phoneExt":33,"email":33},"Andreas Berlin, MD Principal Investigator",{"facility":843,"status":62,"city":844,"state":845,"zip":846,"country":847,"cosmosGeoPoint":848,"geoPoint":852,"contacts":853},"PAGNI-University General Hospital of Heraklion","Heraklion","Irakleio","715 00","Greece",{"type":52,"coordinates":849},[850,851],25.14341,35.32787,{"lat":851,"lon":850},[854],{"name":855,"role":37,"phone":33,"phoneExt":33,"email":33},"Efstathios Detorakis, MD Principal Investigator",{"facility":857,"status":62,"city":858,"state":858,"zip":859,"country":847,"cosmosGeoPoint":860,"geoPoint":864,"contacts":865},"University General Hospital of Larissa","Larissa","41 110",{"type":52,"coordinates":861},[862,863],22.42112,39.62847,{"lat":863,"lon":862},[866],{"name":867,"role":37,"phone":33,"phoneExt":33,"email":33},"Sofia Androudi, MD Principal Investigator",{"facility":869,"status":62,"city":870,"state":871,"zip":872,"country":847,"cosmosGeoPoint":873,"geoPoint":877,"contacts":878},"AHEPA University General Hospital of Thessaloniki","Thessaloniki","Thessaloníki","546 36",{"type":52,"coordinates":874},[875,876],22.93493,40.64072,{"lat":876,"lon":875},[879],{"name":880,"role":37,"phone":33,"phoneExt":33,"email":33},"Konstantinos Boboridis, MD Principal Investigator",{"facility":882,"status":46,"city":883,"state":884,"zip":885,"country":886,"cosmosGeoPoint":33,"geoPoint":33,"contacts":887},"The Chaim Sheba Medical Center - PPDS","Ramat Gan","Central District","5262100","Israel",[888],{"name":889,"role":37,"phone":33,"phoneExt":33,"email":33},"Vicktoria Vishnevskia-Dai, MD Principal Investigator",{"facility":891,"status":46,"city":892,"state":892,"zip":893,"country":886,"cosmosGeoPoint":894,"geoPoint":898,"contacts":899},"Hadassah Medical Center - PPDS","Jerusalem","91120",{"type":52,"coordinates":895},[896,897],35.21633,31.76904,{"lat":897,"lon":896},[900],{"name":901,"role":37,"phone":33,"phoneExt":33,"email":33},"Shahar Frenkel, MD Principal Investigator",{"facility":903,"status":62,"city":904,"state":905,"zip":906,"country":907,"cosmosGeoPoint":908,"geoPoint":912,"contacts":913},"Istituto Nazionale Tumori IRCCS Fondazione Giovanni Pascale","Naples","Campania","80131","Italy",{"type":52,"coordinates":909},[910,911],14.26811,40.85216,{"lat":911,"lon":910},[914],{"name":915,"role":37,"phone":33,"phoneExt":33,"email":33},"Paolo Ascierto, MD Principal Investigator",{"facility":917,"status":62,"city":918,"state":918,"zip":919,"country":907,"cosmosGeoPoint":920,"geoPoint":924,"contacts":925},"ASST Fatebenefratelli Sacco - Ospedale Luigi Sacco","Milan","20157",{"type":52,"coordinates":921},[922,923],12.59836,42.78235,{"lat":923,"lon":922},[926],{"name":927,"role":37,"phone":33,"phoneExt":33,"email":33},"Marco Pellegrini, MD Principal Investigator",{"facility":929,"status":62,"city":930,"state":930,"zip":33,"country":907,"cosmosGeoPoint":931,"geoPoint":935,"contacts":936},"Azienda Ospedaliera di Perugia - Ospedale Santa Maria della Misericordia","Perugia",{"type":52,"coordinates":932},[933,934],12.38878,43.1122,{"lat":934,"lon":933},[937],{"name":938,"role":37,"phone":33,"phoneExt":33,"email":33},"Mario Mandalà, MD Principal Investigator",{"facility":940,"status":46,"city":941,"state":942,"zip":943,"country":907,"cosmosGeoPoint":944,"geoPoint":948,"contacts":949},"Azienda Ospedaliera Universitaria Careggi","Florence","Tuscany","50134",{"type":52,"coordinates":945},[946,947],11.24626,43.77925,{"lat":947,"lon":946},[950],{"name":951,"role":37,"phone":33,"phoneExt":33,"email":33},"Cinzia Mazzini, MD Principal Investigator",{"facility":929,"status":62,"city":953,"state":33,"zip":954,"country":907,"cosmosGeoPoint":955,"geoPoint":959,"contacts":960},"Pisa","56124",{"type":52,"coordinates":956},[957,958],10.4036,43.70853,{"lat":958,"lon":957},[961],{"name":962,"role":37,"phone":33,"phoneExt":33,"email":33},"Federica Genovesi Ebert, MD Principal Investigator",{"facility":964,"status":62,"city":965,"state":33,"zip":966,"country":907,"cosmosGeoPoint":967,"geoPoint":971,"contacts":972},"Fondazione Policlinico Universitario A Gemelli - Rome - PPDS","Rome","168",{"type":52,"coordinates":968},[969,970],12.51133,41.89193,{"lat":970,"lon":969},[973],{"name":974,"role":37,"phone":33,"phoneExt":33,"email":33},"Ernesto Rossi, MD Principal Investigator",{"facility":976,"status":62,"city":977,"state":978,"zip":979,"country":980,"cosmosGeoPoint":981,"geoPoint":985,"contacts":986},"Erasmus MC","Rotterdam","South Holland","3015 GD","Netherlands",{"type":52,"coordinates":982},[983,984],4.47917,51.9225,{"lat":984,"lon":983},[987],{"name":988,"role":37,"phone":33,"phoneExt":33,"email":33},"Emine Kiliç-Ciğirci, MD Principal Investigator",{"facility":990,"status":62,"city":991,"state":991,"zip":992,"country":993,"cosmosGeoPoint":994,"geoPoint":998,"contacts":999},"Auckland Eye","Auckland","1050","New Zealand",{"type":52,"coordinates":995},[996,997],174.76349,-36.84853,{"lat":997,"lon":996},[1000],{"name":1001,"role":37,"phone":33,"phoneExt":33,"email":33},"Riyaz Bhikoo, MD Principal Investigator",{"facility":1003,"status":62,"city":1004,"state":1005,"zip":1006,"country":1007,"cosmosGeoPoint":1008,"geoPoint":1012,"contacts":1013},"Uniwersytecki Szpital Kliniczny w Poznaniu- Dluga 1\u002F2","Poznan","Greater Poland Voivodeship","61-848","Poland",{"type":52,"coordinates":1009},[1010,1011],16.92993,52.40692,{"lat":1011,"lon":1010},[1014],{"name":1015,"role":37,"phone":33,"phoneExt":33,"email":33},"Iwona Rospond-Kubiak, MD Principal Investigator",{"facility":1017,"status":62,"city":1018,"state":1019,"zip":1020,"country":1007,"cosmosGeoPoint":1021,"geoPoint":1025,"contacts":1026},"WIM-PIB, Centralny Szpital Kliniczny MON","Warsaw","Masovian Voivodeship","04-141",{"type":52,"coordinates":1022},[1023,1024],21.01178,52.22977,{"lat":1024,"lon":1023},[1027],{"name":1028,"role":37,"phone":33,"phoneExt":33,"email":33},"Izabela Nowak-Gospodarowicz, MD Principal Investigator",{"facility":1030,"status":62,"city":1031,"state":1032,"zip":1033,"country":1007,"cosmosGeoPoint":1034,"geoPoint":1038,"contacts":1039},"Uniwersyteckie Centrum Kliniczne w Gdansku - Debinki 7","Gdansk","Pomeranian Voivodeship","80-214",{"type":52,"coordinates":1035},[1036,1037],18.64912,54.35227,{"lat":1037,"lon":1036},[1040],{"name":1041,"role":37,"phone":33,"phoneExt":33,"email":33},"Kamil Drucis, MD Principal Investigator",{"facility":1043,"status":62,"city":1044,"state":33,"zip":1045,"country":1046,"cosmosGeoPoint":1047,"geoPoint":1051,"contacts":1052},"Fakultna nemocnica s poliklinikou F. D. Roosevelta","Banská Bystrica","975 17","Slovakia",{"type":52,"coordinates":1048},[1049,1050],19.14932,48.73947,{"lat":1050,"lon":1049},[1053],{"name":1054,"role":37,"phone":33,"phoneExt":33,"email":33},"Ladislav Janco, MD Principal Investigator",{"facility":1056,"status":62,"city":1057,"state":1057,"zip":1058,"country":1059,"cosmosGeoPoint":1060,"geoPoint":1064,"contacts":1065},"Institute of Oncology Ljubljana","Ljubljana","1000","Slovenia",{"type":52,"coordinates":1061},[1062,1063],14.50513,46.05108,{"lat":1063,"lon":1062},[1066],{"name":1067,"role":37,"phone":33,"phoneExt":33,"email":33},"Janja Ocvirk, MD Principal Investiagtor",{"facility":1069,"status":46,"city":1070,"state":1071,"zip":1072,"country":1073,"cosmosGeoPoint":1074,"geoPoint":1078,"contacts":1079},"Hospital Clinico Universitario de Santiago","Santiago de Compostela","A Coruña","15706","Spain",{"type":52,"coordinates":1075},[1076,1077],-8.54569,42.88052,{"lat":1077,"lon":1076},[1080],{"name":1081,"role":37,"phone":33,"phoneExt":33,"email":33},"Maria José Blanco Teijeiro, MD Principal Investigator",{"facility":1083,"status":62,"city":1084,"state":1085,"zip":1086,"country":1073,"cosmosGeoPoint":1087,"geoPoint":1091,"contacts":1092},"Hospital Universitario de Bellvitge","L'Hospitalet de Llobregat","Barcelona","8907",{"type":52,"coordinates":1088},[1089,1090],2.10028,41.35967,{"lat":1090,"lon":1089},[1093],{"name":1094,"role":37,"phone":33,"phoneExt":33,"email":33},"Jose Maria Caminal Mitjana, MD Principal Investigator",{"facility":1096,"status":46,"city":1097,"state":1098,"zip":1099,"country":1073,"cosmosGeoPoint":1100,"geoPoint":1104,"contacts":1105},"Clinica Universidad Navarra","Pamplona","Navarre","31008",{"type":52,"coordinates":1101},[1102,1103],-1.64323,42.81687,{"lat":1103,"lon":1102},[1106],{"name":1107,"role":37,"phone":33,"phoneExt":33,"email":33},"Alfredo Garcia Layana, MD Principal Investigator",{"facility":1109,"status":62,"city":1110,"state":1110,"zip":1111,"country":1073,"cosmosGeoPoint":1112,"geoPoint":1116,"contacts":1117},"Hospital Universitari i Politecnic La Fe de Valencia","Valencia","46026",{"type":52,"coordinates":1113},[1114,1115],-0.37966,39.47391,{"lat":1115,"lon":1114},[1118],{"name":1119,"role":37,"phone":33,"phoneExt":33,"email":33},"Rafael Martínez-Costa Pérez, MD Principal Investigator",{"facility":1121,"status":46,"city":1122,"state":1122,"zip":1123,"country":1073,"cosmosGeoPoint":1124,"geoPoint":1128,"contacts":1129},"Hospital Clinico Universitario de Valladolid","Valladolid","47003",{"type":52,"coordinates":1125},[1126,1127],-4.72353,41.65541,{"lat":1127,"lon":1126},[1130],{"name":1131,"role":37,"phone":33,"phoneExt":33,"email":33},"Ciro Garcia-Alvarez, MD Principal Investigator",{"facility":1133,"status":46,"city":1134,"state":33,"zip":1135,"country":1073,"cosmosGeoPoint":1136,"geoPoint":1140,"contacts":1141},"Hospital Universitario Virgen Macarena","Seville","41009",{"type":52,"coordinates":1137},[1138,1139],-5.97317,37.38283,{"lat":1139,"lon":1138},[1142],{"name":1143,"role":37,"phone":33,"phoneExt":33,"email":33},"Francisco Espejo-Arjona, MD Principal Investigator",{"facility":1145,"status":46,"city":1146,"state":33,"zip":1147,"country":1148,"cosmosGeoPoint":1149,"geoPoint":1153,"contacts":1154},"Universitätsspital Basel","Basel","4031","Switzerland",{"type":52,"coordinates":1150},[1151,1152],7.57327,47.55839,{"lat":1152,"lon":1151},[1155],{"name":1156,"role":37,"phone":33,"phoneExt":33,"email":33},"Andreas Schmitt, MD Principal Investigator",{"facility":1158,"status":46,"city":1159,"state":33,"zip":1160,"country":1148,"cosmosGeoPoint":1161,"geoPoint":1165,"contacts":1166},"Universitätsspital Zürich","Zurich","8091",{"type":52,"coordinates":1162},[1163,1164],8.55,47.36667,{"lat":1164,"lon":1163},[1167],{"name":1168,"role":37,"phone":33,"phoneExt":33,"email":33},"Egle Ramelyte, MD Principal Investigator",{"facility":1170,"status":62,"city":1171,"state":1172,"zip":1173,"country":1174,"cosmosGeoPoint":1175,"geoPoint":1179,"contacts":1180},"Clatterbridge Cancer Centre - Liverpool - NWCRN - PPDS","Metropolitan Borough of Wirral","Merseyside","CH63 4JY","United Kingdom",{"type":52,"coordinates":1176},[1177,1178],-3.10501,53.37616,{"lat":1178,"lon":1177},[1181],{"name":1182,"role":37,"phone":33,"phoneExt":33,"email":33},"Joseph Sacco, MD Principal Investigator",{"facility":1184,"status":62,"city":1185,"state":33,"zip":1186,"country":1174,"cosmosGeoPoint":1187,"geoPoint":1191,"contacts":1192},"University College Hospital","London","NW1 2BU",{"type":52,"coordinates":1188},[1189,1190],-0.12574,51.50853,{"lat":1190,"lon":1189},[1193],{"name":1194,"role":37,"phone":33,"phoneExt":33,"email":33},"Heather Shaw, MD Principal Investigator",{"facility":1196,"status":62,"city":1197,"state":33,"zip":1198,"country":1174,"cosmosGeoPoint":1199,"geoPoint":1203,"contacts":1204},"Weston Park Cancer Centre - PPDS","Sheffield","S10 2TF",{"type":52,"coordinates":1200},[1201,1202],-1.4659,53.38297,{"lat":1202,"lon":1201},[1205],{"name":1206,"role":37,"phone":33,"phoneExt":33,"email":33},"Krishnakumar Garadi, MD Principal Investigator",{"type":1208,"investigatorFullName":33,"investigatorTitle":33,"investigatorAffiliation":33,"oldNameTitle":33,"oldOrganization":33},"SPONSOR","100594111",false,"NCT07015190","Neoadjuvant Darovasertib in Primary Uveal Melanoma","A Randomized, Phase 3, Open-label Study of Neoadjuvant Darovasertib in Subjects With Primary Non-metastatic Uveal Melanoma (OptimUM-10)","Inclusion Criteria:\n\n* Primary non-metastatic uveal melanoma\n* Able and willing to provide written, informed consent before initiation of any study-related procedures, and in the opinion of the Investigator, to comply with all study requirements\n* ECOG 0 or 1\n* Adequate organ function\n\nExclusion Criteria:\n\n* Previous treatment for UM\n* Evidence of metastatic UM\n* Attributes that necessitate enucleation regardless of response to therapy\n* Evidence of progressive secondary underlying ocular disease that would confound longitudinal VA assessments\n* Presence of a malignant disease other than the one being treated in this study","ALL","18 Years",{"count":1218,"type":1219},520,"ESTIMATED","INTERVENTIONAL",[1222],"PHASE3","This is a Phase 3, randomized, multi-center, open-label study of neoadjuvant darovasertib in subjects with primary non-metastatic uveal melanoma (OptimUM-10)",[1225],"Uveal Melanoma",[1225,1227,1228,1229,23,27,1230,1231,1232,1233,1234,1235,1236,1237],"Plaque Brachytherapy","Enucleation","Neoadjuvant","Ocular Melanoma","Choroidal Melanoma","Ophthalmology","Ocular Oncology","Melanoma","Protein Kinase C","GNAQ","GNA11","2026-05-01",{"date":1240,"type":1241},"2026-05-06","ACTUAL",{"date":1243,"type":1241},"2026-01-25",{"date":1245,"type":1219},"2031-03",{"name":5,"class":6},94]